Patents by Inventor Anatoliy V. Popov
Anatoliy V. Popov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11813338Abstract: The invention relates to compositions and methods for diagnosing as well as treating cancer diseases associated with choline kinase (ChoK). Specifically, the invention relates to a composition comprising an intrinsically fluorescent choline kinase (ChoK) inhibitor or a ChoK inhibitor operably linked to a fluorescent dye. The composition is capable of diagnosing and/or treating cancer diseases associated with ChoK.Type: GrantFiled: March 12, 2014Date of Patent: November 14, 2023Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Edward J. Delikatny, Anatoliy V. Popov, Sean P. Arlauckas
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Publication number: 20220265234Abstract: Contrast agents for x-ray imaging including stabilized metal nanoparticles and encapsulated nanoparticles, as well as methods for imaging tissue with these agents, are disclosed. Also disclosed are methods of dual energy x-ray imaging using metal nanoparticle contrast agents or encapsulated metal nanoparticles.Type: ApplicationFiled: April 1, 2022Publication date: August 25, 2022Inventors: Andrew D.A. Maidment, Anatoliy V. Popov, E James Delikatny, Andrew Tsourkas, Roshan Karunamuni, Ajlan Al Zaki, Sara Gavenonis, fDavid Cormode
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Patent number: 11337665Abstract: Contrast agents for x-ray imaging including stabilized metal nanoparticles and encapsulated nanoparticles, as well as methods for imaging tissue with these agents, are disclosed. Also disclosed are methods of dual energy x-ray imaging using metal nanoparticle contrast agents or encapsulated metal nanoparticles.Type: GrantFiled: March 13, 2014Date of Patent: May 24, 2022Assignee: The Trustees of the University of PennsylvaniaInventors: Andrew D. A. Maidment, Anatoliy V. Popov, E. James Delikatny, Andrew Tsourkas, Roshan Karunamuni, Ajlan Al Zaki, Sara Gavenonis, David Cormode
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Patent number: 11034994Abstract: The present invention is directed to a phospholipid-based NIR molecular beacon, having a phospholipid moiety; with an NIR fluorophore moiety covalently linked to a phospholipid glycerol backbone and a quencher moiety covalently linked to the phospholipid glycerol backbone. Additionally, provided herein is methods of analyzing a sample for the presence of a phospholipase and methods of identifying the activity of a phospholipase in vivo utilizing phospholipid-based NIR molecular beacon.Type: GrantFiled: April 30, 2018Date of Patent: June 15, 2021Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Edward J. Delikatny, Anatoliy V. Popov, Gang Zheng, Theresa Mawn
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Publication number: 20180245129Abstract: The present invention is directed to a phospholipid-based NIR molecular beacon, having a phospholipid moiety; with an NIR fluorophore moiety covalently linked to a phospholipid glycerol backbone and a quencher moiety covalently linked to the phospholipid glycerol backbone. Additionally, provided herein is methods of analyzing a sample for the presence of a phospholipase and methods of identifying the activity of a phospholipase in vivo utilizing phospholipid-based NIR molecular beacon.Type: ApplicationFiled: April 30, 2018Publication date: August 30, 2018Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Edward J. DELIKATNY, Anatoliy V. Popov, Gang Zheng, Theresa Mawn
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Patent number: 9957546Abstract: The present invention is directed to a phospholipid-based NIR molecular beacon, having a phospholipid moiety; with an NIR fluorophore moiety covalently linked to a phospholipid glycerol backbone and a quencher moiety covalently linked to the phospholipid glycerol backbone. Additionally, provided herein is methods of analyzing a sample for the presence of a phospholipase and methods of identifying the activity of a phospholipase in vivo utilizing phospholipid-based NIR molecular beacon.Type: GrantFiled: March 3, 2009Date of Patent: May 1, 2018Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: E. J. Delikatny, Anatoliy V. Popov, Gang Zheng, Theresa Mawn
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Publication number: 20160220703Abstract: The invention relates to compositions and methods for diagnosing as well as treating cancer diseases associated with choline kinase (ChoK). Specifically, the invention relates to a composition comprising an intrinsically fluorescent choline kinase (ChoK) inhibitor or a ChoK inhibitor operably linked to a fluorescent dye. The composition is capable of diagnosing and/or treating cancer diseases associated with ChoK.Type: ApplicationFiled: March 12, 2014Publication date: August 4, 2016Applicant: The Trustees of the University of PennsylvaniaInventors: Edward J. DELIKATNY, Anatoliy V. POPOV, Sean P. ARLAUCKAS
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Publication number: 20160038111Abstract: Contrast agents for x-ray imaging including stabilized metal nanoparticles and encapsulated nanoparticles, as well as methods for imaging tissue with these agents, are disclosed. Also disclosed are methods of dual energy x-ray imaging using metal nanoparticle contrast agents or encapsulated metal nanoparticles.Type: ApplicationFiled: March 13, 2014Publication date: February 11, 2016Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: ANDREW D.A. MAIDMENT, ANATOLIY V. POPOV, E. JAMES DELIKATNY, ANDREW TSOURKAS, ROSHAN KARUNAMUNI, AJLAN AL ZAKI, SARA GAVENONIS, DAVID CORMODE
