Abstract: The present technology relates to film forming compositions comprising antimicrobial agents, as well as to methods of inhibiting bacterial growth, controlling the rate of release of an antimicrobial agent from a film forming polymer, coating a medical device, rendering the inner lumen of a medical device biofilm resistant, and treating a human or animal.

Abstract: Disclosed herein are compositions useful for coating medical devices which have antimicrobial (anti-infective) qualities and which are simple to manufacture and cost-effective, and therefore suitable for global use, including in developing countries with economic constraints, and in a cost-conscious healthcare environment. In one embodiment, disclosed are formulations that include chlorhexidine (CHX), curcumin (CUR), for example, curcumin C3 complex, and a silver (Ag) salt. Other embodiments pertain to compositions that include CHX, Ag and a lubricating agent. The antimicrobial coatings made according to embodiments of the invention are easier to produce, have superior efficacy and devices coated with this composition show initial release of antimicrobials and prolonged prevention of bacterial adherence, compared to currently available alternatives, to significantly reduce device-related infection especially catheter associated urinary tract infection.