Patents by Inventor Ana Leticia MARAGNO

Ana Leticia MARAGNO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
    Publication number: 20240042051
    Abstract: Anti-CD48 antibody-drug conjugates are disclosed. The anti-CD48 antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety and an anti-CD48 antibody or antigen-binding fragment thereof that binds an antigen target, e.g., an antigen expressed on a tumor or other cancer cell. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.
    Type: Application
    Filed: November 23, 2021
    Publication date: February 8, 2024
    Inventors: Matthew T. Burger, Zhuoliang Chen, Joseph Anthony D'Alessio, Claudia Judith Klinter, Eric McNeill, Cornelia Anne Mundt, Katsumasa Nakajima, Richard Vaughan Newcombe, Mark G. Palermo, Tamas Schweighoffer, Bing Yu, Katharina Winkelbach, Qiang Zhang, Laura Bresson, Frédéric Colland, Ana Leticia Maragno, Francesca Rocchetti
  • MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
    Publication number: 20230092679
    Abstract: Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.
    Type: Application
    Filed: May 19, 2020
    Publication date: March 23, 2023
    Inventors: Matthew T. Burger, Maia Chanrion, Frédéric Colland, Marton Csekei, Lea Delacour, Patrice Desos, Olivier Geneste, Jean-Michel Henlin, Vesela Kostova, Andras Kotschy, Ana Leticia Maragno, Eric McNeill, Mark G. Palermo, Francesca Rocchetti, Jérôme Starck, Bing Yu, Qiang Zhang, Ágnes Proszenyák, Szabolcs Sipos, Zhuoliang Chen, Katsumasa Nakajima, Joseph Anthony D'Alessio
  • MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
    Publication number: 20230081720
    Abstract: Anti-CD74 antibody-drug conjugates are disclosed. The anti-CD74 antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety and an anti-CD74 antibody or antigen-binding fragment thereof that binds an antigen target, e.g., an antigen expressed on a tumor or other cancer cell. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.
    Type: Application
    Filed: May 19, 2020
    Publication date: March 16, 2023
    Inventors: Matthew T. Burger, Maia Chanrion, Frédéric Colland, Marton Csekei, Lea Delacour, Patrice Desos, Olivier Geneste, Jean-Michel Henlin, Vesela Kostova, Andras Kotschy, Ana Leticia Maragno, Eric McNeill, Mark G. Palermo, Francesca Rocchetti, Jérôme Starck, Bing Yu, Qiang Zhang, Ágnes Proszenyák, Szabolcs Sipos, Zhuoliang Chen, Katsumasa Nakajima, Joseph Anthony D'Alessio, John William Blankenship
  • 6,7-DIHYDRO-5H-PYRIDO[2,3-C]PYRIDAZINE DERIVATIVES AND RELATED COMPOUNDS AS BCL-XL PROTEIN INHIBITORS AND PRO-APOPTOTIC AGENTS FOR TREATING CANCER
    Publication number: 20220363677
    Abstract: Compounds of formula (I): wherein Het, Het1, Het2, A4, A5, Z1, R1, R2 and R3 are as defined in the description. Medicaments.
    Type: Application
    Filed: July 28, 2020
    Publication date: November 17, 2022
    Inventors: Tibor NOVÁK, James Edward Paul DAVIDSON, Attila PACZAL, Jérôme-Benoît STARCK, András KOTSCHY, James Brooke MURRAY, Simon BEDFORD, Maïa CHANRION, Frédéric COLLAND, Mark Philip DODSWORTH, Andràs HERNER, Ana Leticia MARAGNO, Emma SANDERS, Mátyás Pál TIMÁRI, Paul WEBB
  • Combination of a Mcl-1 inhibitor and a standard of care treatment for hematologic cancers, uses and pharmaceutical compositions thereof
    Patent number: 11466023
    Abstract: A combination comprising a Mcl-1 inhibitor and a second anticancer agent, wherein the second anticancer agent is selected from anthracyclines, cytarabine and hypomethylating agents, and compositions and uses thereof.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: October 11, 2022
    Assignees: LES LABORATOIRES SERVIER, NOVARTIS AG
    Inventors: Andrew Wei, Donia Moujalled, Giovanna Pomilio, Olivier Geneste, Ana Leticia Maragno
  • 3,6-DIAMINO-PYRIDAZIN-3-YL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS
    Publication number: 20220289734
    Abstract: Compounds of formula (I): wherein Het1, Het2, R1, R2 and R3 are as defined in the description.
