Patents by Inventor Anatoly Bukovsky

Anatoly Bukovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and means for producing high titer, safe, recombinant lentivirus vectors
    Patent number: 8652837
    Abstract: Lentiviral vectors modified at the 5? LTR or both the 5? and 3? LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production. The vectors can contain inducible or conditional promoters.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: February 18, 2014
    Assignee: GBP IP, LLC
    Inventors: Luigi Naldini, Thomas Dull, Anatoly Bukovsky, Deborah A. Farson, Rochelle Witt
  • METHOD AND MEANS FOR PRODUCING HIGH TITER, SAFE, RECOMBINANT LENTIVIRUS VECTORS
    Publication number: 20080241929
    Abstract: Lentiviral vectors modified at the 5? LTR or both the 5? and 3? LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production. The vectors can contain inducible or conditional promoters.
    Type: Application
    Filed: July 20, 2007
    Publication date: October 2, 2008
    Applicant: Cell Genesys, Inc.
    Inventors: Luigi Naldini, Thomas Dull, Anatoly Bukovsky, Deborah Farson, Rochelle Witt
  • Method and means for producing high titer, safe, recombinant lentivirus vectors
    Patent number: 7250299
    Abstract: Lentiviral vectors modified at the 5? LTR or both the 5? and 3? LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production. The vectors can contain inducible or conditional promoters.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: July 31, 2007
    Assignee: Cell Genesys, Inc.
    Inventors: Luigi Naldini, Thomas Dull, Anatoly Bukovsky, Deborah Farson, Rochelle Witt
  • Infectious pseudotyped lentiviral vectors lacking matrix protein and uses thereof
    Patent number: 6479281
    Abstract: Vector systems that encode viral proteins that will assemble into an infectious lentivirus particle having a deletion of the lentiviral matrix are described. In one embodiment the vectors encode a lentiviral envelope protein that contains a deletion of the cytoplasmic tail. In a second embodiment a heterologous envelope as compared to the lentivirus is used such as an envelope protein that targets an endocytic compartment.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: November 12, 2002
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Heinrich Göttlinger, Heide Reil, Anatoly Bukovsky