Abstract: The present invention relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human ?-klotho, and pharmaceutical compositions and methods of treatment comprising the same.

Abstract: The present disclosure provides a bispecific anti-CD3×CD20 polypeptide complex that contains a first antigen-binding moiety of the polypeptide complex and a second antigen-binding moiety, methods of producing the bispecific anti-CD3×CD20 polypeptide complex, methods of treating disease or disorder using the bispecific anti-CD3×CD20 polypeptide complex, polynucleotides encoding the bispecific anti-CD3×CD20 polypeptide complex, vectors and host cells containing said polynucleotides, and compositions and pharmaceutical compositions comprising the bispecific anti-CD3×CD20 polypeptide complex.

Abstract: The present invention provides a method of preparing a defatted animal dairy product enriched with microbial anaplerotic oil and animal dairy products rich in odd-chain fatty acids for consumption by human and non-human animals. Also provided are animal dairy products rich in odd-chain fatty acids (OCFA) for consumption by human and non-human animals, the animal dairy product comprising defatted raw animal milk and microbial anaplerotic oil rich in OCFA.

Abstract: A displaying base plate includes an opening region, an adjacent region surrounding the opening region, and a displaying region surrounding the adjacent region, and the displaying base plate located within the adjacent region includes: a substrate base plate; a flat layer and a passivation layer that are provided on one side of the substrate base plate, wherein the passivation layer is provided on one side of the flat layer that is further away from the substrate base plate, a surface of the one side of the flat layer that is further away from the substrate base plate includes at least an inclined plane adjacent to one side of the opening region, and the flat layer includes a first protrusion provided on the inclined plane; and a first isolating groove that at least partially overlaps with the first protrusion and extends throughout the passivation layer and extends into the first protrusion.

Abstract: Disclosed is an adjustable cryoablation needle, comprising a needle rod (3), a front-segment heat-insulated tube (1), a rear-segment heat-insulated tube (2), and an gas inlet structure (7) penetrating the needle rod (3) and the front-segment heat-insulated tube (1), wherein the needle rod (3) can move relative to the rear-segment heat-insulated tube (2) in the axial direction of the rear-segment heat-insulated tube (2) so as to adjust a first axial distance between the front end of the rear-segment heat-insulated tube (2) and the front end of the needle rod (3); and the front-segment heat-insulated tube (1) can move relative to the rear-segment heat-insulated tube (2) in the axial direction of the rear-segment heat-insulated tube (2) The adjustable cryoablation needle can prevent the inconvenience caused by a doctor selecting the model of the cryoablation needle.

Abstract: Provided in the present disclosure is an electronic device used for a network control terminal and a method used for the electronic device, and an electronic device used for a network node and a method used for the electronic device. The electronic device used for the network control terminal comprises: a processing circuit, configured to configure, for a relay link between the network node and one or more other network nodes, a SL-DRX for the network node and/or the one or more other network nodes and perform relay transmission between the network node and the one or more other network nodes on the basis of the configuration of the SL-DRX.

Abstract: Techniques for group control using service data objects (SDO) are disclosed. A device controller is configured to perform operations including: receiving, from device controllers that are configured to control devices so that the devices operate based on a shared set point, SDO messages using an SDO protocol; determining that the device controller is a master device controller for the device controllers, based at least on the SDO messages; and sending a setpoint update message including a modified value of the shared set point, using the SDO protocol, to slave device controllers in the device controllers, wherein a slave device controller in the slave device controllers is configured to adjust operation of at least one slave device in the devices, based at least on the setpoint update message.

Abstract: Behavior data associated with a user is obtained. The behavior data is generated when the user uses an Internet service and includes a user identification and identification information indicating the Internet service. At least one predefined carbon-saving quantity quantization algorithm is determined based on the identification information related to the Internet service. A carbon-saving quantity associated with the user is calculated based on the obtained behavior data and the determined at least one predefined carbon-saving quantity quantization algorithm. Based on the calculated carbon-saving quantity associated with the user and the user identification, user data is processed. The user data is related to the carbon-saving quantity associated with the user.

Abstract: Compounds of formula I, that induce RBM39 protein degradation, pharmaceutical compositions containing these compounds, and methods of using these compounds for treating diseases associated with RBM39 protein activity are described herein.

Abstract: Provided are a display panel, a drive method thereof and a display apparatus. The display panel includes a plurality of scan signal lines, a plurality of data signal lines and a plurality of sub-pixels; at least one sub-pixel includes switch assembly and a display unit, wherein the switch assembly at least includes a control terminal, an input terminal and an output terminal, wherein the input terminal is connected to the data signal line, the output terminal is connected to the display unit, and the control terminal or the input terminal is connected to the scan signal line; the display panel further includes at least one switch control line, which is connected to the control terminal of the switch assembly, and the switch control line is configured to control the input terminal and the output terminal of the switch assembly to be turned on or off.

Abstract: The present disclosure relates to a speech synthesis method and device, and a computer-readable storage medium, and relates to the field of computer technology. The method of the present disclosure includes: dividing a text into a plurality of segments according to a language category to which each of the segments belongs; converting each of the segments into a phoneme corresponding to the segment to generate a phoneme sequence of the text according to the language category to which each of the segments belongs; inputting the phoneme sequence into a speech synthesis model trained in advance and converting the phoneme sequence into a vocoder characteristic parameter; and inputting the vocoder characteristic parameter into a vocoder to generate a speech.

