Abstract: The invention relates to a genetically modified fungal microorganism for the production of frambinone, the microorganism having the following characteristics: —the capacity to produce frambinone from tyrosine; and —a limited capacity or no capacity to break tyrosine down into tyrosol, p-hydroxyphenylacetaldehyde and/or p-hydroxyphenylacetate; and to the use of same for producing frambinone.

Abstract: A thumb brace for at least partially immobilizing a thumb of a user is provided. The thumb brace includes a first curved support element configured to be disposed on a heel of a hand along an intercarpal articulation of the thumb and in a palmar gutter of the hand. The thumb brace includes a second curved support element coupled to the first curved support element and configured to be disposed on a palm of the hand along a metacarpophalangeal joint of the thumb. The thumb brace includes a third curved support element configured to be disposed on a backside of the hand along the intercarpal articulation of the thumb. The thumb brace includes a fourth curved support element coupled to the third curved support element and configured to be disposed on the backside of the hand along the metacarpophalangeal joint of the thumb. Related methods are also provided.

Abstract: The invention relates to a genetically modified fungal microorganism for the production of frambinone, said microorganism having the following characteristics: —the capacity to produce frambinone from tyrosine; and —a limited capacity or no capacity to break tyrosine down into tyrosol, p-hydroxyphenylacetaldehyde and/or p-hydroxyphenylacetate; and to the use of same for producing frambinone.

Abstract: The invention relates to a genetically modified fungal microorganism for the production of frambinone, the microorganism having the following characteristics: —the capacity to produce frambinone from tyrosine; and —a limited capacity or no capacity to break tyrosine down into tyrosol, p-hydroxyphenylacetaldehyde and/or p-hydroxyphenylacetate; and to the use of same for producing frambinone.

Abstract: The invention relates to a genetically modified fungal microorganism for the production of frambinone, said microorganism having the following characteristics: —the capacity to produce frambinone from tyrosine; and —a limited capacity or no capacity to break tyrosine down into tyrosol, p-hydroxyphenylacetaldehyde and/or p-hydroxyphenylacetate; and to the use of same for producing frambinone.