Abstract: Microorganisms are prolific producers of natural products, a group of molecules that make up the majority of drugs approved by the FDA in the past 35 years. After decades of mining, the low-hanging fruit has been picked and so discovery of drug-like molecules from microorganisms has come to a near-halt. The reason for this lack of productivity is that most biosynthetic pathways that give rise to natural products are not active under typical laboratory growth conditions. These so-called ‘cryptic’ or ‘silent’ pathways are a major source of new bioactive molecules and methods that reliably activate them could have a profound impact on drug discovery. Disclosed herein is a rapid genetics-free method for eliciting and detecting cryptic metabolites using an imaging mass spectrometry-based approach. An organism of choice is challenged with elicitors from a small molecule library. The molecules elicited are then imaged by mass spec, which allows for rapid identification of cryptic metabolites.

Abstract: Methods, devices, and systems for multi-carrier network operation are disclosed. In one embodiment, a method of performing channel scrambling in a multi-carrier network, wherein the multi-carrier network includes a first component carrier (“CC”) and a second CC between a base station and a user equipment (“UE”) comprises receiving a Cell Radio Network Temporary Identifier (“C-RNTI”) and a cell identification (“ID”) for at least one of the first CC and the second CC; and using the RNTI and the cell ID to perform scrambling of information transmitted on at least one of the first CC and the second CC.

Abstract: Techniques are disclosed for extracting micro-features at a pixel-level based on characteristics of one or more images. Importantly, the extraction is unsupervised, i.e., performed independent of any training data that defines particularly objects, allowing a behavior-recognition system to forgo a training phase and for object classification to proceed without being constrained by specify object definitions. A micro-feature extractor that does not require training data is adaptive and self-trains while performing the extraction. The extracted micro-features are represented as a micro-feature vector that may be input to a micro-classifier which groups object into object type clusters based on the micro-feature vectors.

Abstract: An approach is provided in which the approach loads an application page on a display that includes a set of reusable components. The approach collects a set of individual load times in response to loading the application page that indicate an amount of time that each one of the set of reusable components takes to render on the display. The approach matches the set of individual load times to the set of reusable components and provides the set of reusable components with the matched set of individual load times to a developer.

Abstract: The embodiments of the present disclosure disclose a computer-implemented method, a system, and a computer program product for distributing data on multiple servers to multiple nodes in a cluster. In the method, each of M servers is instructed to divide data thereon into N data segments. M and N are integers greater than one. The M servers are instructed to send N×M data segments on the M servers to N nodes in a cluster concurrently. For each of the M servers, the N data segments are sent respectively to the N nodes. When any given node in the cluster receives a data piece of a data segment from a server of the M servers, the given node is instructed to transmit the received data piece to remaining nodes in the cluster other than the given node.

Abstract: An electronic gaming machine includes a display device, a memory device, and a processor. The processor displays a matrix of symbol positions formed by a plurality of reels. The processor also displays a bingo card. The processor determines an outcome that includes a first plurality of symbols to display in the matrix of symbol positions and evaluates the outcome to determine a win amount. The processor populates the matrix of bingo positions with the first prize symbol to a bingo position of the matrix of bingo positions corresponding to a position of the prize symbol in the matrix of symbol positions. The processor evaluates the matrix of bingo positions to determine whether a predefined winning pattern is formed and, in response, determines an award value based at least in part on numerical values of prize symbols forming the predefined winning pattern in the matrix of bingo positions.

Abstract: Systems, apparatuses, and methods for realizing a peak-force scattering scanning near-field optical microscopy (PF-SNOM). Conventional scattering-type microscopy (s-SNOM) techniques uses tapping mode operation and lock-in detections that do not provide direct tomographic information with explicit tip-sample distance. Using a peak force scattering-type scanning near-field optical microscopy with a combination of peak force tapping mode and time-gated light detection, PF-SNOM enables direct sectioning of vertical near-field signals from a sample surface for both three-dimensional near-field imaging and spectroscopic analysis. PF-SNOM also delivers a spatial resolution of 5 nm and can simultaneously measure mechanical and electrical properties together with optical near-field signals.

Abstract: Disclosed herein are compounds of formula I. Compounds of formula I inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract: A cover assembly of a secondary battery. The cover assembly includes: a cover plate including a gas vent; a gas exhaust valve configured to seal the gas vent and deform in response to an increase in temperature to get out of a state of sealing the gas vent; and a sealing part arranged between the gas exhaust valve and the cover plate and surrounding the gas vent for sealing a gap between the gas exhaust valve and the cover plate.

Abstract: The present disclosure may be implemented in the form of a method or corresponding apparatus for sending signaling messages through an IPX proxy from a first network element. The at least one example embodiment includes a first network element located on a first mobile network, the first network element configured to establish an initial signaling connection with a second network element on a second mobile network. The first network element may be configured to send a signaling request message to the second network element, receive a signaling response message from the second network element, the received signaling response message including an indication of an IPX proxy selected by the second network element. The first network element may be further configured to establish a signaling connection with the IPX proxy indicated in the received signaling response message, and send a second signaling request message to the IPX proxy for mediation service.

