Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Abstract: Embodiments of this disclosure disclose a display panel and a display device including the display panel. The display panel includes: a base substrate, the base substrate including a display area and a non-display area around the display area; a touch electrode layer on the base substrate, the touch electrode layer being within the display area of the base substrate; and a plurality of signal lines electrically connected with the touch electrode layer, the plurality of signal lines being distributed within a first area of the non-display area. The display panel further includes at least one outer dummy trace within a second area of the non-display area, the second area is between the first area and an outer border of the non-display area, and the at least one outer dummy trace and the plurality of signal lines are separated from each other.

Abstract: The present technology provides a browser extension that can recognize downloadable objects on a webpage and provides functionality that makes it easier and more efficient to download the downloadable objects to a location in a content management system. For example the present technology can analyze a document object model of a webpage to find attributes indicating a URL is associated with a downloadable object.

Abstract: A method for detecting a borehole caving based on cuttings and elements logging data includes: integrating real-time elements logging data and real-time cuttings return data of a target well, and historical elements logging data and stratum evaluation data of an adjacent well; calculating a root mean square deviation (RMSD) ? of a relative content of each element of the target well and the adjacent well and a real-time cuttings return ratio; setting a threshold ? of the RMSD ? of the relative content of each element and a threshold range (a,b) of the real-time cuttings return ratio; and establishing an intelligent stratum identification model based on a support vector machine (SVM) for real-time determination of a horizon from which current cuttings are returned. The method can achieve effective borehole caving detection, such that on-site personnel can deal with borehole caving in time and prevent it from developing into a complicated drilling accident.

Abstract: Provided is an antibody or an antigen binding fragment thereof capable of specifically binding to Tumor necrosis factor receptor type 2, which comprises a VH, a VL or both, said VH comprises at least one HCDR, which comprises an amino acid sequence selected from the group consisting of the amino acid sequences as set forth in SEQ ID NO: 13, SEQ ID NO: 15 and SEQ ID NO: 17. The antibody or an antigen binding fragment thereof binds strongly and specifically to TNFR2.

Abstract: Embodiments of this disclosure disclose a display panel and a display device including the display panel. The display panel includes a base substrate, the base substrate including a display area and a non-display area around the display area, a touch electrode layer on the base substrate, the touch electrode layer being within the display area of the base substrate, and a plurality of signal lines electrically connected with the touch electrode layer, the plurality of signal lines being distributed within a first area of the non-display area adjacent to the display area. The display panel further includes a plurality of outer dummy traces within a second area of the non-display area, the second area is between the first area and an outer border of the non-display area, and the plurality of outer dummy traces and the plurality of signal lines are separated from each other.

Abstract: A magnetic digital microfluidic apparatus for manipulating a liquid droplet containing magnetic particles using a magnetic force, the apparatus comprising: a hydrophobic surface on which the liquid droplet containing magnetic particles can be moved using the magnetic force; and at least one surface energy trap provided to retain at least a portion of the liquid droplet thereon, the at least one surface energy trap comprising a layer of polydopamine. A method of magnetic digital microfluidic manipulation, the method comprising the steps of: a) contacting a liquid droplet on a hydrophobic surface with a polydopamine surface energy trap, the liquid droplet containing magnetic particles; b) retaining at least a portion of the liquid droplet on the surface energy trap; and c) moving at least the magnetic particles with a magnetic force.

Abstract: A method may include registering, with an offline job to be executed by a computer processor, an application programming interface (API) and an operation, obtaining, from a repository, a user consent of a user for the operation, and in response to obtaining the user consent, creating, for the user, an access token including the operation and the API. The user consent may be stored external to the access token. The method may further include transmitting the access token to the offline job, and calling, by the offline job, the API using the access token.

Abstract: Systems and methods for detecting worsening cardiac conditions such as worsening heart failure events are described. A system may include sensor circuits to sense physiological signals and signal processors to generate from the physiological signals first and second signal metrics. The system may include a risk stratifier circuit to produce a cardiac risk indication. The system may use at least the first signal metric to generate a primary detection indication, and use at least the second signal metric and the risk indication to generate a secondary detection indication. The risk indication may be used to modulate the second signal metric. A detector circuit may detect the worsening cardiac event using the primary and secondary detection indications.

