Abstract: This present disclosure provides a kit and method for detecting at least one KANSARL fusion transcript from a biological sample from a subject. The kit comprises at least one of the following components: (a) at least one probe, wherein each of the at least one probe comprises a sequence that hybridizes specifically to a junction of the at least one KANSARL fusion transcript; (b) at least one pair of probes, wherein each of the at least one pair of probes comprises: a first probe comprising a sequence that hybridizes specifically to KANSL1; and a second probe comprising a sequence that hybridizes specifically to ARL17A; or (c) at least one pair of amplification primers, wherein each of the at least one pair of amplification primers are configured to specifically amplify the at least one KANSARL fusion transcript.

Abstract: The present disclosure describes pyridineamine compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

Abstract: The present disclosure provides a communication processing method, a communication processing apparatus, and a base station. The communication processing method is used for an SeNB which constitutes a dual-connection radio communication network with an MeNB, including: a first determination step of determining information about currently available service resources for distribution, in accordance with a resource condition, an admission control step of performing service admission processing on at least one first service in accordance with the information about the service resources, and a transmission step of transmitting service admission information indicating a service admission processing result to the MeNB so as to enable the MeNB to perform service processing in accordance with the service admission information.

Abstract: The present invention provides a stratigraphic correlation method and apparatus based on uncertainty. The stratigraphic correlation method comprises: determining a plurality of possible correlation positions in a well with uncertain layered position in a profile, in a stratigraphic correlation process; assigning a qualitative or quantitative certainty value to the plurality of correlation positions; and storing and displaying the plurality of correlation positions and certainty values thereof as different layered solutions on the profile, respectively. By setting a plurality of position solutions for a layer in the present invention, all possibilities of the layered position judged by the geological personnel can be recorded as references for the subsequent correlation of other profiles, the closing of the whole layered solution, and the quality control.

Abstract: A humidifier for humidification of air to be delivered to a patient's airways may include a humidification chamber, a reservoir and a water delivery mechanism. The humidification chamber may include a water retention feature such as a wick that encloses part of the flow path, a heating element for heating the humidification chamber, and an air flow baffle configured to promote humidification. The humidifier may be further configured to execute one or more algorithms, for example to determine a condition of the wick or to detect condensation in the flow path. In some forms, the humidifier may also comprise algorithms for controlling one or more components of the humidifier such as to control the build up of foreign matter on the wick.

Abstract: A thin-film deposition apparatus comprises a chamber; a carrier in the chamber; a showerhead on the carrier, wherein the showerhead comprises multiple first gas-dispensing holes, multiple second gas-dispensing holes and multiple plasma-generating portions; and a first gas inlet system for providing a first process gas, wherein the first process gas outputted from the multiple first gas-dispensing holes.

Abstract: Existing approaches to security within network, for instance oneM2M networks, are limited. For example, content might only be protected while the content is in transit between entities that trust each other. Here, the integrity and the confidentiality of content in an M2M network are protected. Such content may be “at rest,” such that the content is stored at a hosting node. Only authorized entities may store and retrieve the data that is stored at the hosting node, and the data may be protected from a confidentiality perspective and an integrity perspective.

Abstract: The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.

Abstract: A method and device for controlling a fermenting process, wherein the method comprises collecting samples of biological cells from a fermenting tank, obtaining the state information of the current biological cells based on the collected samples, comparing the state information of the current biological cells with preset target status information to obtain the difference between the state information of the current biological cells and preset target state information, and controlling the feed rate of nutritional solution into the fermenting tank. Real time control of biological fermenting process is thus accomplished based on the state information of the biological cells during fermentation, and the consistency during fermentation is improved. Complicated mathematical modeling and man-made data analysis are not required for the method and device.

Abstract: The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases.

Abstract: In an approach to tracking at least one target subject in a camera network, a search is started to find a target subject on a camera within a camera network. Features are extracted from the target subject and search queries are initiated in other nearby cameras within the camera network. Search queries attempt to detect target subjects and present the finds in a ranked order. Application of aggregate searches in multiple cameras and prior search results are used to improve matching results in the camera network; propagate a search of the target subject to discover the full pathway in the camera network; and project future occurrences of the target subject in subsequent cameras in the camera network.

Abstract: Methods for activating the surface of steel alloys to produce catalytic substrates for the synthesis of carbon nanomaterials by chemical vapor deposition are provided. Steel alloy substrates in a variety of forms are activated by brief (10 sec to 30 min) pre-treatment at high temperature (600-1000° C.) in an oxidizing environment (e.g., air) to activate the catalyst. Upon high temperature oxidative treatment, the initially smooth and protective chromium oxide coating layer of the steel alloy is destroyed, and the catalyst surface roughness progressively increases. Upon exposure of the pre-treated SS substrates to pyrolyzed hydrocarbon gases in nitrogen, carbon nanotubes are readily formed, and their diameters correlate with substrate surface roughness. Forests of vertically aligned nanotubes can be prepared with the method.

