Abstract: This disclosure describes methods, non-transitory computer-readable media, and systems that can (i) identify reads that align with at least some portion of alternative contiguous sequences representing structural variant haplotypes within a structural variant reference genome and (ii) generate a structural-variant-alignment tag within an alignment file for such read alignments to guide identifying candidate structural-variant locations. In addition to employing structural-variant-alignment tags, the disclosed systems identify read fragments that align or overlap with portions of alternate contiguous sequences representing an insertion (or other structural variant) and further masks such insertion-overlapping read fragments as part of an alignment file.

Abstract: Disclosed are a modified gel electrolyte separator, and a preparation method and use thereof, belonging to the technical field of novel battery separator materials. The modified gel electrolyte separator is prepared through impregnation in a modifying slurry including: in weight fraction, a nano functional material: 2% to 12%; a high polymer: 2% to 1%; a dispersant: 5% to 2%; a binder: 5% to 3%; and an organic solvent: 85% to 97%, wherein the nano functional material is silica; the high polymer is polyethylene oxide; the dispersant is a modified high block copolymer; the binder is an acrylic binder with N-methyl-2-pyrrolidone as a solvent; and the organic solvent is dichloromethane. The modified gel electrolyte separator shows high-temperature heat resistance, flame retardancy, and high ductility, as well as significantly improved mechanical and electrochemical properties, and exhibits broad application prospects in the preparation of lithium-ion batteries.

Abstract: Systems and methods are provided for vector-quantized image modeling using vision transformers and improved codebook handling. In particular, the present disclosure provides a Vector-quantized Image Modeling (VIM) approach that involves pre-training a machine learning model (e.g., Transformer model) to predict rasterized image tokens autoregressively. The discrete image tokens can be encoded from a learned Vision-Transformer-based VQGAN (example implementations of which can be referred to as ViT-VQGAN). The present disclosure proposes multiple improvements over vanilla VQGAN from architecture to codebook learning, yielding better efficiency and reconstruction fidelity. The improved ViT-VQGAN further improves vector-quantized image modeling tasks, including unconditional image generation, conditioned image generation (e.g., class-conditioned image generation), and unsupervised representation learning.

Abstract: Provided in the present invention is a compound serving as a KAT6 inhibitor. Specifically, provided in the present invention is a compound having a structure as represented by the following formula (I) and formula (XIV), or an optical isomer, a pharmaceutically acceptable salt, a prodrug, a deuterated derivative, a hydrate or a solvate thereof. The compound can be used for treating or preventing diseases or conditions associated with the activity or expression level of KAT6.

Abstract: The present disclosure relates to a method of manufacturing an engineered flooring product comprising a core layer. The method provides the steps of: (a) mixing a hydrate compound, one or more stabilizing agents, and water in a mixer, forming a raw material slurry; (b) spreading a first layer of the raw material slurry onto a cull plate; (c) curing the first layer of raw material slurry; (d) after step (c), releasing the cured first layer of raw material slurry from the cull plate; (e) after step (d), trimming the cured first layer of raw material slurry released from the cull plate; and, (f) after step (e), cooling the cured first layer of raw material slurry released from the cull plate for at least about 24 hours at a temperature ranging from about I0 C-30 C thereby forming the engineered flooring product.

Abstract: A display substrate includes a base substrate, touch electrodes, and signal lines. At least some of the signal lines are electrically connected to the touch electrodes. The signal line includes a first signal line and a second signal line adjacent to each other. The first signal line and the second signal line respectively comprise a first-layer wiring and/or a second-layer wiring overlapped with each other in a direction perpendicular to the base substrate and electrically connected to each other. A line width of the first signal line is greater than a line width of the second signal line. The first-layer wiring of at least one of the first signal line or the second signal line is disconnected, and the second-layer wiring of the first signal line is continuous in a disconnected position.

Abstract: A display panel includes a pixel drive circuit for driving a light emitting unit. The pixel drive circuit is connected to the first electrode of the light emitting unit, and the display panel further includes: a base substrate, a first power line, a second power line, and a common electrode layer. The first power line and the second power line are located a the display area of the display panel, the orthographic projection of the first power line on the base substrate is extended along the first direction, the orthographic projection of the second power line on the base substrate is extended along the second direction, and the second direction is intersected with the first direction, at least a part of the second power line is connected to at least a part of the first power line through a via hole.

Abstract: The invention provides a method for producing delamination-resistant embedded contact lenses involving use of a mold set in two-curing steps and a special lens-forming composition for forming a bulk hydrogel material for embedding a crosslinked polymeric insert. The mold set consists of three mold halves, one of which is used twice, the first time for molding an insert from an insert-forming composition and the second time for an embedded contact lens with the molded insert embedded therein from the special lens-forming composition that a vinylic crosslinking agent and or organic solvent both of which independent of each other can swell an insert by a moderate swelling degree. The resultant embedded hydrogel contact lenses can be free of deformation and delamination.

Abstract: The present invention provides a computer system and a method for processing a debug message of a computer system. The method includes the following steps: performing, by a first timer, timing when a computer system starts up; determining whether a first-stage confirmation signal is received within a first specific time; stopping the first timer and enabling a second timer to perform timing if the first-stage confirmation signal is received; determining whether a second-stage confirmation signal is received within a second specific time; stopping the second timer if the second-stage confirmation signal is received; enabling an input pin of a general-purpose input/output (GPIO) device to be at a low level if the first-stage confirmation signal is not received within the first specific time or the second-stage confirmation signal is not received within the second specific time; and outputting a debug message based on the low level.

