Patents by Inventor Ana Maria OVALLE

Ana Maria OVALLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELL-CONTROLLED PERFUSION IN CONTINUOUS CULTURE
    Publication number: 20230242857
    Abstract: Methods of protein production in continuous perfusion mammalian cell culture bioreactors are provided. Methods for continuous perfusion culture by allowing cells to self-regulate the rate of addition of perfusion medium to the bioreactor via a pH change are presented. Compositions comprising the perfusion medium as well as the process advantages of using hi-end pH control of perfusion or HIPCOP are also presented.
    Type: Application
    Filed: January 30, 2023
    Publication date: August 3, 2023
    Inventors: Gregory Walter HILLER, Matthew Paul GAGNON, Ana Maria OVALLE
  • Cell-controlled perfusion in continuous culture
    Patent number: 11597903
    Abstract: Methods of protein production in continuous perfusion mammalian cell culture bioreactors are provided. Methods for continuous perfusion culture by allowing cells to self-regulate the rate of addition of perfusion medium to the bioreactor via a pH change are presented. Compositions comprising the perfusion medium as well as the process advantages of using hi-end pH control of perfusion or HIPCOP are also presented.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: March 7, 2023
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Gregory Walter Hiller, Matthew Paul Gagnon, Ana Maria Ovalle
  • CELL-CONTROLLED PERFUSION IN CONTINUOUS CULTURE
    Publication number: 20180171279
    Abstract: Methods of protein production in continuous perfusion mammalian cell culture bioreactors are provided. Methods for continuous perfusion culture by allowing cells to self-regulate the rate of addition of perfusion medium to the bioreactor via a pH change are presented. Compositions comprising the perfusion medium as well as the process advantages of using hi-end pH control of perfusion or HIPCOP are also presented.
    Type: Application
    Filed: May 27, 2016
    Publication date: June 21, 2018
    Inventors: Gregory Walter HILLER, Matthew Paul GAGNON, Ana Maria OVALLE