Abstract: Presented are systems, methods, and devices for provisioning sample support, controlled liquid deposition, and/or desired sample thicknesses during cryo-electron microscopy processes. A sample support for a cryo-electron microscopy process includes a support grid with multiple grid faces. The grid may be substantially rigid, flat and circular, may have a diameter of between about 2.9 and 3.1 mm, and may have a thickness of about 10 to 25 ?m. A foil covers at least one of the grid faces and includes multiple foil regions that each has a distinct thickness. The foil may be a thin and flexible metal or carbon foil. At least one of the foil regions contains an array of through-holes. A boundary between the foil regions with distinct thicknesses forms a step edge that pins thereto a receding contact line of a liquid drop deposited on the foil.

Abstract: A cooling device for a heat source, such as an electronic component, has a single or set of nano- and/or micro-sized channel(s) connected to a single or multiple reservoir(s). The heat source causes nucleation within a channel, and a vapor bubble forms removing heat from the heat source via evaporation of liquid to vapor in the bubble and condensation of the generated vapor at the cooler ends of the bubble. Thus, the channel operates as a passive heat pipe and removes heat from the source by passively circulating the cooling fluid between the vapor bubble and the reservoir(s).

Abstract: A cooling device for a heat source, such as an electronic component, has a single or set of nano- and/or micro-sized channel(s) connected to a single or multiple reservoir(s). The heat source causes nucleation within a channel, and a vapor bubble forms removing heat from the heat source via evaporation of liquid to vapor in the bubble and condensation of the generated vapor at the cooler ends of the bubble. Thus, the channel operates as a passive heat pipe and removes heat from the source by passively circulating the cooling fluid between the vapor bubble and the reservoir(s).