Abstract: Sleep apnea can be treated using positive airway pressure. Methods and systems for determining a level of airway obstruction allow beneficial adjustments to the level of expiratory positive airway pressure used to treat a subject.

Abstract: The present disclosure pertains to a system configured to detect slow waves in a subject during a sleep session. The system generates output signals conveying information related to brain activity of the subject. The system is configured to detect individual sleep stages of the subject, the individual sleep stages including a deep sleep stage; and, responsive to detecting the deep sleep stage, generate a harmonic representation of the output signals for a period of time during the sleep session that includes the deep sleep stage; identify two or more points of significance on the harmonic representation of the output signals; and analyze a shape of the harmonic representation of the output signals around the two or more points of significance to determine whether the shape of the harmonic representation of the output signals around the two or more points of significance corresponds to a shape of a slow wave.

Abstract: A pressurized flow of breathable gas is delivered to the airway of a subject in accordance with a therapy regimen. The therapy regimen calls for maintenance of an average tidal volume. The therapy ensures that the subject breaths at a therapeutic breath rate. The breath rate may be determined dynamically based on breathing of the subject early on in a therapy session and/or based on a detected wakefulness of the subject. Inspiration for spontaneous and non-spontaneous breaths may be supported at different levels. The therapy regimen further maintains a beneficial positive end expiratory pressure, to reduce respiratory obstructions and/or for other purposes.

Abstract: A pressurized flow of breathable gas is delivered to the airway of a subject in accordance with a therapy regimen. One or more fluid parameters of the pressurized flow of breathable gas are adjusted based on the therapy regimen. The therapy regimen dictates that such adjustments be made based on the respiratory state of the subject. Transitions in respiratory state are identified without relying on measurement or estimation of flow at or near the airway of subject. Transitions in respiratory state are identified based on changes in the first time derivative of flow at or near the airway of the subject. In one embodiment, an effort parameter is determined that approximates the second time derivative of flow. Based on comparisons of the effort parameter to a dynamic threshold, transitions in respiratory state are identified.

Abstract: The disclosed concept maintains that Qp=Qc?Qleak, where, Qp is the estimated patient flow, Qleak is the estimated leak and Qc is the measured total circuit flow. Qleak is given by a transfer function ?(?) where x is a set of independent measured or fixed variables. The transfer function is thus Qleak=?(?). The transfer function (?(?) is adjusted given the constraint that, Qp shall be zero. The transfer function converges over time to accurately estimate the leak because over an extended time the mean patient flow will always be zero. In one example, ?(?)=gorfP? and the coefficient gorf is adapted until Qp is zero.

Abstract: A portable handheld pressure support system (10) is configured to provide pressure support therapy to a subject. The pressure support system provides a pressurized flow of breathable gas that is delivered to the airway of the subject to treat COPD and/or dyspnea, hyperinflation, and/or other conditions. The system is configured to adjust an expiratory pressure level of the pressure support therapy responsive to identification of hyperinflation in the subject. The pressure support therapy provided to the subject is configured to be used as needed to rapidly alleviate shortness of breath, hyperinflation, and/or other symptoms. The pressure support system is configured to be small and lightweight so that the subject may carry the system and use the system as needed.

Abstract: A portable handheld pressure support system (10) is configured to provide rapid recovery from dyspnea of a subject (12). The pressure support system (10) is configured to be small and lightweight so that the subject (12) may carry the system (10) and use the system (10) as needed without requiring a device to be worn on the face. The system (10) comprises one or more of a pressure generator (14), a subject interface (16), a medicament inlet port (21), one or more sensors (18), one or more valves (19), one or more processors (20), a user interface (22), electronic storage (24), a portable power source (26), a housing (28), a handle (30), and/or other components.

Abstract: The present disclosure pertains to a portable handheld pressure support system configured to deliver a blending gas enriched pressurized flow of breathable gas to the airway of a subject. The pressure support system is configured to treat patients suffering from dyspnea and/or other conditions. The therapy provided to dyspnea patients is configured to be used as needed by a subject to rapidly alleviate shortness of breath. The pressure support system is configured to be small and lightweight so that the subject may carry the system and use the system as needed without requiring a device to be worn on the face. In some embodiments, the system comprises one or more of a pressure generator, a subject interface, a blending gas inlet port, one or more sensors, a valve, one or more processors, a user interface, electronic storage, a portable power source, a housing, a handle, and/or other components.

