Patents by Inventor Ana GRICIUC

Ana GRICIUC has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11679095
    Abstract: Described herein are methods of treating neuron inflammation conditions, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, ischemic stroke, and prion disease, comprising administering a therapeutically effective amount of cromolyn or a cromolyn derivative compound.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: June 20, 2023
    Assignee: The General Hospital Corporation
    Inventors: David R. Elmaleh, Rudolph E. Tanzi, Timothy M. Shoup, Ana Griciuc
  • Publication number: 20230149345
    Abstract: The present disclosure relates to a method of treating one or more inflammation conditions induced by a coronavirus infection in a subject in need thereof, comprising administering a pharmaceutical composition comprising a compound of Formula I or Formula II, wherein R1 is halogen, OH, or —OC(O)C1-5alkyl, R2 and R3 are each independently selected from CO2R4 and CH2OR5; R4 is Li, Na, K, H, C1-5-alkyl, or —CH2CO(C1-5alkyl); and R5 is H or —C(O)(C1-5alkyl), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 5, 2021
    Publication date: May 18, 2023
    Inventors: David R. Elmaleh, Ana Griciuc, Ghazaleh Sadri-Vakili, Sabrina Paganoni, Rudolph E. Tanzi
  • Publication number: 20220218652
    Abstract: The present disclosure relates to a method of treating at least one Cell-Associated Neurotoxicity Syndrome (ICANS), cancer-related cognitive impairment, Infusion Reaction Syndrome (IRS), Capillary Leak Syndrome (CLS), Tumor Lysis Syndrome (TLS), Macrophage Activation Syndrome (MAS), Systemic Inflammatory Response Syndrome (SIRS), Immune Reconstitution Inflammatory Syndrome (IRIS), Graft-Versus-Host Disease (GVHD), Acute Respiratory Distress Syndrome (ARDS), sepsis, Ebola, avian influenza, smallpox, Systemic Inflammatory Response Syndrome (SIRS), and Immune-related Adverse Events Syndrome (IrAES) in a subject in need thereof, comprising administering a mast cell stabilizer or a compound of Formula I or Formula II: Formula I, Formula II, wherein R1 is halogen, OH, or —OC(O)C1-5alkyl R2 and R3 are each independently selected from CO2R4 or CH2OR5; R4 is i L, Na, K, H, C1-5alkyl, or —CH2CO(C1-5alkyl); and R5 is H or C(O)(C1-5alkyl), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 5, 2019
    Publication date: July 14, 2022
    Inventors: David R. Elmaleh, Rudolph E. Tanzi, Ana Griciuc, Robert Warren, Karen Reeves
  • Publication number: 20220079914
    Abstract: Described herein are methods of treating neuron inflammation conditions, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, ischemic stroke, and prion disease, comprising administering a therapeutically effective amount of cromolyn or a cromolyn derivative compound.
    Type: Application
    Filed: May 18, 2021
    Publication date: March 17, 2022
    Inventors: David R. Elmaleh, Rudolph E. Tanzi, Timothy M. Shoup, Ana Griciuc
  • Patent number: 11229651
    Abstract: The present invention relates to substances for the prophylaxis and treatment of a neurodegenerative disease which is not based on a protein-folding disorder. It further relates to substances for the stabilization of photoreceptors.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: January 25, 2022
    Assignee: Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet
    Inventors: Marius Ueffing, Blanca Arango-Gonzalez, Ana Griciuc
  • Patent number: 10888600
    Abstract: The present disclosure provides compositions and methods useful for treating or preventing diseases or disorders where beta amyloid accumulation or aggregation contributes to the pathology or symptomology of the disease, for example Alzheimer's disease.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: January 12, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Rudolph Emile Tanzi, Ana Griciuc
  • Publication number: 20180193415
    Abstract: The present disclosure provides compositions and methods useful for treating or preventing diseases or disorders where beta amyloid accumulation or aggregation contributes to the pathology or symptomology of the disease, for example Alzheimer's disease.
    Type: Application
    Filed: February 27, 2018
    Publication date: July 12, 2018
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Rudolph Emile TANZI, Ana GRICIUC
  • Patent number: 9937231
    Abstract: The present disclosure provides compositions and methods useful for treating or preventing diseases or disorders where beta amyloid accumulation or aggregation contributes to the pathology or symptomology of the disease, for example Alzheimer's disease.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: April 10, 2018
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Rudolph Emile Tanzi, Ana Griciuc
  • Publication number: 20160213671
    Abstract: The present invention relates to substances for the prophylaxis and treatment of a neurodegenerative disease which is not based on a protein-folding disorder. It further relates to substances for the stabilization of photoreceptors.
    Type: Application
    Filed: March 28, 2016
    Publication date: July 28, 2016
    Inventors: Marius Ueffing, Blanca Arango-Gonzalez, Ana Griciuc
  • Publication number: 20160038566
    Abstract: The present disclosure provides compositions and methods useful for treating or preventing diseases or disorders where beta amyloid accumulation or aggregation contributes to the pathology or symptomology of the disease, for example Alzheimer's disease.
    Type: Application
    Filed: March 27, 2014
    Publication date: February 11, 2016
    Inventors: Rudolph TANZI, Ana GRICIUC