Abstract: The present disclosure provides recombinant microorganisms and methods for the anaerobic production of 2,4-furandimethanol from one or more carbon sources. The microorganisms and methods provide redox-balanced and ATP positive pathways for co-producing 2,4-furandimethanol with ethanol and for co-producing 2,4-furandimethanol with ethanol and acetone and/or isopropanol. The method provides recombinant microorganisms that express endogenous and/or exogenous nucleic acid molecules encoding polypeptides that catalyze the conversion of a carbon source into 2,4-furandimethanol and that couple the 2,4-furandimethanol pathway with an additional metabolic pathway. The present disclosure further provides enzymatic production of 2,4-furandicarboxylic acid.

Abstract: The present disclosure provides recombinant microorganisms and methods for the anaerobic production of 2,4-furandimethanol from one or more carbon sources. The microorganisms and methods provide redox-balanced and ATP positive pathways for co-producing 2,4-furandimethanol with ethanol and for co-producing 2,4-furandimethanol with ethanol and acetone and/or isopropanol. The method provides recombinant microorganisms that express endogenous and/or exogenous nucleic acid molecules encoding polypeptides that catalyze the conversion of a carbon source into 2,4-furandimethanol and that couple the 2,4-furandimethanol pathway with an additional metabolic pathway. The present disclosure further provides enzymatic production of 2,4-furandicarboxylic acid.

Abstract: The present disclosure relates to single and/or multi-stage, biological processes and systems for converting C5, C6, and/or disaccharide carbon sources to desirable products including monoethylene glycol (MEG) and one or more three-carbon compounds such as acetone, isopropanol or propene. The MEG and one or more three-carbon compounds described herein are useful as starting material for production of other compounds or as end products for industrial and household use. The disclosure further relates to the processes carrying out fermentations of substrates in a single phase bioreactor or in a multiphase bioreactor comprising growth and production phases. Additionally, the processes and systems described herein result in high productivity and yield of the desired products due to intermittent or continuous removal of products to avoid inhibitory effects.

Abstract: The present disclosure relates to single and/or multi-stage, biological processes and systems for converting C5, C6, and/or disaccharide carbon sources to desirable products including monoethylene glycol (MEG) and one or more three-carbon compounds such as acetone, isopropanol or propene. The MEG and one or more three-carbon compounds described herein are useful as starting material for production of other compounds or as end products for industrial and household use. The disclosure further relates to the processes carrying out fermentations of substrates in a single phase bioreactor or in a multiphase bioreactor comprising growth and production phases. Additionally, the processes and systems described herein result in high productivity and yield of the desired products due to intermittent or continuous removal of products to avoid inhibitory effects.