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Publication number: 20140369933Abstract: Fluorine-containing molecules include fluorine-18 labeled hydrogen ion indicator molecules and methods of making and using the same. Fluorine atoms incorporated into the indicator molecules provides novel structural modifications to the precursor molecules, shifting the absorbance maxima relative to their non-fluorinated precursor/cogeners. These molecules are useful for non-invasive in vivo measurement of blood volume, blood flow and pH in biological objects. Compounds are functionalized by a radioisotopically enriched fluorine-18 label and indicator molecule with structure derived from triarylmethane derived indicators, such as phenol red, cresol red, cresol purple, thymol blue, bromophenol red, naphthol blue, phenolphthalein, cresolphthalein, thymolphthalein, naphtholphthalein, gentian violet (methyl violet 10B), methyl violet 2B, methyl violet 6B, leucomalachite green (malachite green), brilliant green, pararosaniline, fuchsines, or salts thereof.Type: ApplicationFiled: October 9, 2012Publication date: December 18, 2014Inventors: Alexander Victor Kachur, Anatoliy V. Popov, Edward James Delikatny, Joel S. Karp
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Publication number: 20110165084Abstract: The present invention is directed to a phospholipid-based NIR molecular beacon, having a phospholipid moiety; with an NIR fluorophore moiety covalently linked to a phospholipid glycerol backbone and a quencher moiety covalently linked to the phospholipid glycerol backbone. Additionally, provided herein is methods of analyzing a sample for the presence of a phospholipase and methods of identifying the activity of a phospholipase in vivo utilizing phospholipid-based NIR molecular beacon.Type: ApplicationFiled: March 3, 2009Publication date: July 7, 2011Inventors: E.J Delikatny, Anatoliy V. Popov, Gang Zheng, Theresa Mawn
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Patent number: 7470762Abstract: Acrylic polymers are made by the living radical polymerization of acrylic monomers utilizing organo halide initiators with either metal-free or metal catalysts. Moreover, block copolymers of vinyl halide monomers and acrylic monomers are described by generally polymerizing either the vinyl halide monomers or acrylic monomers utilizing an organo halide initiator in the presence of either a metal catalyst or a metal-free catalyst and subsequently polymerizing thereon the remaining type of monomer.Type: GrantFiled: August 24, 2007Date of Patent: December 30, 2008Assignee: University of PennsylvaniaInventors: Virgil Percec, Tamaz Guliashvili, Anatoliy V. Popov
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Patent number: 7345127Abstract: Acrylic polymers are made by the living radical polymerization of acrylic monomers utilizing organo halide initiators with either metal-free or metal catalysts. Moreover, block copolymers of vinyl halide monomers and acrylic monomers are described by generally polymerizing either the vinyl halide monomers or acrylic monomers utilizing an organo halide initiator in the presence of either a metal catalyst or a metal-free catalyst and subsequently polymerizing thereon the remaining type of monomer.Type: GrantFiled: January 26, 2005Date of Patent: March 18, 2008Assignee: University of PennsylvaniaInventors: Virgil Percec, Tamaz Guliashvili, Anatoliy V. Popov
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Patent number: 7026420Abstract: A living polymerization process for preparation of poly(vinyl chloride) (PVC) with controlled molecular weight and molecular weight distribution is described. The polymerization reaction can be initiated by various polyhalocarbon initiators in conjunction with non-metallic reducing single electron transfer reagents as catalysts and accelerated by electron shuttles. The process occurs at room temperature in water or water-organic solvent medium. The polymerization provides PVC with a controlled molecular weight and narrow molecular weight distribution. The halogen containing polymer compositions are useful as, among others, viscosity modifiers, impact modifiers and compatibilizers.Type: GrantFiled: November 12, 2004Date of Patent: April 11, 2006Assignee: University of PennsylvaniaInventors: Virgil Percec, Anatoliy V. Popov
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Patent number: 6911515Abstract: A living polymerization process for preparation of poly(vinyl chloride) (PVC) with controlled molecular weight and molecular weight distribution is described. The polymerization reaction can be initiated by various polyhalocarbon initiators in conjunction with non-metallic reducing single electron transfer reagents as catalysts and accelerated by electron shuttles. The process occurs at room temperature in water or water-organic solvent medium. The polymerization provides PVC with a controlled molecular weight and narrow molecular weight distribution. The halogen containing polymer compositions are useful as, among others, viscosity modifiers, impact modifiers and compatibilizers.Type: GrantFiled: June 24, 2002Date of Patent: June 28, 2005Assignee: University of PennsylvaniaInventors: Virgil Percec, Anatoliy V. Popov
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Publication number: 20030078353Abstract: A living polymerization process for preparation of poly(vinyl chloride) (PVC) with controlled molecular weight and molecular weight distribution is described. The polymerization reaction can be initiated by various polyhalocarbon initiators in conjunction with non-metallic reducing single electron transfer reagents as catalysts and accelerated by electron shuttles. The process occurs at room temperature in water or water-organic solvent medium. The polymerization provides PVC with a controlled molecular weight and narrow molecular weight distribution. The halogen containing polymer compositions are useful as, among others, viscosity modifiers, impact modifiers and compatibilizers.Type: ApplicationFiled: June 24, 2002Publication date: April 24, 2003Applicant: UNIVERSITY OF PENNSYLVANIAInventors: Virgil Percec, Anatoliy V. Popov