Abstract: A method of preparing spray dried particles for inhalation comprising providing: (i) an aqueous liquid composition including the alginate oligomer and an aqueous liquid composition including an anti-adherent compound, or (ii) an aqueous liquid composition including the alginate oligomer and an anti-adherent compound; providing an organic liquid composition including a phospholipid; combining a volume of the organic liquid composition with a volume of the aqueous liquid composition, wherein the total volume of the organic liquid composition is smaller than the total volume of the aqueous liquid composition with which it is combined, and wherein the total volume of aqueous liquid composition and said total volume of organic liquid composition are sufficient to provide a combination; homogenizing the combination to form an organic-in-aqueous liquid emulsion for spray drying; and spray drying the organic-in-aqueous liquid emulsion to form the spray dried particles for inhalation.

Abstract: Spray dried particles are for inhalation. The particles consist of (i) at least about 70% w/w of an alginate oligomer, (ii) at least about 10% w/w in total of a phospholipid and an anti-adherent compound. and (iii) no greater than about 10% w/w of further excipients. The phospholipid is solid at room temperature, and is present at no less than 0.5% w/w. The anti-adherent compound is present at no less than 0.5% w/w. The particles, capsules and dry powder inhalers including the particles can be for therapeutic use, such as in the treatment or reduction of likelihood of a respiratory infection or a respiratory disorder.