Patents by Inventor Anantha Sudhakar

Anantha Sudhakar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,8-naphthyridine compounds for the treatment of cancer
    Patent number: 8124773
    Abstract: Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: February 28, 2012
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Daniel C. Adelman, Marc J. Evanchik, Anantha Sudhakar, Jeffrey William Jacobs, Jeffrey A. Silverman
  • Exo- and diastereo-selective syntheses of himbacine analogs
    Patent number: 7989653
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: August 2, 2011
    Assignee: Schering Corporation
    Inventors: George G. Wu, Anantha Sudhakar, Tao Wang, Ji Xie, Frank X. Chen, Marc Poirier, Mingsheng Huang, Vijay Sabesan, Daw-Iong Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram K. Thiruvengadam, Jing Liao, Ilia Zavialov, Hoa N. Nguyen, Ngiap Kie Lim
  • COMPOUNDS AND METHODS FOR TREATMENT OF CANCER
    Publication number: 20110105497
    Abstract: Compounds for treating, preventing or managing cancer are disclosed. Also provided are methods for using the compounds in treatment of various cancers. Also provided are methods of treatment using the compounds together with another chemotherapy, radiation therapy, hormonal therapy, biological therapy, or immunotherapy. Pharmaceutical compositions suitable for use in the methods are also disclosed.
    Type: Application
    Filed: October 26, 2010
    Publication date: May 5, 2011
    Inventor: Anantha Sudhakar
  • STABLE SNS-595 COMPOSITIONS AND METHODS OF PREPARATION
    Publication number: 20110086876
    Abstract: Methods of preparing substantially pure SNS-595 substance are disclosed. Also provided are compositions comprising SNS-595 substance that are substantially pure and essentially free of visible particles.
    Type: Application
    Filed: December 30, 2010
    Publication date: April 14, 2011
    Inventors: Anantha Sudhakar, Jeff Jacobs, Ahmad Hashash, Sean Ritchie, Hengqin Cheng
  • Stable SNS-595 Compositions and Methods of Preparation
    Publication number: 20110082169
    Abstract: Methods of preparing substantially pure SNS-595 substance are disclosed. Also provided are compositions comprising SNS-595 substance that are substantially pure and essentially free of visible particles.
    Type: Application
    Filed: September 3, 2010
    Publication date: April 7, 2011
    Inventors: Anantha SUDHAKAR, Jeff Jacobs, Ahmad Hashasb, Sean Ritchie, Hengqin Cheng
  • Synthesis of 2-Hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide
    Patent number: 7910775
    Abstract: Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: March 22, 2011
    Assignee: Schering Corporation
    Inventors: Jianguo Yin, Xiaoyong Fu, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • Method of preparing (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
    Publication number: 20100203162
    Abstract: Methods of preparing (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid are disclosed. Also provided are pharmaceutical compositions comprising (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid, and methods of treatment using such compositions.
    Type: Application
    Filed: December 30, 2009
    Publication date: August 12, 2010
    Inventors: Anantha Sudhakar, Tamilarasan Subramani, Mohamed Sheik Mohamed Mujeebur Rahuman, Ramar Subbiah
  • COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF CANCER
    Publication number: 20100029708
    Abstract: Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.
