Abstract: Provided are methods of subcutaneous administration of anti-CD38 monoclonal antibodies, such as daratumumab. Also provided are methods for the treatment of autoimmune diseases with subcutaneously administered anti-CD38 monoclonal antibodies. A corticosteroid is optionally administered prior to subcutaneous administration of the anti-CD38 antibody to prevent and/or reduce systemic injection related side effects.

Abstract: The present disclosure discloses a method for detecting disease probability which includes: collecting each datum associated with a user, and performing feature processing to each collected datum; constructing a multi-dimensional data set according to each datum after being feature processed; performing random sampling on the multi-dimensional data set to divide into a test set and a training set; building a model based on the training set to obtain a regression decision tree; testing the regression decision tree according to the test set, to calculate the disease probability of the user. The present disclosure further discloses a device, an apparatus for detecting disease probability, and a computer-readable storage medium.

Abstract: A method for video decoding at a decoder is provided. In the method, reconstructed samples of a reconstructed block of a picture are stored in a first reference sample memory. The first reference sample memory is configured to store at least one set of a number of luma samples and corresponding chroma samples of the reconstructed block. Further, reconstructed samples of a current block of the picture are stored in a second reference sample memory. The second reference sample memory is configured to store only one set of the number of luma samples and corresponding chroma samples of the current block. A current sub-block in the current block is reconstructed using an intra block copy (IBC) mode based on the stored reconstructed samples of a reference sub-block of the reconstructed block or the stored reconstructed samples of a reference sub-block of the current block.

Abstract: An elevator door system comprises a laterally installed door knife located on a car door hanging plate, door lock wheels located on a landing door hanging plate, a fixing plate disposed in a middle of the car door hanging plate. The fixing plate is connected to a transmission belt, so that door hanging plates can be driven to move. A position-limit plate is disposed above the door knife, and the door knife is controlled by the position-limit plate to clamp door lock wheels. At the same time, the door lock wheels are connected to and open a door hanger via a bar. In order to take advantage of the room saved by laterally moving of the door knife, an addition sill and a brush whose lengths are fit for the door opening area are disposed on a car door sill to fill the space when door is opened.

Abstract: The disclosure relates to a microtome having a cutting knife, an object holder mounted on a slide, the slide being movable relative to the cutting knife in a cutting direction and in a thickness defining direction, movement of the slide in the thickness defining direction being performed by a first electric motor controlled by a control unit, movement of the slide in the cutting direction being performed by a second electric motor controlled by the control unit, wherein the control unit is configured to control the movement of the slide in the thickness defining direction and in the cutting direction.

Abstract: A fibril-forming peptide having a structure of fN-[An1]-(Gly-X-Y)n-[Ac1]-L-[An2]-(Gly-X-Y)n-[Ac2]-L-fc where L is (Gly-Pro-Z)j and Z is Pro or Hyp. [An1], [An2], [Ac1] and [Ac2] are each chains of 0-3 amino acid residues. The peptide self-assembles to form a collagen-like material.

Abstract: An electrolysis device may include: a housing comprising a container having an open end, the container configured to contain a liquid when the container is oriented in an upright position; and an electrolysis circuit comprising: a power source; a plurality of electrodes disposed within the container and electrically coupled to the power source; an orientation switch electrically coupled to the power source, coupled to the housing, and oriented to switch when the container is oriented in the upright position; and a control circuit electrically coupled to the power source, the electrodes, and the orientation switch, wherein the electrolysis circuit is configured to operate when the electrodes pass an electric current above a predetermined current threshold and the container is oriented in the upright position.

Abstract: A method for controlling the quality of traditional Chinese patent medicines is based on metagenomics. The method includes extracting genomic DNA of a sample of the traditional Chinese patent medicine, constructing a library of the genomic DNA based on a high-throughput sequencing platform, and performing metagenomic sequencing. The data obtained from the metagenomic sequencing is processed to obtain the ITS2 sequence of the traditional Chinese patent medicine sample A BLAST alignment is performed on the ITS2 sequence in the DNA Barcoding System for Identifying Herbal Medicine, to obtain species identification results. The obtained identification results are compared with the labeled species of the traditional Chinese patent medicine to obtain a conclusion about the quality of the traditional Chinese patent medicine sample.

Abstract: The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification.

Abstract: Systems and methods are described for determining that the user interaction with a display of a computing device during display of a video comprising a sequence of frames indicates a region of interest in a current frame of the sequence of frames of the displayed video. For each frame of the sequence of frames after the current frame, the frame is cropped to generate a cropped frame comprising a portion of the frame including the region of interest in the frame, the cropped frame is enlarged based on a display size corresponding to an angle or orientation of the computing device during display of the video, and the enlarged cropped frame replaces the frame such that the enlarged cropped frame is displayed in the sequence of frames of the video on the display of the computing device instead of the frame.