Abstract: The disclosure provides a driving backplate and a display device. The driving backplate includes a substrate having a plurality of light source regions where light sources are disposed, the plurality of light source regions being arranged in an array; and a plurality of control chips arranged in an array on the substrate, the plurality of control chips being in one-to-one correspondence with the plurality of light source regions and each configured to provide a driving signal to the light source in a corresponding light source region, wherein each column of control chips is divided into at least two groups, each group of control chips are coupled in series through a same signal line, and the at least two groups of control chips are coupled in parallel with each other.

Abstract: A key structure includes a keycap, a base plate, a first scissors-type connecting element, a second scissors-type connecting element and a reinforced connecting rod. The first and second scissors-type connecting elements are arranged between the keycap and the base plate. The first scissors-type connecting element includes a first inner frame and a first outer frame. The second scissors-type connecting element includes a second inner frame and a second outer frame. The keycap is movable upwardly or downwardly relative to the base plate along a specified path with the assistance of the first and second scissors-type connecting elements. The reinforced connecting rod includes a hollow rectangular main body. The first outer frame has a first extension structure. The second outer frame has a second extension structure. Moreover, two opposite sides of the hollow rectangular main body are respectively received within the first extension structure and the second extension structure.

Abstract: A CD73 inhibitor having the structure represented by formula (I), a preparation method therefor and an application thereof are provided. The series of compounds can be widely applied in the preparation of drugs for treating cancers or tumors that are at least partially mediated by CD73, autoimmune diseases and disorders and metabolic diseases, in particular drugs for treating melanoma, colon cancer, pancreatic cancer, breast cancer, prostate cancer, lung cancer, leukemia, brain tumor, lymphoma, ovarian cancer and Kaposi's sarcoma. A new generation of CD73 inhibitor drugs is expected to be developed.

Abstract: The disclosed computer-implemented method may include dynamically selecting transportation options to present to a transportation requestor device based on current transportation network conditions and transportation requestor device history. In some embodiments, transportation network may have many different ways of arranging a transportation requestor's trip, such as private rides, shared rides, immediate rides, and delayed rides. In some examples, the requestor's choice of transportation option may have an impact on the transportation network. In anticipation of or in response to a transportation request, the method may determine which transportation options will better benefit the transportation network and determine which transportation options to display to the requestor and/or the prominence with which the transportation products are displayed. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The present disclosure provides an electronic device and method for wireless communication, and a computer readable storage medium. The electronic device comprises a processing circuit, configured to: determine that a beam failure occurs in a downlink of an unlicensed frequency band and generate a beam failure recovery request; perform energy detection on a first channel of a selected candidate beam, so as to send the beam failure recovery request by means of the first channel when the energy detection indicates that the first channel is idle; start a first timer while enabling the energy detection; and in the case that the first timer expires but the energy detection does not indicate that the first channel is idle, reselect a candidate beam and perform energy detection on a first channel of the reselected candidate beam.

Abstract: Innovations in flexible reference picture management are described. For example, a video encoder and video decoder use a global reference picture set (“GRPS”) of reference pictures that remain in memory, and hence are available for use in video encoding/decoding, longer than conventional reference pictures. In particular, reference pictures of the GRPS remain available across random access boundaries. Or, as another example, a video encoder and video decoder clip a reference picture so that useful regions of the reference picture are retained in memory, while unhelpful or redundant regions of the reference picture are discarded. Reference picture clipping can reduce the amount of memory needed to store reference pictures or improve the utilization of available memory by providing better options for motion compensation. Or, as still another example, a video encoder and video decoder filter a reference picture to remove random noise (e.g., capture noise due to camera imperfections during capture).

Abstract: A method for extracting point cloud feature includes: obtaining an original point cloud, conducting hybrid scale voxelization on the original point cloud; generating point-wise hybrid scale voxel features by feature encoding the point cloud subjected to the hybrid scale voxelization; and generating pseudo image feature maps using aggregated features and projection scale information. In this way, problems that at a single voxel scale, the inference time is longer when the voxel scale is smaller, and the larger voxel fails to capture intricate features and accurate location of smaller objects can be effectively overcome.

Abstract: A set of workload criteria is determined from a workload associated with a plurality of sources. The workload is divided among a set of workload groups according to the set of workload criteria and a first workload scheduler. A set of edge computing resources is assigned to each workload group within the set according to the set of workload criteria and the set of workload groups. A portion of the workload associated with a subset of the plurality of sources is handled by a first subset of edge computing resources and a second workload scheduler, where the subset of sources is associated with a first workload group. The handling includes balancing, by the second workload scheduler, the portion of the workload among the subset of sources. The handled workload is reported to a control center.

Abstract: An inner guide rail switch (100) and a rail transit system (1000) having same. The inner guide rail switch (100) includes a fixed beam assembly (1) and a movable beam assembly (2). Four passageways are defined by the fixed beam assembly (1). The movable beam assembly (2) includes six movable beams. The four passageways are switched through combined movement of the six movable beams.