Abstract: A microservice creation method comprises presenting a configuration interface to a user; receiving a business model that is of a microservice and that is configured by the user via the configuration interface, where the business model includes metadata of a plurality of business objects and metadata of a relation object that identifies a relation between the plurality of business objects; and generating code of the microservice based on the business model of the microservice. In the method, according to a domain-driven design concept, the code of the microservice is generated based on the user-defined business model, and specifically, based on the metadata of the business objects and the metadata of the relation object that identifies the business objects in the business model.

Abstract: A software test method and a software test system including a storage device and a processor are provided. A plurality of modules are stored. The processor executes the modules in the storage device. An interface module accesses activated use case information of an electronic device to generate a test case file, so that the electronic device performs a test call operation on the interface module according to the test case file through a component under test (CUT). The interface module includes simulation component interfaces. Executing the test call operation includes sub-test call operations. An execution module respectively analyzes the sub-test call operations performed by the CUT sequentially calling the simulation component interfaces to generate sets of test progress information. A determination module generates and provides a test result to the electronic device according to a test configuration file and the sets of test progress information to improve test performance.

Abstract: Provided are a monoclonal antibody binding to human CD38, an antigen-binding fragment thereof, a pharmaceutical composition comprising the same, and use thereof in the treatment of a CD38-positive cancer.

Abstract: A monitoring and evaluation method for comprehensive evaluation index of machine-harvested cotton defoliation effect and system thereof relates to the field of monitoring and evaluation of cotton-harvested indexes. The RGB images of the machine-harvested cotton canopy are firstly acquired to extract visible-light vegetation index features, color component features and texture features of machine-harvested cotton canopy RGB images; the visible-light vegetation index features, color component features and texture features are input to the trained comprehensive evaluation model of machine-harvested cotton defoliation effect, to output the defoliation effect evaluation value; finally, the harvesting timing of machine-harvested cotton is determined according to the defoliation effect evaluation value.

Abstract: A control method for a display device including a display panel and a backlight device is provided. The display panel includes multiple display zones. The backlight device includes multiple backlight zones. The backlight zones are sequentially illuminated. The illumination time when the first backlight zone is illuminated satisfies followings: t1?(m/n+a)×t2+t3, t1 is the time from the start of displaying each frame of an image to the illumination of the first backlight zone, m is the number of pixel rows, n is the number of the backlight zones, a is the number of pixel rows occupied by a portion of a light-emitting area that extends beyond the corresponding backlight zone when the backlight zone is illuminated, t2 is the scanning time for each pixel row of the display panel, and t3 is response time when the pixel row receives a row scanning signal.

Abstract: A display substrate includes a backplate, an anode layer, a first auxiliary layer, a second auxiliary layer, a third auxiliary layer, first light-emitting layers of at least two different colors between the first and second auxiliary layers, second light-emitting layers of at least two different colors between the second and third auxlliary layers, and a cathode layer. The first light-emitting layers at least include first blue light-emitting layers. The second light-emitting layers at least include second blue light-emitting layers. The first auxiliary layer includes film layers; and a portion, opposite to a first blue light-emitting layer, of the film layers has an optical thickness of L1.

Abstract: In various examples, a set of camera parameters associated with an input image are determined based on a disparity map and a signed defocus map. For example, a disparity model generates the disparity map indicating disparity values associated with pixels of the input image and a defocus model generates a signed defocus map indicating blur values associated with the pixels of the input image.

Abstract: Novel methods and systems for coordinating sound to both internal and external speakers for a device is disclosed. The audio signal is distributed among the internal and external speakers and aligned so that signals going to the internal speakers are aligned with signals going to the external speakers.

Abstract: Embodiments of the disclosure provides a method, an apparatus and a device for displaying a feed flow. The method includes: presenting a feed flow interface; displaying a video content corresponding to a first feed flow element in the feed flow in the feed flow interface, a type of the first feed flow element being a video type; in response to detecting a predetermined swipe operation input by a user in the feed flow interface, determining a second feed flow element to be displayed in the feed flow; in response to a type of the second feed flow element being an interactive type, loading an interactive material of an interactive content recommended by the second feed flow element into the Web View container; displaying an interaction process of the interactive content in the feed flow interface, the interaction process presenting a process of the interactive material changing with an interaction operation.

Abstract: The invention provides a method for producing embedded diffractive contact lenses involving use of a mold set in two-curing steps. The mold set consists of three mold halves, one of which is used twice, the first time for molding a diffractive insert and the second time for an embedded contact lens with the molded diffractive insert embedded therein. The twice-used mold half has been treated with a corona plasma or a vacuum UV in a central circular area having a diameter equal to or smaller than the diameter of the insert to ensure that the molded insert consistently adheres to the twice-used mold half, even though the other mating insert mold half for molding the diffractive insert has a great tendency to bind strongly the molded insert due to the diffractive structure on its molding surface.

Abstract: Systems and methods for providing a cross-lingual PDF analysis and translation system specifically designed for the energy industry. The cross-lingual PDF analysis and translation system uses various methods (e.g., tag-based or paragraph-based document extraction and mixing) to create a cross-lingual mixed document dataset by modifying HTML files from multilingual web pages. The cross-lingual mixed document dataset is used to retrain a LayoutXLM model, enabling the LayoutXLM model to further build cross-lingual relations by evaluating the model on various form understanding benchmarks.