Abstract: Disclosed herein are neuronal cell activity reporter systems including a Secreted Neuronal Activity Reporter (SNAR) construct and a control construct. The SNAR construct includes four tandem repeats of a core domain of the Synaptic Activity Response Element (SARE) of Arc/Arg3.1, a polynucleotide comprising the Arc minimal promoter, and a polynucleotide encoding a first secreted reporter protein. The control construct includes a constitutive promoter and a polynucleotide encoding a second secreted reporter protein. Further provided are methods of monitoring neuronal activity in a cell. The methods may include administering to a cell the neuronal cell activity reporter system, contacting with a substrate, and measuring a signal.

Abstract: The present invention relates to compositions comprising mesenchymal stem cells (MSC) useful for producing pharmaceutical formulation to treat musculoskeletal conditions, including joint degeneration, tendon and ligament laxity or rupture, and muscle conditions. The present invention relates to the field of regenerative medicine, namely formulating improved compositions for the treatment of musculoskeletal conditions, including joint degeneration, tendon and ligament laxity or rupture, and muscle conditions, having a positive impact on pharmaceutical formulations containing mesenchymal stem cells (MSCs), providing the enhancement of MSCs viability upon cryopreservation, MSCs stability during transportation and manipulation, and MSCs therapeutic efficacy of the final formulations.

Abstract: Methods and systems for controlling optical power attenuation are provided. A method comprises periodically measuring an optical power of an optical signal received by an optical receiver and periodically measuring a first attenuation control signal voltage. When the optical power measurement is outside a target power range, the method continues with calculating a target voltage necessary to maintain the optical power measurements at a target power level; calculating a second attenuation control signal based on the target voltage, wherein the second attenuation control signal is calculated to provide an over-damped transient response that maintains the second attenuation control signal within a usable range of a variable optical power attenuator; applying a second attenuation control signal voltage based on the second attenuation control signal to the variable optical power attenuator; and adjusting attenuation of the optical signal based on the second attenuation control signal voltage.

Abstract: Methods and systems for controlling power in a communications network are provided. In one embodiment, a method comprises reading a power level of a communication link; and, driving an attenuation control signal based on the power level of the communication link. When the power level is greater than or equal to a minimum supported power level, driving an attenuation control signal further comprises constraining the attenuation control signal to a calibrated range of a characteristic curve. When one or both of the power level is less than the minimum supported power level and a bit error rate is greater than a maximum error threshold, driving an attenuation control signal further comprises generating an attenuation control signal outside the calibrated range of the characteristic curve.

Abstract: Methods and systems for controlling power in a communications network are provided. In one embodiment, a method comprises reading a power level of a communication link; and, driving an attenuation control signal based on the power level of the communication link. When the power level is greater than or equal to a minimum supported power level, driving an attenuation control signal further comprises constraining the attenuation control signal to a calibrated range of a characteristic curve. When one or both of the power level is less than the minimum supported power level and a bit error rate is greater than a maximum error threshold, driving an attenuation control signal further comprises generating an attenuation control signal outside the calibrated range of the characteristic curve.

Abstract: Methods and systems for controlling optical power attenuation are provided. A method comprises periodically measuring an optical power of an optical signal received by an optical receiver and periodically measuring a first attenuation control signal voltage. When the optical power measurement is outside a target power range, the method continues with calculating a target voltage necessary to maintain the optical power measurements at a target power level; calculating a second attenuation control signal based on the target voltage, wherein the second attenuation control signal is calculated to provide an over-damped transient response that maintains the second attenuation control signal within a usable range of a variable optical power attenuator; applying a second attenuation control signal voltage based on the second attenuation control signal to the variable optical power attenuator; and adjusting attenuation of the optical signal based on the second attenuation control signal voltage.

Abstract: An adjustable head harness for supporting an interface device near a face of a head includes a headband section, an adjustable crown support section, an upper support section and a lower support section. The headband section is adapted to fit over a portion of the head and configured to secure the adjustable head harness to the head. The headband section has connectors disposed at selected portions of the headband section. The adjustable crown support section is configured to prevent a slipping of the headband section in a downward direction with respect to a top of the head. The adjustable crown support section traverses the top of the head in a crisscross fashion and is connected to the headband section via the connectors. The upper support section is disposed at a portion of the headband section corresponding to the face. The upper support section supports the interface device at a first location.