Abstract: The present disclosure relates to the field of therapeutics for skin and mucosal infections and refers to the use of bromelain either alone or with antimicrobial agents to inhibit, to reduce or to treat biofilms in infections derived from the presence of this pathogenicity mechanism. This application aims to use the enzymatic action of bromelain to destroy the biofilms and allow for the penetration of the antifungals therefore improving their action in the site of infection, treating and reducing symptoms. The present disclosure may be used in the pharmaceutical field for the treatment of infections, as creams, lotions, gels or vials for local application in the skin or mucosa. Formulations with the ability to maintain the stability of the enzyme and of the other active components were developed with good characteristics for skin or mucosal application, particularly in the vagina, promoting, in this way, the efficacy and acceptability of the final product.

Abstract: The present solution refers to compositions for films or solid foams, and method of preparation thereof, for prevention and treatment of urogenital infections, particularly vaginal infections. A composition of aqueous base is described for a film/solid foam for use in the treatment of urogenital infections comprising: 0.4-25% (w/w) of a plasticizer, 0.4-20% (w/w) of at least a mucoadhesive polymer, At least a probiotic and/or prebiotic, At least an active substance in pharmacologically effective amounts. The compositions/films/solid foams described in the present disclosure can be used in the medical field and pharmaceutical industry, particularly for the local treatment of urogenital diseases, particularly vaginal infections.

Abstract: The present invention relates to dermatological stick compositions containing natural emollient waxes, oils and as active ingredient plants extract, and to uses thereof, in particular in the treatment dermatological disorders, such as lichen scleroses.