Abstract: A center-pillared full-face shaft drilling machine comprises a center pillar (1), device platforms (2), a derrick (3), a driving system (4), a personnel and material conveying system (5), a well wall support and protection system (6), a safeguard system (7), and an operation chamber (8). The derrick (3) is mounted at a wellhead. The operation chamber (8) is disposed on the derrick (3). The center pillar directly leads from the well bottom to the wellhead and is connected to a slide rack comprised in the derrick on the ground. The driving system (4) is mounted at the front end of the center pillar (1) of a device. The multiple device platforms (2) are sequentially mounted on the center pillar (1) of the device from rear to front. The personnel and material conveying system (5) and the safeguard system (7) are separately mounted on the device platforms at the rear of the driving system (4) and on the ground.

Abstract: A vertical shaft drilling rig using a novel drilling method, mainly comprising a derrick (1) and a mouth sealing flatcar (4) installed at the wellhead, and further comprising a drilling pipe (5), a pipe joint (6), a steady pressure device (7), a torque amplification driver (8), a cutter head (9), a muck removal system (10), a slurry treatment station (3), an electrical cabinet (14), a hydraulic station (13), and a power pipeline (11); a main drive (2) is mounted on the derrick; the lower part of the main drive is connected to the drilling pipe; the drilling pipe is provided with the pipe joint, the lower end of the drilling pipe is connected to the torque amplification driver; the lower end of the torque amplification driver is connected to the cutter head; the steady pressure device is mounted outside the torque amplification device; the slag dug up by the cutter head in the shaft is delivered to the slurry treatment station on the surface.

Abstract: Disclosed is a fingerprint identification sensor, which comprises: a sensor unit, comprising a capacitor array formed by a plurality of capacitor induction units and having an output, a power supply and a sensor ground output; a conversion circuit, connected to the device ground of the terminal device, and the output and the sensor ground of the sensor unit, and configured to, upon modulating the driving signal to the modulated signal, output the modulated signal to the sensor ground; an energy storage capacitor, connected between the power supply and the sensor ground, and configured to stabilize an operating voltage of the sensor unit; a high-speed transistor switch, connected to the power supply, and configured to perform synchronous switch-on and switch-off according to status of the conversion circuit power supply; and a power supply, connected to the conversion circuit and the power supply of the sensor unit via the high-speed transistor switch.

Abstract: A method for monitoring health of a server is disclosed. The method is performed by a cache device and includes: acquiring information related to results of health checkups on the server based on an inquiry from a load-balancing device about the results of health checkups on the server; and transmitting the information related to results of the health checkups on the server to the load-balancing device.

Abstract: A secondary encapsulation waterproof structure for hydroelectric power generator comprises: a magnet, sleeved on and around a rotation axis of a generator; a coil, disposed around the magnet; and a magnet encapsulation component, sleeved around the magnet. The magnet encapsulation component includes a column-shaped plastic sleeve, a column-shaped rubber sleeve, or a column-shaped ceramic sleeve, sleeved around the magnet. The secondary encapsulation waterproof structure for a hydroelectric power generator is simple in construction, and it utilizes the secondary encapsulation waterproof structure to overcome the insufficient waterproof capability of the prior art for a hydroelectric power generator obtained through barrel plating, to raise its waterproof and corrosion resistance capability, in achieving prolonged service life for the hydroelectric power generator.

Abstract: Microbial type rhodopsins, such as the light-gated cation-selective membrane channel, channelrhodopsin-2 (Chop2/ChR2) or the ion pump halorhodopsin (HaloR) are expressed in retinal ganglion cells upon transduction using recombinant AAV vectors. Selective targeting of these transgenes for expression in discrete subcellular regions or sites is achieved by including a sorting motif in the vector that can target either the central area or surround (off-center) area of these cells. Nucleic acid molecules comprising nucleotide sequences encoding such rhodopsins and sorting motifs and their use in methods of differential expression of the transgene are disclosed. These compositions and methods provide significant improvements for restoring visual perception and various aspects of vision, particular in patients with retinal disease.

Abstract: An apparatus for spatially correcting an image frame is disclosed. In some embodiments, the apparatus stores a frame of pixel values and scans a multi-pixel correction window across the frame. Spatial correction is performed on pixels within the window at correction positions during the scan. The spatial correction comprises estimating pixel values at value estimation positions based on one or more pixel values within the window for pixels satisfying a logical condition. The value estimation positions correspond to pixel values which do not fall within the window again during the scan. Further disclosed is an apparatus for detecting high-energy radiation, in which integration circuitry is used for integrating charge responsive to radiation photon interaction events. The circuits are controllable in accordance with an exposure control signal to vary an exposure window duration according to an operating parameter of the apparatus.

Abstract: A method and system of implementing continuous deployment of scripts in languages that only support single deployment. The method and system may develop incremental scripts based on differences between a pending script and an implemented script.