Abstract: A display panel includes: a pixel driving circuit, a base substrate, a second conductive layer, a third conductive layer. The second conductive layer is disposed on a side of the base substrate, includes first signal lines, orthographic projections of the first signal lines extend in a first direction and spaced apart in a second direction, the first direction and the second direction intersect; the third conductive layer is disposed on a side of the second conductive layer away from the base substrate and includes second signal lines, orthographic projections of the second signal lines extend in the second direction and spaced apart in the first direction; the first signal lines and the second signal lines are configured to provide the same first signal to the pixel driving circuit, part of the first signal lines and the second signal lines are coupled through via holes.

Abstract: The present application discloses a display panel, a manufacturing method thereof, and a display device. The display panel includes a substrate; a gate layer; a gate insulating layer; an active layer; a source-drain layer including a source electrode and a drain electrode; a passivation layer provided with a contact hole; and a pixel electrode layer connected to the drain electrode through the contact hole; wherein a light-transmitting etch stop layer is disposed at a hole bottom of the contact hole, and the light-transmitting etch stop layer at least partially covers a hole bottom of the contact hole.

Abstract: A joint k-space and image-space reconstruction imaging method and a device, relating to the field of magnetic resonance imaging. The method comprises: first, using the k-space parallel imaging method to reconstruct under-sampled image frames having auto-calibration signals of a subject obtained from multi-frame imaging required for the measurement of magnetic resonance parameters; and then performing reconstruction in image space for other under-sampled image frame data without auto-calibration signals. In the method, an accurate sensitivity map required for the SENSE method is generated from under-sampled data, without the need of additional acquisition. By means of the present method, images that are almost identical to those obtained by the traditional GRAPPA method and without obvious artifacts can be obtained at a speed which is four times faster than that by the traditional GRAPPA method.

Abstract: A display module and a display device are disclosed. The display module includes a display panel and a back panel. The back panel includes a first sub-panel disposed on a backside of the display panel, and the first sub-panel includes a plurality of first regions spaced apart and a second region adjacent to the first regions, wherein a thickness of the first sub-panel in the first regions is greater than 0 and less than a thickness of the first sub-panel in the second region.

Abstract: A system and method for packet processing, the method being applied to a first network device and including sending a first packet to a second network device, where a control packet header of the first packet includes a first number, and the first number indicates a number of a packet that carries the first number and that is between the first network device and the second network device, and receiving a first acknowledgement packet from the second network device, where the first acknowledgement packet comprises an indication indicating whether the second network device receives the first packet.

Abstract: A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.

Abstract: Systems and methods for detecting worsening cardiac conditions such as worsening heart failure events are described. A system may include sensor circuits to sense physiological signals and signal processors to generate from the physiological signals first and second signal metrics. The system may include a risk stratifier circuit to produce a cardiac risk indication. The system may use at least the first signal metric to generate a primary detection indication, and use at least the second signal metric and the risk indication to generate a secondary detection indication. The risk indication may be used to modulate the second signal metric. A detector circuit may detect the worsening cardiac event using the primary and secondary detection indications.

Abstract: The present application relates to the field of mobile communications, and discloses a method and apparatus for determining a monitoring capability, a device, and a storage medium. The method comprises: determining a first monitoring capability and/or a second monitoring capability, wherein the first monitoring capability is a capability of a terminal device to monitor, on a first carrier, a physical downlink control channel (PDCCH) used for scheduling the first carrier, and the second monitoring capability is a capability of the terminal device to monitor, on a second carrier, the PDCCH used for scheduling the first carrier; or the first monitoring capability is a capability of the terminal device to monitor, on the first carrier and the second carrier, the PDCCH used for scheduling the first carrier; the first carrier and the second carrier are used for scheduling the first carrier; and the first carrier and the second carrier are different.

Abstract: A display substrate and a method for manufacturing the same, and a display device are provided. The display substrate includes a base substrate, a plurality of sub-pixels and an isolation structure. A light-emitting element of each sub-pixel includes a light emitting functional layer, and a first electrode and a second electrode which are located on two sides of the light emitting functional layer, the first electrode being located between the light emitting functional layer and the base substrate, and the light emitting functional layer including a conductive sub-layer. The isolation structure is located between adjacent sub-pixels, and the conductive sub-layer in the light emitting functional layer is disconnected at the position of the isolation structure. The isolation structure includes a plurality of ring-shaped isolation parts, each of which surrounds one sub-pixel.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.