    Type: Application
    Filed: July 28, 2020
    Publication date: September 15, 2022
    Inventors: James Edward Paul DAVIDSON, Tibor NOVÁK, Attila PACZAL, András KOTSCHY, Jérôme-Benoît STARCK, James Brooke MURRAY, Simon BEDFORD, Maïa CHANRION, Frédéric COLLAND, Patrice DESOS, Mark Philip DODSWORTH, Petra DUNKEL, Andràs HERNER, Zoltán MADARÁSZ, Ana Leticia MARAGNO, Márk MOLNÁR, Miklós NYERGES, Rachel Jane PARSONS, Monika RUDASOVÁ, Ágnes STROFEK, Marianna SZIGETI, Mátyás Pál TIMÁRI, Paul WEBB
  • COMBINATION OF A MCL-1 INHIBITOR AND A STANDARD OF CARE TREATMENT FOR HEMATOLOGIC CANCERS, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20200392151
    Abstract: A combination comprising a Mcl-1 inhibitor and a second anticancer agent, wherein the second anticancer agent is selected from anthracyclines, cytarabine and hypomethylating agents, and compositions and uses thereof.
    Type: Application
    Filed: June 21, 2018
    Publication date: December 17, 2020
    Inventors: Andrew WEI, Donia MOUJALLED, Giovanna POMILIO, Olivier GENESTE, Ana Leticia MARAGNO
  • Combination of a MCL-1 inhibitor and a taxane compound, uses and pharmaceutical compositions thereof
    Patent number: 10765680
    Abstract: A combination comprising a MCL-1 inhibitor and a taxane compound, and compositions and uses thereof.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: September 8, 2020
    Assignees: LES LABORATORIES SERVIER, NOVARTIS AG
    Inventors: Dale Porter, Ensar Halilovic, Maïa Chanrion, Ana Leticia Maragno, Olivier Geneste, Delphine Merino, James Whittle, François Vaillant, Jane Visvader, Geoffrey Lindeman, Guillaume Lessene, Elisabetta Marangoni
  • COMBINATION OF A MCL-1 INHIBITOR AND A TAXANE COMPOUND, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20190336505
    Abstract: A combination comprising a MCL-1 inhibitor and a taxane compound, and compositions and uses thereof.
    Type: Application
    Filed: January 5, 2018
    Publication date: November 7, 2019
    Inventors: Dale PORTER, Ensar HALILOVIC, Maïa CHANRION, Ana Leticia MARAGNO, Olivier GENESTE, Delphine MERINO, James WHITTLE, François VAILLANT, Jane VISVADER, Geoffrey LINDEMAN, Guillaume LESSENE, Elisabetta MARANGONI
  • Ammonium derivatives, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10457689
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6 and Y are as defined in the description. Medicaments.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: October 29, 2019
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Attila Paczal, Zoltán Szlávik, András Kotschy, Maïa Chanrion, Ana Leticia Maragno, Olivier Geneste, Didier Demarles, Balázs Bálint, Szabolcs Sipos
  • COMBINATION OF A BCL-2 INHIBITOR AND A MCL-1 INHIBITOR, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20190240225
    Abstract: A combination comprising a BCL-2 inhibitor and a MCL1 inhibitor, and compositions and uses thereof.
    Type: Application
    Filed: July 21, 2017
    Publication date: August 8, 2019
    Applicants: LES LABORATOIRES SERVIER, NOVARTIS AG
    Inventors: Andrew WEI, Donia MOUJALLED, Giovanna POMILIO, Ana Leticia MARAGNO, Olivier GENESTE, Audrey CLAPERON, Heiko MAACKE, Ensar HALILOVIC, Dale PORTER, Erick MORRIS, Youzhen WANG, Sneha SANGHAVI, Prakash MISTRY
  • AMMONIUM DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20190031677
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6 and Y are as defined in the description. Medicaments.
    Type: Application
    Filed: December 19, 2016
    Publication date: January 31, 2019
    Inventors: Attila PACZAL, Zoltán SZLÁVIK, András KOTSCHY, Maïa CHANRION, Ana Leticia MARAGNO, Olivier GENESTE, Didier DEMARLES, Balázs BÁLINT, Szabolcs SIPOS