Patents by Inventor An Xiao
An Xiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 12162901Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.Type: GrantFiled: September 30, 2021Date of Patent: December 10, 2024Assignee: The Regents of the University of CaliforniaInventors: Xi Chen, An Xiao, Anoopjit Kooner, Abhishek Santra, Ajit Varki, Hai Yu, Lee-Ping Wang, Wanqing Li
-
Patent number: 11918635Abstract: A method and a platform for detecting an immunogenicity of a tumor neoantigen are provided. Specifically, the detection method includes the following steps: culturing human peripheral blood monocytes ex vivo for 13 days, adding an antigenic peptide fragment of human influenza virus and stimulating and activating cytokines, antigenic peptides, and immunoadjuvants during the 13 days, and finally conducting enzyme-linked immunospot (ELISPOT) chromogenic reaction and instrument-based scanning, counting, and analysis to detect the immunogenicity of tumor neoantigen. An application of the detection method and platform in biomedicine is provided. Compared with the prior art, the detection method and platform have advantages and characteristics of a short detection period, high convenience, low consumption of experimental cells, and low detection cost. Therefore, the detection method and platform can be used for ex vivo high-throughput assay for the immunogenicity of the tumor neoantigen.Type: GrantFiled: August 21, 2020Date of Patent: March 5, 2024Assignees: NeoCura Bio-Medical Technology Co., Ltd, Beijing Neocurna Biotechnology corporation, Shenzhen Neocurna Biotechnology corporationInventors: Youdong Pan, Qi Song, Ji Wan, Jun-Yuan Huang, An Xiao, Gang Liu, Ying Wen
-
Publication number: 20230419646Abstract: Embodiments of this disclosure relate to the field of artificial intelligence, and disclose a feature extraction method and apparatus. The method includes: obtaining a to-be-processed object, and obtaining a segmented object based on the to-be-processed object, where the segmented object includes some elements in the to-be-processed object, a first vector indicates the segmented object, and a second vector indicates some elements in the segmented object; performing feature extraction on the first vector to obtain a first feature, and performing feature extraction on the second vector to obtain a second feature; fusing at least two second features based on a first target weight, to obtain a first fused feature; and performing fusion processing on the first feature and the first fused feature to obtain a second fused feature, where the second fused feature is used to obtain a feature of the to-be-processed object.Type: ApplicationFiled: August 25, 2023Publication date: December 28, 2023Inventors: Kai HAN, Yunhe WANG, An XIAO, Jianyuan GUO, Chunjing XU, Li QIAN
-
Publication number: 20230028237Abstract: A method for training an image processing model is provided. After an augmented image is obtained, a soft label of the augmented image is obtained, and the image processing model is trained based on guidance of the soft label, to improve performance of the image processing model. In addition, according to the method, the image processing model is trained based on guidance of a soft label, with a relatively high score, selected from soft labels of the augmented image, to further improve performance of the image processing model.Type: ApplicationFiled: September 21, 2022Publication date: January 26, 2023Inventors: Longhui WEI, An XIAO, Lingxi XIE, Qi TIAN
-
Patent number: 11325936Abstract: New 2-deoxy-2,3-dehydro-sialic acids and 2,7-anhydro-sialic acids, which are useful as sialidase inhibitors, and enzymatic methods for preparing them are disclosed. The methods include forming a reaction mixture comprising a glycoside acceptor, a sialic acid donor, and a sialyltransferase; maintaining the reaction mixture under conditions sufficient to form a sialoside; and contacting the sialoside with a Streptococcus pneumoniae sialidase to form the sialic acid product. Methods for the inhibition and sialidases and the treatment of cancer and infectious diseases are also disclosed.Type: GrantFiled: April 27, 2018Date of Patent: May 10, 2022Assignee: The Regents of the University of CaliforniaInventors: Xi Chen, An Xiao, Wanqing Li, Xixuan Li, Yanhong Li, Teri Slack
-
Publication number: 20220106348Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.Type: ApplicationFiled: September 30, 2021Publication date: April 7, 2022Inventors: Xi CHEN, An XIAO, Anoopjit KOONER, Abhishek SANTRA, Ajit VARKI, Hai YU, Lee-Ping WANG, Wanqing LI
-
Patent number: 11161868Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.Type: GrantFiled: May 21, 2019Date of Patent: November 2, 2021Assignee: The Regents of the University of CaliforniaInventors: Xi Chen, An Xiao, Anoopjit Kooner, Abhishek Santra, Ajit Varki, Hai Yu, Lee-Ping Wang, Wanqing Li
-
Publication number: 20210310010Abstract: A plasmid vector for expressing mRNA in vitro, a construction method and an application thereof are provided. The plasmid vector includes a poly(adenyl deoxyribonucleotide) (poly(dA)) fragment formed by more than 30 adenyl deoxyribonucleotides at the 3?-end tail of a gene to be inserted for expression. The plasmid vector for expressing mRNA in vitro in the present invention can express a target protein gene and a poly(A) formed by 60 adenyl ribonucleotides, and the expressed mRNA directly possesses the poly(A) without additional tailing operation. In addition, the mRNA transcribed in vitro shows stronger mRNA stability and higher protein expression ability after being transfected into cells.Type: ApplicationFiled: September 3, 2020Publication date: October 7, 2021Applicant: Shenzhen NeoCura Biotechnology CorporationInventors: Youdong PAN, Qi SONG, An XIAO, Yi WANG, Ji WAN, Gang LIU, Ying WEN
-
