Patents by Inventor An Xiao

An Xiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12162901
    Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.
    Type: Grant
    Filed: September 30, 2021
    Date of Patent: December 10, 2024
    Assignee: The Regents of the University of California
    Inventors: Xi Chen, An Xiao, Anoopjit Kooner, Abhishek Santra, Ajit Varki, Hai Yu, Lee-Ping Wang, Wanqing Li
  • Patent number: 11918635
    Abstract: A method and a platform for detecting an immunogenicity of a tumor neoantigen are provided. Specifically, the detection method includes the following steps: culturing human peripheral blood monocytes ex vivo for 13 days, adding an antigenic peptide fragment of human influenza virus and stimulating and activating cytokines, antigenic peptides, and immunoadjuvants during the 13 days, and finally conducting enzyme-linked immunospot (ELISPOT) chromogenic reaction and instrument-based scanning, counting, and analysis to detect the immunogenicity of tumor neoantigen. An application of the detection method and platform in biomedicine is provided. Compared with the prior art, the detection method and platform have advantages and characteristics of a short detection period, high convenience, low consumption of experimental cells, and low detection cost. Therefore, the detection method and platform can be used for ex vivo high-throughput assay for the immunogenicity of the tumor neoantigen.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: March 5, 2024
    Assignees: NeoCura Bio-Medical Technology Co., Ltd, Beijing Neocurna Biotechnology corporation, Shenzhen Neocurna Biotechnology corporation
    Inventors: Youdong Pan, Qi Song, Ji Wan, Jun-Yuan Huang, An Xiao, Gang Liu, Ying Wen
  • Publication number: 20230419646
    Abstract: Embodiments of this disclosure relate to the field of artificial intelligence, and disclose a feature extraction method and apparatus. The method includes: obtaining a to-be-processed object, and obtaining a segmented object based on the to-be-processed object, where the segmented object includes some elements in the to-be-processed object, a first vector indicates the segmented object, and a second vector indicates some elements in the segmented object; performing feature extraction on the first vector to obtain a first feature, and performing feature extraction on the second vector to obtain a second feature; fusing at least two second features based on a first target weight, to obtain a first fused feature; and performing fusion processing on the first feature and the first fused feature to obtain a second fused feature, where the second fused feature is used to obtain a feature of the to-be-processed object.
    Type: Application
    Filed: August 25, 2023
    Publication date: December 28, 2023
    Inventors: Kai HAN, Yunhe WANG, An XIAO, Jianyuan GUO, Chunjing XU, Li QIAN
  • Publication number: 20230028237
    Abstract: A method for training an image processing model is provided. After an augmented image is obtained, a soft label of the augmented image is obtained, and the image processing model is trained based on guidance of the soft label, to improve performance of the image processing model. In addition, according to the method, the image processing model is trained based on guidance of a soft label, with a relatively high score, selected from soft labels of the augmented image, to further improve performance of the image processing model.
    Type: Application
    Filed: September 21, 2022
    Publication date: January 26, 2023
    Inventors: Longhui WEI, An XIAO, Lingxi XIE, Qi TIAN
  • Patent number: 11325936
    Abstract: New 2-deoxy-2,3-dehydro-sialic acids and 2,7-anhydro-sialic acids, which are useful as sialidase inhibitors, and enzymatic methods for preparing them are disclosed. The methods include forming a reaction mixture comprising a glycoside acceptor, a sialic acid donor, and a sialyltransferase; maintaining the reaction mixture under conditions sufficient to form a sialoside; and contacting the sialoside with a Streptococcus pneumoniae sialidase to form the sialic acid product. Methods for the inhibition and sialidases and the treatment of cancer and infectious diseases are also disclosed.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: May 10, 2022
    Assignee: The Regents of the University of California
    Inventors: Xi Chen, An Xiao, Wanqing Li, Xixuan Li, Yanhong Li, Teri Slack
  • Publication number: 20220106348
    Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.
    Type: Application
    Filed: September 30, 2021
    Publication date: April 7, 2022
    Inventors: Xi CHEN, An XIAO, Anoopjit KOONER, Abhishek SANTRA, Ajit VARKI, Hai YU, Lee-Ping WANG, Wanqing LI
  • Patent number: 11161868
    Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: November 2, 2021
    Assignee: The Regents of the University of California
    Inventors: Xi Chen, An Xiao, Anoopjit Kooner, Abhishek Santra, Ajit Varki, Hai Yu, Lee-Ping Wang, Wanqing Li
  • Publication number: 20210310010
    Abstract: A plasmid vector for expressing mRNA in vitro, a construction method and an application thereof are provided. The plasmid vector includes a poly(adenyl deoxyribonucleotide) (poly(dA)) fragment formed by more than 30 adenyl deoxyribonucleotides at the 3?-end tail of a gene to be inserted for expression. The plasmid vector for expressing mRNA in vitro in the present invention can express a target protein gene and a poly(A) formed by 60 adenyl ribonucleotides, and the expressed mRNA directly possesses the poly(A) without additional tailing operation. In addition, the mRNA transcribed in vitro shows stronger mRNA stability and higher protein expression ability after being transfected into cells.
