Abstract: The present invention is directed to anti-PVRIG antibodies and stable liquid pharmaceutical formulations thereof. The present invention is directed to monotherapy and combination treatments with anti-PVRIG antibodies and anti-PD-1 antibodies, in particular nivolumab, using stable liquid pharmaceutical formulations thereof.

Abstract: A non-removable insole, that is an integral part of a shoe or other footwear article, includes at least: a top layer, a middle layer, and a bottom layer. The middle layer of the insole has apertures or cavities, that define several discrete storage chambers within the insole. Each storage chamber stores a mixture of two or more particulate materials. The mixture includes one or more materials selected from Group A, which includes natural sand, synthetic sand, artificial sand, kinetic sand, silica, quartz. The mixture further includes one or more materials selected from Group B, which includes: powdered aluminum, powdered titanium, powdered zinc, powdered magnesia, powdered silver, powdered anti-bacterial agent, powdered metal, powdered talcum, grained cork, grained coal, grained wood.

Abstract: The present invention is directed to anti-PVRIG antibodies and stable liquid pharmaceutical formulations thereof. The present invention is directed to monotherapy and combination treatments with anti-PVRIG antibodies and anti-PD-1 antibodies, in particular nivolumab, using stable liquid pharmaceutical formulations thereof. The present invention also provides biomarkers for use in determining populations for treatment with anti-PVRIG antibodies and such biomarkers include, for example PVRIG and/or PVRL2 expression.

Abstract: A non-removable insole, that is an integral part of a shoe or other footwear article, includes at least: a top layer, a middle layer, and a bottom layer. The middle layer of the insole has apertures or cavities, that define several discrete storage chambers within the insole. Each storage chamber stores a mixture of two or more particulate materials. The mixture includes one or more materials selected from Group A, which includes natural sand, synthetic sand, artificial sand, kinetic sand, silica, quartz. The mixture further includes one or more materials selected from Group B, which includes: powdered aluminum, powdered titanium, powdered zinc, powdered magnesia, powdered silver, powdered anti-bacterial agent, powdered metal, powdered talcum, grained cork, grained coal, grained wood.

Abstract: An insole, which is insertable into a shoe and is removable from the shoe, includes at least a top layer, a middle layer, and a bottom layer. The middle layer has apertures or cavities, that define several discrete storage chambers within the insole. Each storage chamber stores a mixture of two or more particulate materials. The mixture includes one or more materials selected from Group A, which includes natural sand, synthetic sand, artificial sand, kinetic sand, silica, quartz. The mixture further includes one or more materials selected from Group B, which includes: powdered aluminum, powdered titanium, powdered zinc, powdered magnesia, powdered silver, powdered anti-bacterial agent, powdered metal, powdered talcum, grained cork, grained coal, grained wood.

Abstract: An insole, which is insertable into a shoe and is removable from the shoe, includes at least a top layer, a middle layer, and a bottom layer. The middle layer has apertures or cavities, that define several discrete storage chambers within the insole. Each storage chamber stores a mixture of two or more particulate materials. The mixture includes one or more materials selected from Group A, which includes natural sand, synthetic sand, artificial sand, kinetic sand, silica, quartz. The mixture further includes one or more materials selected from Group B, which includes: powdered aluminum, powdered titanium, powdered zinc, powdered magnesia, powdered silver, powdered anti-bacterial agent, powdered metal, powdered talcum, grained cork, grained coal, grained wood.