Abstract: The present disclosure pertains to a portable handheld pressure support system configured to deliver a pressurized flow of breathable gas to the airway of a subject. The pressure support system is configured to treat COPD and/or other patients suffering from dyspnea and/or other conditions. The pressure support system is configured to be small and lightweight so that a subject may carry the system and use the system as needed without requiring a device to be worn on the face. The present disclosure contemplates that the portable handheld pressure support system may be used to treat symptoms and/or conditions related to dyspnea, and/or for other uses. In one embodiment, the system comprises one or more of a pressure generator, a subject interface, one or more sensors, one or more processors, a user interface, electronic storage, a portable power source, a housing, a handle, and/or other components.

Abstract: A method of estimating the upper airway resistance of a patient using a gas delivery system includes delivering a flow of breathing gas to the patient through the patient circuit of the gas delivery system, superimposing an oscillatory pressure on the flow of breathing gas during an expiratory phase of the patient, determining a first amplitude of an oscillatory component of a gas pressure provided to the patient at an end of the expiratory phase, determining a second amplitude of an oscillatory component of a gas flow provided to the patient at the end of the expiratory phase, determining a first resistance value based on the ratio of the first amplitude to the second amplitude, and determining an upper airway resistance value based on the first resistance value.

Abstract: Sleep apnea can be treated using positive airway pressure. Methods and systems for determining a level of airway obstruction allow beneficial adjustments to the level of expiratory positive airway pressure used to treat a subject.

Abstract: A pressurized flow of breathable gas is delivered to the airway of a subject in accordance with a therapy regimen. One or more fluid parameters of the pressurized flow of breathable gas are adjusted based on the therapy regimen. The therapy regimen dictates that such adjustments be made based on the respiratory state of the subject. Transitions in respiratory state are identified without relying on measurement or estimation of flow at or near the airway of subject. Transitions in respiratory state are identified based on changes in the first time derivative of flow at or near the airway of the subject. In one embodiment, an effort parameter is determined that approximates the second time derivative of flow. Based on comparisons of the effort parameter to a dynamic threshold, transitions in respiratory state are identified.

Abstract: A pressurized flow of breathable gas is delivered to the airway of a subject in accordance with a therapy regimen. The therapy regimen calls for maintenance of an average tidal volume. The therapy ensures that the subject breaths at a therapeutic breath rate. The breath rate may be determined dynamically based on breathing of the subject early on in a therapy session and/or based on a detected wakefulness of the subject. Inspiration for spontaneous and non-spontaneous breaths may be supported at different levels. The therapy regimen further maintains a beneficial positive end expiratory pressure, to reduce respiratory obstructions and/or for other purposes.

Abstract: The disclosed concept maintains that Qp=Qc?Qleak, where, Qp is the estimated patient flow, Qleak is the estimated leak and Qc is the measured total circuit flow. Qleak is given by a transfer function ?(?) where x is a set of independent measured or fixed variables. The transfer function is thus Qleak=?(?). The transfer function (?(?) is adjusted given the constraint that, Qp shall be zero. The transfer function converges over time to accurately estimate the leak because over an extended time the mean patient flow will always be zero. In one example, ?(?)=g,orfP?and the coefficient gorf is adapted until Qp is zero.

Abstract: General diagnostic and real-time application of digital Hermite functions allows features to be extracted from a measured signal through expansion of the measured signal. Specifically, the digital Hermite functions represent the shape of the measured signal in a set of vectors derived from a symmetrical tridiagonal matrix. This allows for efficient computation of the Hermite expansion coefficients, in real-time, to represent the expanded signal. The signal expansion also allows any artifacts, such as noise, to be isolated and removed, allowing the underlying signal of interest to be revealed.

Abstract: The present invention relates to general diagnostic and real-time applications of discrete Hermite functions to digital data. More specifically, the invention relates to methods and systems for the application of dilated discrete digital Hermite functions (DDHF) to biomedical data, for example, to extract features from digital signals, including but not limited to, ECGs, EMGs, EOGs, EEGs, and others, by expanding the measured signals using a computationally efficient technique. These digital Hermite functions form the basis for the new discrete Hermite transform, generated on a beat by beat basis, which provides information about the shape of the signals, such as that in the BCG artifact in an EEG or in an ECG interval, or any noise in any other electrical signal. An automated system and method for real-time interpretation of any abnormalities present in a digital biomedical signal is provided.