    Type: Application
    Filed: September 3, 2020
    Publication date: October 7, 2021
    Applicant: Shenzhen NeoCura Biotechnology Corporation
    Inventors: Youdong PAN, Qi SONG, An XIAO, Yi WANG, Ji WAN, Gang LIU, Ying WEN
  • Publication number: 20210299058
    Abstract: A delivery system for mRNA nucleic acid drugs, a preparation method and an application thereof are provided. The delivery system includes lipid nanoparticles for loading one or more kinds of mRNA molecules, wherein the lipid nanoparticles are prepared from raw materials including an ionizable cationic lipid, a phospholipid auxiliary lipid, cholesterol, and a polyethylene glycol-derivatized phospholipid. In the mRNA nucleic acid drug targeted intracellular delivery system based on the non-viral carrier of the present invention, the mRNA is concentrated and loaded by the electrostatic interaction between the ionizable cationic lipid and the mRNA. Phospholipid auxiliary lipid component-mediated pH sensitivity and late endosomal escape enable mRNA nucleic acid drugs to be efficiently delivered to target cells and then released into the cytoplasm of the target cells for exerting a pharmacodynamic effect.
    Type: Application
    Filed: June 17, 2020
    Publication date: September 30, 2021
    Applicant: Shenzhen Neocura Biotechnology Corporation
    Inventors: Youdong PAN, Gang LIU, Yi WANG, An XIAO, Ji WAN, Ying WEN, Qi SONG
  • Publication number: 20210057043
    Abstract: A tumor neoantigen prediction platform and an application thereof in a neoantigen vaccine development system are provided. The present invention selects 55 HLA-A and HLA-B subtypes with a high proportion of Chinese population from a common database, then establishes a method for constructing cell lines expressing associated HLA subtypes, and subsequently analyzes the resulting HLA subtype cell line binding proteomes by protein mass spectrometry at an attomolar (10?18 molar) level; through very high-precision mass spectrometry of protein profiling presented on the surface of a single cell, the present invention builds a high-frequency HLA-binding polypeptide database for Chinese population; subsequently, a tumor neoantigen prediction algorithm is optimized by a prediction platform including the HLA-binding polypeptide database, thereby significantly improving the tumor neoantigen prediction accuracy.
    Type: Application
    Filed: June 18, 2020
    Publication date: February 25, 2021
    Applicant: Shenzhen Neocura Biotechnology Corporation
    Inventors: Youdong PAN, Qi SONG, Ji WAN, Jun-Yuan HUANG, An XIAO, Gang LIU, Ying WEN
  • Publication number: 20210055306
    Abstract: A method and a platform for detecting an immunogenicity of a tumor neoantigen are provided. Specifically, the detection method includes the following steps: culturing human peripheral blood monocytes ex vivo for 13 days, adding an antigenic peptide fragment of human influenza virus and stimulating and activating cytokines, antigenic peptides, and immunoadjuvants during the 13 days, and finally conducting enzyme-linked immunospot (ELISPOT) chromogenic reaction and instrument-based scanning, counting, and analysis to detect the immunogenicity of tumor neoantigen. An application of the detection method and platform in biomedicine is provided. Compared with the prior art, the detection method and platform have advantages and characteristics of a short detection period, high convenience, low consumption of experimental cells, and low detection cost. Therefore, the detection method and platform can be used for ex vivo high-throughput assay for the immunogenicity of the tumor neoantigen.
    Type: Application
    Filed: August 21, 2020
    Publication date: February 25, 2021
    Applicant: Shenzhen NeoCura Biotechnology Corporation
    Inventors: Youdong PAN, Qi SONG, Ji WAN, Jun-Yuan HUANG, An XIAO, Gang LIU, Ying WEN
  • Publication number: 20200190130
    Abstract: New 2-deoxy-2,3-dehydro-sialic acids and 2,7-anhydro-sialic acids, which are useful as sialidase inhibitors, and enzymatic methods for preparing them are disclosed. The methods include forming a reaction mixture comprising a glycoside acceptor, a sialic acid donor, and a sialyltransferase; maintaining the reaction mixture under conditions sufficient to form a sialoside; and contacting the sialoside with a Streptococcus pneumoniae sialidase to form the sialic acid product. Methods for the inhibition and sialidases and the treatment of cancer and infectious diseases are also disclosed.
    Type: Application
    Filed: April 27, 2018
    Publication date: June 18, 2020
    Inventors: Xi CHEN, An XIAO, Wanqing LI, Xixuan LI, Yanhong LI, Teri SLACK
  • Publication number: 20190367548
    Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.
    Type: Application
    Filed: May 21, 2019
    Publication date: December 5, 2019
    Inventors: Xi CHEN, An XIAO, Anoopjit KOONER, Abhishek SANTRA, Ajit VARKI, Hai YU, Lee-Ping WANG, Wanqing LI
  • Patent number: 9307665
    Abstract: The invention provides an air cavity package for a component. The package has a connection lead structure in which the or each connection lead has a connection zone within the package for receiving a wire connector. A region of no connection lead material is provided directly between the connection zone and the neighboring outer edge of the cavity. This provides a trap for flowing interconnect material.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: April 5, 2016
    Assignee: SAMBA HOLDCO NETHERLANDS B.V.
    Inventors: Michael Asis, Albertus Reijs, Tennyson Nguty, An Xiao
  • Publication number: 20140318854
    Abstract: The invention provides an air cavity package for a component. The package has a connection lead structure in which the or each connection lead has a connection zone within the package for receiving a wire connector. A region of no connection lead material is provided directly between the connection zone and the neighbouring outer edge of the cavity. This provides a trap for flowing interconnect material.
    Type: Application
    Filed: April 21, 2014
    Publication date: October 30, 2014
    Applicant: NXP B.V.
    Inventors: Michael Asis, Albertus Reijs, Tennyson Nguty, An Xiao
  • Patent number: D1039104
    Type: Grant
    Filed: June 16, 2023
    Date of Patent: August 13, 2024
    Inventor: Xin An Xiao