Abstract: Provided are an oxazino-quinazoline and oxazino-quinoline type compound, a preparation method, and uses thereof. More particularly provided is a compound shown in formula (I), an isomer, a hydrate, a solvate, a pharmaceutically acceptable salt, a prodrug thereof, a preparation method, and uses thereof in preparing a drug acting as a kinase inhibitor.

Abstract: Providing access to an external application includes receiving login credentials to access a client instance, wherein the login credentials are associated with a user account, causing the client instance to provide a link to an external application in the client instance, detecting a request to navigate to the external application from the link, generating a authentication record for the user account and the external application, storing information for the user account based on the authentication record, and generating a URL for the external application based on the authentication record. Providing access to the external application also includes receiving, from a remote client device hosting the external application, an authorization request comprising nonce information, determining that the user account is authorized to access the external application based on the authentication table, and providing access to the external application.

Abstract: An electric vehicle includes in-vehicle multimedia set in a rotatable manner, and the rotatable in-vehicle multimedia is used for providing a charge operation interface and a discharge operation interface. The charge and discharge control method includes: receiving a wake-up instruction input by a user, where the wake-up instruction is generated by rotating the in-vehicle multimedia by the user, and the wake-up instruction includes a charge wake-up instruction and a discharge wake-up instruction; waking up the in-vehicle multimedia in a sleep mode according to the wake-up instruction, so that the in-vehicle multimedia correspondingly displays the charge operation interface or the discharge operation interface; receiving a setting instruction input by the user through an operation interface, where the setting instruction includes a charge setting instruction and a discharge setting instruction; and controlling the electric vehicle to execute the setting instruction.

Abstract: The present disclosure pertains to a system for providing client-side physiological condition estimations during a live video session. In some embodiments, the system includes a first client computer system that is caused to: (i) store a neural network on one or more computer-readable storage media of the first client computer system, (ii) obtain a live video stream of an individual via a camera of the first client computer system during a video streaming session between the first client computer system and a second client computer system, (iii) provide, during the video streaming session, video data of the live video stream as input to the neural network to obtain physiological condition information from the neural network, and (iv) provide, during the video streaming session, the physiological condition information for presentation at the second client computer system.

Abstract: The present disclosure provides a common voltage compensation circuit including a feedback signal input terminal and a compensation sub-circuit. The compensation sub-circuit is configured to generate a compensation voltage for compensating a common voltage according to a feedback signal from the feedback signal input terminal and a reference common voltage. The common voltage compensation circuit also includes a first filter sub-circuit, a first terminal of the first filter sub-circuit is electrically coupled to the feedback signal input terminal, and a second terminal of the first filter sub-circuit is electrically coupled to a first clock signal line. The feedback signal line arranged is adjacent to a second clock signal line, and a first clock signal in the first clock signal line and a second clock signal in the second clock signal line are inverted relative to each other. The present disclosure also provides a display driver and a display device.

Abstract: A method of fabricating a blazed diffraction grating comprises providing a master template substrate and imprinting periodically repeating lines on the master template substrate in a plurality of master template regions. The periodically repeating lines in different ones of the master template regions extend in different directions. The method additionally comprises using at least one of the master template regions as a master template to imprint at least one blazed diffraction grating pattern on a grating substrate.

Abstract: A single cantilever gas sensor includes a silicon substrate, a supporting film, a heating resistor, a isolation film, and a detecting electrode, which are successively stacked. The gas sensor is T-shaped and has a base structure and a cantilever structure The end portion of the cantilever structure is provided with a gas sensitive material. The present invention further provides a sensor array composed of the single cantilever gas sensors and a method for manufacturing the gas sensor. The method includes (1) selecting a silicon substrate; (2) preparing a supporting film; (3) preparing a heating resistor; (4) preparing an isolation film; (5) preparing a detecting electrode; (6) releasing a membrane; (7) loading a gas sensitive material.

Abstract: A method and a former for necking and thickening a tube end. The former includes a hydraulic cylinder, a pusher, a concave die, a filler block, a plurality of heating rods and a heating device. The hydraulic cylinder is connected to a disc provided with a guide sleeve. The pusher is provided on the hydraulic cylinder and passes through the guide sleeve. The concave die is provided at a side of the pusher and includes a mold cavity and a plurality of heating holes. The filler block is provided in the mold cavity. The heating rods are provided in the heating holes connected to the heating device. The filler block includes a tapered portion provided at one end of the filler block and a diameter-reduced portion. The tapered portion is threadedly connected to the diameter-reduced portion. An ejector pin is provided at one end of the diameter-reduced portion.

Abstract: The present disclosure provides a shift register unit, which comprises: a pull-down node control circuit, connected to a control node and a pull-down node, and configured to control a change in a potential of the pull-down node according to a potential of the control node, where the potential of the control node and the potential of the pull-down node are inversed in phase; and a first potential regulating circuit, connected to an upper-stage pull-up node and the control node, and configured to: transmit a potential of the upper-stage pull-up node to the control node when the potential of the upper-stage pull-up node is an effective operating potential; and disconnect a connection between the control node and the upper-stage pull-up node when the potential of the upper-stage pull-up node is not an effective operating potential.