Abstract: Engineered bispecific antibodies with shifted interchain disulfide bond on one arm while maintaining the native interchain disulfide bond on the second arm are described. Also described are anti-CD47/FR? bispecific antibodies and antigen-binding fragments thereof. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases, such as cancer and/or associated complications.

Abstract: A current fed high-frequency isolated matrix converter and the corresponding modulation and control schemes are provided. The converter includes a current source full-bridge converter, a high-frequency transformer, a matrix converter, and a three-phase filter. An optimized space vector modulation solution is used for controlling the converter, and by comparing magnitudes of three-phase filter capacitor voltages to determine an action sequence of space vectors, switch tubes are turned on at zero voltage. A current source full-bridge circuit adopts a commutation strategy of a secondary clamping, and by calculating a leakage inductive current commutation time, full-bridge switch tubes are turned off at zero current to achieve safe and reliable commutation, and having advantages of a low system loss, a high efficiency, and a high power density.

Abstract: Sensor devices including dissolvable tissue-piercing tips are provided. Methods of using and fabricating sensor devices are also provided.

Abstract: A smart conference room system is provided. The smart conference room system includes an intelligent conference interactive panel including one or more processors configured to convert user input into a conference information, and a memory configured to store the conference information. The intelligent conference interactive panel is configured to transmit conference information to one or more terminal devices. The one or more terminal devices are configured to perform a controllable operation based on the conference information transmitted to the one or more terminal devices.

Abstract: This application provides a system, a method, an apparatus, and a computer-readable storage medium for warning. The system may include an image capture device deployed on a gaming site and configured to capture a live image of a game table on the gaming site; and a computing node deployed on the gaming site and being connected to the image capture device, wherein the computing node is configured to obtain, in response to a receipt of the live image sent by the image capture device, a detection result characterizing a gaming process by performing a detection on the live image; and report, in response to that the obtained detection result matches a first preset warning condition, first warning information corresponding to the first preset warning condition.

Abstract: Air filter media comprising at least one active bead layer comprises an antistatic agent and polyethylenimine coated polymeric beads that can provide better formaldehyde abatement properties than incumbent activated carbon filters and can be prepared by using existing processing facilities for manufacture of incumbent activated carbon filters.

Abstract: The present invention relates to a method of using a microfluidic chip comprising introducing a gas into the microfluidic chip to replace the liquid that has been introduced into the microfluidic chip and forming a micro-reaction chamber in the form of a liquid-in-gas in the microfluidic chip. The present invention also relates to a method for obtaining assay data, a computer program product embodied in a computer-readable medium and a kit. The methods described in the present invention are easy to operate, low cost, versatile, enabling rapid exchange of fluids, achieving efficient separation and capture of single particles with high purity. In addition, the methods can avoid clogging the chip and facilitate recycling.

Abstract: Embodiments of this application disclose a dielectric filter and a communication device. In one example, the dielectric filter includes: a first dielectric block and a second dielectric block that are stacked up, where a first surface of the first dielectric block is opposite to a second surface of the second dielectric block; a first blind hole, a first through hole, and two or more resonance through holes whose openings are located on the first surface of the first dielectric block, and a second through hole whose opening is located on the second surface of the second dielectric block. A metal layer on the first surface of the first dielectric block is connected to a metal layer on the second surface of the second dielectric block.

Abstract: There is described herein a method for capturing circulating tumor DNA (ctDNA) of interest from an animal sample, preferably a mammalian sample, further preferably a human patient sample, comprising cell-free DNA (cfDNA), the method comprising: adding to the patient sample a library of nucleic acid hybrid capture probes, wherein the library of 5 probes is complementary to both strands of the double stranded ctDNA of interest and the probes are tagged for capture; allowing the probes to hybridize to the ctDNA; and capturing the hybridized ctDNA using the tag on the probes. Libraries of probes for use with these methods are also described.

Abstract: Disclosed herein are methods for forming a buried layer using a low-temperature ion implant. In some embodiments a method may include providing an opening through a mask, wherein the mask is formed directly atop a substrate, and forming a buried layer in the substrate by performing a low-temperature ion implant through the opening of the mask. The method may further include forming an oxide layer over the substrate including over the buried layer.

