Patents by Inventor ANA MARIA CUERVO

ANA MARIA CUERVO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of Chaperone-Mediated Autophagy Activators For Treating Or Preventing Blood Cancers And Myelodysplastic Syndromes And Enriching Hematopoietic Stem Cell Populations
    Publication number: 20240156872
    Abstract: The present disclosure provides methods of treating disease and disorders of the hematological system. The disclosure provides a method of expanding a population of hematopoietic stem cells (HSCs) while maintaining the population in an undifferentiated state comprising contacting the population of HSCs in the presence of a CMA activator for a period of time until a sufficient number of HSCs is obtained thereby producing an expanded HSC population.
    Type: Application
    Filed: July 13, 2023
    Publication date: May 16, 2024
    Inventors: Ana Maria CUERVO, Evripidis GAVATHIOTIS
  • Compounds useful as chaperone-mediated autophagy modulators
    Patent number: 11834424
    Abstract: Compounds and pharmaceutically acceptable salts thereof of Formula I are disclosed. Certain compounds and salts of Formula I are active as CMA modulators. The disclosure provides pharmaceutical compositions containing a compound of Formula I.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: December 5, 2023
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
    Inventors: Ana Maria Cuervo, Evripidis Gavathiotis
  • Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof
    Patent number: 11591324
    Abstract: Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RAR?) in subjects in need thereof.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: February 28, 2023
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
    Inventors: Ana Maria Cuervo, Evripidis Gavathiotis, Qisheng Xin, Bhaskar C. Das
  • BENZOXAZOLE AND RELATED COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS
    Publication number: 20210387953
    Abstract: Compounds and pharmaceutically acceptable salts thereof of Formula I are disclosed. The variables, e.g. R1-R9, X, and Y are defined herein. Certain compounds and salts of Formula I are active as CMA modulators. The disclosure provides pharmaceutical compositions containing a compound of Formula I and methods of treating disorders responsive to CMA modulation.
    Type: Application
    Filed: October 10, 2019
    Publication date: December 16, 2021
    Inventors: Ana Maria Cuervo, Evripidis Gavathiotis
  • COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS
    Publication number: 20210317095
    Abstract: Compounds and pharmaceutically acceptable salts thereof of Formula I are disclosed. Certain compounds and salts of Formula I are active as CMA modulators. The disclosure provides pharmaceutical compositions containing a compound of Formula I.
    Type: Application
    Filed: August 30, 2018
    Publication date: October 14, 2021
    Inventors: Ana Maria CUERVO, Evripidis GAVATHIOTIS
  • RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF
    Publication number: 20210053958
    Abstract: Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RAR?) in subjects in need thereof.
    Type: Application
    Filed: August 4, 2020
    Publication date: February 25, 2021
    Inventors: Ana Maria CUERVO, Evripidis GAVATHIOTIS, Qisheng XIN, Bhaskar C. DAS
  • Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof
    Patent number: 10766886
    Abstract: Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RAR?) in subjects in need thereof.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: September 8, 2020
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
    Inventors: Ana Maria Cuervo, Evripidis Gavathiotis, Qisheng Xin, Bhaskar C. Das
  • RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF
    Publication number: 20190225599
    Abstract: Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RAR?) in subjects in need thereof.
    Type: Application
    Filed: December 5, 2018
    Publication date: July 25, 2019
    Inventors: Ana Maria CUERVO, Evripidis GAVATHIOTIS, Qisheng XIN, Bhaskar C. DAS
  • Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof
    Patent number: 10189827
    Abstract: Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RAR?) in subjects in need thereof.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: January 29, 2019
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Ana Maria Cuervo, Evripidis Gavathiotis, Qisheng Xin, Bhaskar C. Das
  • RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF
    Publication number: 20180141937
    Abstract: Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RAR?) in subjects in need thereof.
    Type: Application
    Filed: January 10, 2018
    Publication date: May 24, 2018
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
    Inventors: Ana Maria Cuervo, Evripidis Gavathiotis, Qisheng Xin, Bhaskar C. Das
  • Retinoic acid receptor antagonists as chaperone-mediated authophagy modulators and uses thereof
    Patent number: 9890143
    Abstract: Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RAR?) in subjects in need thereof.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: February 13, 2018
    Assignee: Albert Einstein College of Medicine, Inc.
    Inventors: Ana Maria Cuervo, Evripidis Gavathiotis, Qisheng Xin
  • RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTHOPHAGY MODULATORS AND USES THEREOF
    Publication number: 20170037039
    Abstract: Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RAR?) in subjects in need thereof.
    Type: Application
    Filed: October 20, 2016
    Publication date: February 9, 2017
    Applicant: Albert Einstein College of Medicine, Inc.
    Inventors: Ana Maria Cuervo, Evripidis Gavathiotis, Qisheng Xin, Bhaskar C. Das
  • Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof
    Patent number: 9512092
    Abstract: Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RAR?) in subjects in need thereof.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: December 6, 2016
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
    Inventors: Ana Maria Cuervo, Evripidis Gavathiotis, Qisheng Xin, Bhaskar C. Das
  • RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF
    Publication number: 20150166492
    Abstract: Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RAR?) in subjects in need thereof.
    Type: Application
    Filed: December 11, 2014
    Publication date: June 18, 2015
    Inventors: ANA MARIA CUERVO, EVRIPIDIS GAVATHIOTIS, QISHENG XIN, BHASKAR C. DAS