Publication number: 20210299058Abstract: A delivery system for mRNA nucleic acid drugs, a preparation method and an application thereof are provided. The delivery system includes lipid nanoparticles for loading one or more kinds of mRNA molecules, wherein the lipid nanoparticles are prepared from raw materials including an ionizable cationic lipid, a phospholipid auxiliary lipid, cholesterol, and a polyethylene glycol-derivatized phospholipid. In the mRNA nucleic acid drug targeted intracellular delivery system based on the non-viral carrier of the present invention, the mRNA is concentrated and loaded by the electrostatic interaction between the ionizable cationic lipid and the mRNA. Phospholipid auxiliary lipid component-mediated pH sensitivity and late endosomal escape enable mRNA nucleic acid drugs to be efficiently delivered to target cells and then released into the cytoplasm of the target cells for exerting a pharmacodynamic effect.Type: ApplicationFiled: June 17, 2020Publication date: September 30, 2021Applicant: Shenzhen Neocura Biotechnology CorporationInventors: Youdong PAN, Gang LIU, Yi WANG, An XIAO, Ji WAN, Ying WEN, Qi SONG
-
Publication number: 20210057043Abstract: A tumor neoantigen prediction platform and an application thereof in a neoantigen vaccine development system are provided. The present invention selects 55 HLA-A and HLA-B subtypes with a high proportion of Chinese population from a common database, then establishes a method for constructing cell lines expressing associated HLA subtypes, and subsequently analyzes the resulting HLA subtype cell line binding proteomes by protein mass spectrometry at an attomolar (10?18 molar) level; through very high-precision mass spectrometry of protein profiling presented on the surface of a single cell, the present invention builds a high-frequency HLA-binding polypeptide database for Chinese population; subsequently, a tumor neoantigen prediction algorithm is optimized by a prediction platform including the HLA-binding polypeptide database, thereby significantly improving the tumor neoantigen prediction accuracy.Type: ApplicationFiled: June 18, 2020Publication date: February 25, 2021Applicant: Shenzhen Neocura Biotechnology CorporationInventors: Youdong PAN, Qi SONG, Ji WAN, Jun-Yuan HUANG, An XIAO, Gang LIU, Ying WEN
-
Publication number: 20210055306Abstract: A method and a platform for detecting an immunogenicity of a tumor neoantigen are provided. Specifically, the detection method includes the following steps: culturing human peripheral blood monocytes ex vivo for 13 days, adding an antigenic peptide fragment of human influenza virus and stimulating and activating cytokines, antigenic peptides, and immunoadjuvants during the 13 days, and finally conducting enzyme-linked immunospot (ELISPOT) chromogenic reaction and instrument-based scanning, counting, and analysis to detect the immunogenicity of tumor neoantigen. An application of the detection method and platform in biomedicine is provided. Compared with the prior art, the detection method and platform have advantages and characteristics of a short detection period, high convenience, low consumption of experimental cells, and low detection cost. Therefore, the detection method and platform can be used for ex vivo high-throughput assay for the immunogenicity of the tumor neoantigen.Type: ApplicationFiled: August 21, 2020Publication date: February 25, 2021Applicant: Shenzhen NeoCura Biotechnology CorporationInventors: Youdong PAN, Qi SONG, Ji WAN, Jun-Yuan HUANG, An XIAO, Gang LIU, Ying WEN
-
Publication number: 20200190130Abstract: New 2-deoxy-2,3-dehydro-sialic acids and 2,7-anhydro-sialic acids, which are useful as sialidase inhibitors, and enzymatic methods for preparing them are disclosed. The methods include forming a reaction mixture comprising a glycoside acceptor, a sialic acid donor, and a sialyltransferase; maintaining the reaction mixture under conditions sufficient to form a sialoside; and contacting the sialoside with a Streptococcus pneumoniae sialidase to form the sialic acid product. Methods for the inhibition and sialidases and the treatment of cancer and infectious diseases are also disclosed.Type: ApplicationFiled: April 27, 2018Publication date: June 18, 2020Inventors: Xi CHEN, An XIAO, Wanqing LI, Xixuan LI, Yanhong LI, Teri SLACK
-
Publication number: 20190367548Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.Type: ApplicationFiled: May 21, 2019Publication date: December 5, 2019Inventors: Xi CHEN, An XIAO, Anoopjit KOONER, Abhishek SANTRA, Ajit VARKI, Hai YU, Lee-Ping WANG, Wanqing LI
-
Patent number: 9307665Abstract: The invention provides an air cavity package for a component. The package has a connection lead structure in which the or each connection lead has a connection zone within the package for receiving a wire connector. A region of no connection lead material is provided directly between the connection zone and the neighboring outer edge of the cavity. This provides a trap for flowing interconnect material.Type: GrantFiled: April 21, 2014Date of Patent: April 5, 2016Assignee: SAMBA HOLDCO NETHERLANDS B.V.Inventors: Michael Asis, Albertus Reijs, Tennyson Nguty, An Xiao
-
Publication number: 20140318854Abstract: The invention provides an air cavity package for a component. The package has a connection lead structure in which the or each connection lead has a connection zone within the package for receiving a wire connector. A region of no connection lead material is provided directly between the connection zone and the neighbouring outer edge of the cavity. This provides a trap for flowing interconnect material.Type: ApplicationFiled: April 21, 2014Publication date: October 30, 2014Applicant: NXP B.V.Inventors: Michael Asis, Albertus Reijs, Tennyson Nguty, An Xiao
-
Patent number: D1039104Type: GrantFiled: June 16, 2023Date of Patent: August 13, 2024Inventor: Xin An Xiao