Patents by Inventor Ana Catarina Martins Grandela

Ana Catarina Martins Grandela has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vivo method for differentiating human pluripotent stem cells into atrial cardiomyocytes
    Patent number: 11773375
    Abstract: The present invention is in the field of pluripotent stem cells, more particularly cardiomyocytes derived from pluripotent stem cells. The present invention provides a novel method for differentiating human pluripotent stem cells into a population of cardiomyocytes having an atrial phenotype, and use of said atrial cardiomyocytes for screening of drugs, AF disease model, and others. The method of the invention is particularly useful to generate cardiomyocytes having a more developed or mature atrialphenotype and/or to generate higher yield of cardiomyocytes having an atrialphenotype.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: October 3, 2023
    Assignee: Ncardia B.V.
    Inventors: Stefan Robbert Braam, Ana Catarina Martins Grandela, Karin Langenberg
  • IN VITRO METHOD OF DIFFERENTIATING A HUMAN PLURIPOTENT STEM CELL POPULATION INTO A CARDIOMYOCYTE CELL POPULATION
    Publication number: 20220025333
    Abstract: The current invention relates to a method of differentiation of human pluripotent stem cells into a human stem-cell derived population of cardiomyocytes. The method comprises the use of specific combination of steps and compounds to induce and/or promote differentiation. The method also comprises steps directed to further maturation of the cardiomyocytes obtained with the method of the invention. Also provided are kits for use in a method of differentiation as well as cell populations obtainable with the method disclosed.
    Type: Application
    Filed: August 23, 2021
    Publication date: January 27, 2022
    Inventors: Stefan Robbert Braam, Ana Catarina Martins Grandela
  • In vitro method of differentiating a human pluripotent stem cell population into a cardiomyocyte cell population
    Patent number: 11136551
    Abstract: The current invention relates to a method of differentiation of human pluripotent stem cells into a human stem-cell derived population of cardiomyocytes. The method comprises the use of specific combination of steps and compounds to induce and/or promote differentiation. The method also comprises steps directed to further maturation of the cardiomyocytes obtained with the method of the invention. Also provided are kits for use in a method of differentiation as well as cell populations obtainable with the method disclosed.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: October 5, 2021
    Assignee: NCARDIA B.V.
    Inventors: Stefan Robbert Braam, Ana Catarina Martins Grandela
  • IN VIVO METHOD FOR DIFFERENTIATING HUMAN PLURIPOTENT STEM CELLS INTO ATRIAL CARDIOMYOCYTES
    Publication number: 20200216812
    Abstract: The present invention is in the field of pluripotent stem cells, more particularly cardiomyocytes derived from pluripotent stem cells. The present invention provides a novel method for differentiating human pluripotent stem cells into a population of cardiomyocytes having an atrial phenotype, and use of said atrial cardiomyocytes for screening of drugs, AF disease model, and others. The method of the invention is particularly useful to generate cardiomyocytes having a more developed or mature atrialphenotype and/or to generate higher yield of cardiomyocytes having an atrialphenotype.
    Type: Application
    Filed: March 27, 2017
    Publication date: July 9, 2020
    Inventors: Stefan Robbert Braam, Ana Catarina Martins Grandela, Karin Langenberg
  • AN IN VITRO METHOD OF DIFFERENTIATING A HUMAN PLURIPOTENT STEM CELL POPULATION INTO A CARDIOMYOCYTE CELL POPULATION
    Publication number: 20180251734
    Abstract: The current invention relates to a method of differentiation of human pluripotent stem cells into a human stem-cell derived population of cardiomyocytes. The method comprises the use of specific combination of steps and compounds to induce and/or promote differentiation. The method also comprises steps directed to further maturation of the cardiomyocytes obtained with the method of the invention. Also provided are kits for use in a method of differentiation as well as cell populations obtainable with the method disclosed.
    Type: Application
    Filed: August 31, 2016
    Publication date: September 6, 2018
    Applicant: Pluriomics B,V,
    Inventors: Stefan Robbert Braam, Ana Catarina Martins Grandela