Abstract: A method is disclosed—for a wireless communication device served by a network access node—of keeping a time reference at the wireless communication device. The wireless communication device is configured for operation according to at least first and second operational modes, the second operational mode having lower power consumption than the first operational mode. The method comprises (during operation according to the first operational mode) determining (for the second operational mode) desired timings of timing signals to be transmitted from the network access node, and transmitting a request signal to the network access node, wherein the request signal carries information of the desired timings of timing signals to be transmitted from the network access node. In some embodiments, the method further comprises receiving a response signal from the network access node, wherein the response signal carries information of actual timings of timing signals to be transmitted from the network access node.

Abstract: The present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, lung cancer (e.g., NSCLC), bladder cancer (e.g., UC), kidney cancer (e.g., RCC), breast cancer (e.g., TNBC), or melanoma. The invention provides methods of treating cancer (e.g., lung cancer (e.g., NSCLC), bladder cancer (e.g., UC), kidney cancer (e.g., RCC), breast cancer (e.g., TNBC), or melanoma), methods of determining whether a patient suffering from cancer (e.g., lung cancer (e.g., NSCLC), bladder cancer (e.g., UC), kidney cancer (e.g., RCC), breast cancer (e.g., TNBC), or melanoma) is likely to respond to treatment comprising a PD-L1 axis binding antagonist, methods of predicting responsiveness of a patient suffering from cancer (e.g., lung cancer (e.g., NSCLC), bladder cancer (e.g., UC), kidney cancer (e.g., RCC), breast cancer (e.g., TNBC), or melanoma) to treatment comprising a PD-L1 axis binding antagonist, and methods of selecting a therapy for a patient suffering from cancer (e.g.

Abstract: Disclosed herein are methods for backside wafer dopant activation using a low-temperature ion implant. In some embodiments, a method may include forming a semiconductor device atop a first main side of a substrate, and performing a low-temperature ion implant to a second main side of the substrate, wherein the first main side of the substrate is opposite the second main side of the substrate. The method may further include performing a second ion implant to the second main side of the substrate to form a collector layer.

Abstract: A resistive memory device includes a stacked structure and a copper via conductor structure. The stacked structure includes a first electrode, a second electrode, and a variable resistance layer. The second electrode is disposed above the first electrode in a vertical direction, and the variable resistance layer is disposed between the first electrode and the second electrode in the vertical direction. The copper via conductor structure is disposed under the stacked structure. The first electrode includes a tantalum nitride layer directly connected with the copper via conductor structure.

Abstract: The present invention discloses a tire changer including: a base; a wheel holder mounted on the base; and a tool bearing device that is arranged on the base and can drive a disassembly tool to move in the horizontal and vertical directions, and further including: a slider; a supporter; and a first driving device, wherein the supporter is fixed on the base; the tool bearing device is fixed on the slider; the first driving device is connected to the slider and the first driving device can drive the slider to slide along the vertical direction on the supporter. The tire changer has the advantages of small footprint, saving operating procedures, and improving work efficiency, etc.

Abstract: A spectroscopic assembly may include a spectrometer. The spectrometer may include an illumination source to generate a light to illuminate a sample. The spectrometer may include a sensor to obtain a spectroscopic measurement based on light, reflected by the sample, from the light illuminating the sample. The spectroscopic assembly may include a light pipe to transfer the light reflected from the sample. The light pipe may include a first opening to receive the spectrometer. The light pipe may include a second opening to receive the sample, such that the sample is enclosed by the light pipe and a base surface when the sample is received at the second opening. The light pipe may be associated with aligning the illumination source and the sensor with the sample.

Abstract: A gene-editing system includes an engineered photocleavable guide RNA to endow Cas9 nuclease and base editing activities with a built-in mechanism for fast, light-mediated deactivation. In methods of use, the system retains high editing efficiency, natively improves specificity, offers precise spatial and temporal control, improves base editing purity through early deactivation.

Abstract: A system and method for domain adaptation involves a first domain and a second domain. A machine learning system is trained with first sensor data and first label data of the first domain. Second sensor data of a second domain is obtained. Second label data is generated via the machine learning system based on the second sensor data. Inter-domain sensor data is generated by interpolating the first sensor data of the first domain with respect to the second sensor data of the second domain. Inter-domain label data is generated by interpolating first label data of the first domain with respect to second label data of the second domain. The machine learning system is operable to generate inter-domain output data in response to the inter-domain sensor data. Inter-domain loss data is generated based on the inter-domain output data with respect to the inter-domain label data. Parameters of the machine learning system are updated upon optimizing final loss data that includes at least the inter-domain loss data.