    Type: Application
    Filed: June 12, 2007
    Publication date: February 4, 2010
    Inventors: Daniel C. Adelman, Marc J. Evanchik, Anantha Sudhakar, Jeffrey William Jacobs, Jeffrey A. Silverman
  • SYNTHESIS OF 2-HYDROXY-N,N-DIMETHYL-3-[[2-[[1(R)-(5-METHYL-2-FURANYL)PROPYL]AMINO]-3,4-DIOXO-1-CYCLOBUTEN-1-YL]AMINO]BENZAMIDE
    Publication number: 20090048458
    Abstract: Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
    Type: Application
    Filed: October 17, 2008
    Publication date: February 19, 2009
    Inventors: Jianguo Yin, Xiaoyong FU, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[[1(r)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide
    Patent number: 7462740
    Abstract: Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
    Type: Grant
    Filed: May 9, 2006
    Date of Patent: December 9, 2008
    Assignee: Schering Corporation
    Inventors: Jianguo Yin, Xiaoyong Fu, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof
    Publication number: 20080114179
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Application
    Filed: November 6, 2007
    Publication date: May 15, 2008
    Inventors: Jeonghan Park, Anantha Sudhakar, George Wong, Minzhang Chen, Juergen Weber, Xiaojing Yang, Daw Kwok, Ingyu Jeon, Ramani Raghavan, Maria Tamarez, Weidong Tong, Eugene Vater
  • Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl
    Patent number: 7326795
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: February 5, 2008
    Assignee: Schering Corporation
    Inventors: Anantha Sudhakar, Vilas Dahanukar, Ilia A. Zavialov, Cecilia Orr, Hoa N. Nguyen, Juergen Weber, Ingyu Jeon, Minzhang Chen, Michael D. Green, George S. Wong, Jeonghan Park, Tetsuo Iwama
  • Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof
    Patent number: 7309717
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: December 18, 2007
    Assignee: Schering Corporation
    Inventors: Jeonghan Park, Anantha Sudhakar, George S. Wong, Minzhang Chen, Juergen Weber, Xiaojing Yang, Daw-Jong Kwok, Ingyu Jeon, Ramani R. Raghavan, Maria Tamarez, Weidong Tong, Eugene J. Vater
  • Exo- and diastereo- selective syntheses of himbacine analogs
    Publication number: 20060247450
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Application
    Filed: January 12, 2006
    Publication date: November 2, 2006
    Inventors: George Wu, Anantha Sudhakar, Tao Wang, Ji Xie, Frank Chen, Marc Poirier, Mingsheng Huang, Vijay Sabesan, Daw-long Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram Thiruvengadam, Jing Liao, Ilia Zavialov, Hoa Nguyen, Ngiap Lim
  • Synthesis of quinoline 5-carboxamides useful for the preparation of PDE IV inhibitors
    Patent number: 7129357
    Abstract: In one embodiment, the present application discloses a process for making the compound of the formula:
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: October 31, 2006
    Assignee: Schering Corporation
    Inventors: David R. Andrews, Suhan Tang, Wenxue Wu, Sami Y. Kalliney, Anantha Sudhakar, Christopher Nielsen
  • Exo-selective synthesis of himbacine analogs
    Publication number: 20060217422
    Abstract: This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists.
    Type: Application
    Filed: January 12, 2006
    Publication date: September 28, 2006
    Inventors: Tiruvettipuram Thiruvengadam, Anantha Sudhakar, Ngiap Lim, Daw-long Kwok, George Wu, Tao Wang, Mingsheng Huang, Michael Green
  • Synthesis of 2-hydroxy-N,N-dimethyl-3-[[2-(1(R)-(5-methyl-2-furany)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide
    Publication number: 20060205961
    Abstract: Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
    Type: Application
    Filed: May 9, 2006
    Publication date: September 14, 2006
    Inventors: Jianguo Yin, Xiaoyong Fu, Shuyi Zhang, Timothy McAllister, Agnes Kim-Meade, Jason Winters, Anantha Sudhakar, Doris Schumacher
  • Synthesis of 2-hydroxy-N,N-dimethyl-3-[ [2-[1 (R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide
    Patent number: 7071342
    Abstract: Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1–C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: July 4, 2006
    Assignee: Schering Corporation
    Inventors: Jianguo Yin, Xiaoyong Fu, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • Crystalline antifungal polymorph
    Patent number: 6958337
    Abstract: The crystalline polymorph Form I of (?)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methoxy]phenyl]-1-piperazinyl]phenyl-2,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxylpropyl]-3H-1,2,4-triazol-3-one represented by the formula I pharmaceutical compositions containing such a polymorph and methods of using such a polymorph to treat fungal infections in mammals are disclosed.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: October 25, 2005
    Assignee: Schering Corporation
    Inventors: David R. Andrews, William Leong, Anantha Sudhakar
  • Synthesis of quinoline 5-carboxamides useful for the preparation of PDE IV inhibitors
    Publication number: 20050124655
    Abstract: In one embodiment, the present application discloses a process for making the compound of the formula:
    Type: Application
    Filed: September 13, 2004
    Publication date: June 9, 2005
    Inventors: David Andrews, Suhan Tang, Wenxue Wu, Sami Kalliney, Anantha Sudhakar, Christopher Nielsen