Abstract: The present disclosure relates generally to adeno-associated vims (AAV) capsid polypeptides and encoding nucleic acid molecules. The disclosure also relates to AAV vectors comprising the capsid polypeptides, and nucleic acid vectors (e.g. plasmids) comprising the encoding nucleic acids molecules, as well as to host cells comprising the vectors. The disclosure also relates to methods and uses of the polypeptides, encoding nucleic acids molecules, vectors and host cells.

Abstract: The present invention relates to the identification of photoreceptors or cone photoreceptors in populations of cells. In particular the present invention relates to methods of identification of photoreceptors or cone photoreceptors and methods of isolating photoreceptors or cone photoreceptors. Photoreceptors or cone photoreceptors isolated by the methods of the present invention are useful for transplantation and the treatment of retinal dystrophies. Also claimed are human cell populations enriched for photoreceptors or cone photoreceptors and kits for identifying photoreceptors or cone photoreceptors.