Patents by Inventor Ana Arminda Lopes Preto De Almeida

Ana Arminda Lopes Preto De Almeida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9393320
    Abstract: The present invention is the use of conjugated peptide sequences for inclusion in liposomal membranes. The combination can be done with folic acid or with an antibody of folic acid receptor coupled to N-terminal peptide. The presence of these peptides conjugated to liposomal formulations allows the targeting and subsequent release of therapeutic agents and/or imaging agents to cells expressing folic acid receptor. The developed method combines the ability of liposomes in the transport and release of drugs and the specific expression of folic acid receptor on the surface of cell membranes that allow transmembrane transport mediated by specific liposomes. Thus allows the transport of therapeutic agents and/or imaging agents, which are inside the liposome, either hydrophobic or hydrophilic. The therapeutic agents can be either pharmacological compounds (active agents) or siRNAs (small interference RNA) specific to defined target genes.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: July 19, 2016
    Assignee: UNIVERSIDADE DO MINHO
    Inventors: Artur Manuel Cavaco Paulo, Ana Arminda Lopes Preto de Almeida, Eugénia Sofia Da Costa Nogueira, Andreia Ferreira Castro Gomes
  • Publication number: 20140335164
    Abstract: The present invention is the use of conjugated peptide sequences for inclusion in liposomal membranes. The combination can be done with folic acid or with an antibody of folic acid receptor coupled to N-terminal peptide. The presence of these peptides conjugated to liposomal formulations allows the targeting and subsequent release of therapeutic agents and/or imaging agents to cells expressing folic acid receptor. The developed method combines the ability of liposomes in the transport and release of drugs and the specific expression of folic acid receptor on the surface of cell membranes that allow transmembrane transport mediated by specific liposomes. Thus allows the transport of therapeutic agents and/or imaging agents, which are inside the liposome, either hydrophobic or hydrophilic. The therapeutic agents can be either pharmacological compounds (active agents) or siRNAs (small interference RNA) specific to defined target genes.
    Type: Application
    Filed: December 7, 2012
    Publication date: November 13, 2014
    Applicant: Universidade do Minho
    Inventors: Artur Manuel Cavaco Paulo, Ana Arminda Lopes Preto De Almeida, Eugénia Sofia Da Costa Nogueira, Andreia Ferreira Castro Gomes