Abstract: Provided are training method for descreening system, descreening method, device, apparatus and medium. The training method for descreening system comprises: obtaining a first error function based on a halftone position and a preset label value, obtaining a second error function based on simulation images and non-halftone training samples, obtaining a third error function and a fourth error function according to a discrimination result, obtaining a fifth error function according to feature A and feature B, and based on the characteristics of Generative Adversarial Networks, according to the second error function, third error function, fourth error function and fifth error function, the sixth error function and seventh error function are respectively obtained, then an error function is constructed according to the errors generated by training, and the network parameters of each part of the models in the descreening system are updated by backpropagation of error function.

Abstract: A schedule is stored indicating a frequency of replication from source to destination sites. When a replication job is initiated, information identifying one or more objects at the source site to be replicated is copied into a snapshot without pausing user operations against the one or more objects. The snapshot is compared with a previous snapshot to generate replication tasks for the replication job. The replication tasks are placed onto a message queue at the source site, where a worker node at the source site retrieves a replication task from the message queue and processes the replication task in conjunction with a worker node at the destination site.

Abstract: The present specification discloses a differential mechanism and a vehicle. The differential mechanism includes a shell. A left half axle gear, a right half axle gear, a planet wheel and a planet wheel axle are disposed in the shell. The planet wheel is rotatably mounted on the planet wheel axle and meshes with the left half axle gear and the right half axle gear. A power engagement device includes a first engagement portion and a second engagement portion. The first engagement portion is connected with the left half axle gear or the right half axle gear, and the second engagement portion rotates synchronously with and moves axially relative to the shell. An engagement portion drive device includes a drive pin and a drive portion. The drive portion is configured to drive the drive pin to drive the second engagement portion close to the first engagement portion along an axial direction.

Abstract: The present disclosure relates to methods for selectively hydrogenating acetylene, to methods for starting up a selective hydrogenation reactor, and to hydrogenation catalysts useful in such methods. In one aspect, the disclosure provides a variety of methods for starting up reactors for use in methods for selectively hydrogenating acetylene using a catalyst composition comprises a porous support, palladium, and one or more ionic liquids.

Abstract: Embodiments of the present disclosure provide an IP address configuration method and an IP address configuration device. The IP address configuration method includes: acquiring first data transmitted by a User Equipment (UE), wherein a source IP address of the first data is a default IP address or a random IP address; and determining an IP address allocated by a session management (SM) function entity to the UE as the source IP address of the first data and replacing the default IP address or the random IP address.

Abstract: The embodiments provide a channel location indication method and a related product, including that: a network-side device sends at least one piece of indication information, the at least one piece of indication information being configured to indicate a location offset between a data channel and a first control channel or between a second control channel and the first control channel, the location offset including a time-domain location offset and/or a frequency-domain location offset and the time-domain location offset being a symbol-level offset. The embodiments are favorable for improving flexibility and efficiency of channel resource allocation in a wireless communication system.

Abstract: Provided are methods, systems and apparatus for identifying agents with desired biological activity. Specifically, the methods, systems, and apparatus identify functional relationships between multiple agents and/or between one or more agents and a condition of interest. Data of multiple experimental batches are normalized, batch effects accounted for, and the adjusted data used to create a projection matrix or function. The projection matrix is used to project the data into a projection space, in which the distance between a query agent or a query condition and various candidate agents may be determined.

Abstract: Methods and an apparatus for communication between processes are provided. A first process obtains an original message to be sent, where the original message includes a message header and a message body. The first process determines the length of the message header and the length of the message body of the original message to be sent. The first process compresses the length of the message header according to the length of the message header and the length of the message body to obtain a compressed message. The first process adds the compressed message to a message queue pre-created for a second process, where the second process is configured to obtain the compressed message from the message queue.

Abstract: A shared resistor performs precharging and discharging functions of capacitors in an electric vehicle drive system. In a precharge state, the shared resistor is connected between the capacitors and a DC source via a precharge relay. In a discharge state, the resistor is connected across the capacitors via a discharge transistor. Otherwise, the resistor is disconnected. A bypass switch is connected between the resistor and an input capacitor. The bypass switch is rendered conductive during the precharge state and during the discharge state. The discharge transistor is activated only during the discharge state. As a result, the invention uses less components by virtue of eliminating separate resistance elements for pre-charging and discharging and by eliminating discharge switches dedicated to separate resistances. The circuit integration and the placement of components outside the inverter module improves overall system cost and packaging size.

Abstract: The present disclosure relates to methods for selectively hydrogenating acetylene, to methods for starting up a selective hydrogenation reactor, and to hydrogenation catalysts useful in such methods. In one aspect, the disclosure provides a method for selectively hydrogenating acetylene, the method comprising contacting a catalyst composition with a process gas. The catalyst composition comprises a porous support, palladium, and one or more ionic liquids. The process gas includes ethylene, present in the process gas in an amount of at least 20 mol. %; and acetylene, present in the process gas in an amount of at least 1 ppm. At least 90% of the acetylene present in the process gas is hydrogenated, and the selective hydrogenation is conducted without thermal runaway. Notably, the process gas is contacted with the catalyst at a gas hourly space velocity (GHSV) based on total catalyst volume in one bed or multiple beds of at least 7,100 h?1.