Patents by Inventor Anastasia M. Khoury-Christianson

Anastasia M. Khoury-Christianson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of human hemoglobin in transgenic pigs
    Patent number: 6147202
    Abstract: The present invention relates to the use of transgenic pigs for the production of human hemoglobin. The transgenic pigs of the invention may be used as an efficient and economical source of cell-free human hemoglobin that may be used for transfusions and other medical applications in humans.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: November 14, 2000
    Inventors: Ramesh Kumar, Ajay Sharma, Clara Paulhiac, Anastasia M. Khoury-Christianson, Sunita Midha
  • Hemoglobin comprising globin fusion proteins
    Patent number: 5627268
    Abstract: The present invention relates to a novel method for making a predetermined, desired peptide in transgenic animals and can be advantageously used for the production of large quantities of the desired peptide. More particularly, the invention concerns the engineering of a transgenic animal having an artificial gene, which is controlled by globin locus control region (LCR) and which encodes a fusion protein, in which the desired peptide is joined via a cleavable peptide linker to a globin polypeptide. The erythrocytes of the transgenic animal express the fusion globin which is incorporated into hemoglobin produced by the host cell. The desired peptide can be obtained from a hemolysate of the red cells of the transgenic animals by enzymatic or chemical cleavage at the linker.
    Type: Grant
    Filed: June 7, 1994
    Date of Patent: May 6, 1997
    Assignee: DNX BioTherapeutics
    Inventors: Ramesh Kumar, Ajay Sharma, Anastasia M. Khoury-Christianson