Patents by Inventor Anatoly Dritschilo

Anatoly Dritschilo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods And Compositions For Cancer Therapies That Include Delivery Of Halogenated Thymidines And Thymidine Phosphorylase Inhibitors In Combination With Radiation
    Publication number: 20230302034
    Abstract: Methods and formulations are provided for treating cancer and neoplastic diseases in conjunction with radiation therapy where such methods and formulations include a combination of a radiosensitizing agent that is metabolized by thymidine phosphorylase and a thymidine phosphorylase inhibitor that increases the half-life of the radiosensitizing agent.
    Type: Application
    Filed: April 2, 2023
    Publication date: September 28, 2023
    Inventors: Scott Grindrod, Mira Jung, Olga Timofeeva, Milton Brown, Anatoly Dritschilo
  • Methods and compositions for cancer therapies that include delivery of halogenated thymidines and thymidine phosphorylase inhibitors in combination with radiation
    Patent number: 11654157
    Abstract: Methods and formulations are provided for treating cancer and neoplastic diseases in conjunction with radiation therapy where such methods and formulations include a combination of a radiosensitizing agent that is metabolized by thymidine phosphorylase and a thymidine phosphorylase inhibitor that increases the half-life of the radiosensitizing agent.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: May 23, 2023
    Assignee: Shuttle Pharmaceuticals, Inc.
    Inventors: Scott Grindrod, Mira Jung, Olga Timofeeva, Milton Brown, Anatoly Dritschilo
  • Selective histone deacetylase inhibitors for the treatment of human disease
    Patent number: 11584733
    Abstract: Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: February 21, 2023
    Assignee: Shuttle Pharmaceuticals, Inc.
    Inventors: Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
  • SELECTIVE HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF HUMAN DISEASE
    Publication number: 20220363652
    Abstract: Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.
    Type: Application
    Filed: June 28, 2022
    Publication date: November 17, 2022
    Inventors: Scott Grindrod, Mira Jung, Anatoly Dritschilo
  • SELECTIVE HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF HUMAN DISEASE
    Publication number: 20220348551
    Abstract: Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.
    Type: Application
    Filed: May 10, 2021
    Publication date: November 3, 2022
    Inventors: Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
  • Selective histone deacetylase inhibitors for the treatment of human disease
    Patent number: 11407723
    Abstract: Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: August 9, 2022
    Assignee: Shuttle Pharmaceuticals, Inc.
    Inventors: Scott Grindrod, Mira Jung, Anatoly Dritschilo
  • PREDICTIVE BIOMARKERS FOR ADVERSE EFFECTS OF RADIATION THERAPY
    Publication number: 20220065863
    Abstract: Methods of treating with radiation therapy a subject having cancer, in which the method comprises administering radiation therapy to the subject. The subject does not have an increased risk of having an adverse reaction to radiation therapy. The subject has an increased risk of an adverse reaction to radiation therapy when the subject's level of each component in a component profile from a sample of the subject is altered as compared to the normal level of each component. The component profile may comprise a metabolite panel of geranyl pyrophosphate, glucose-1-phosphate, and 3-hydroxy-3-methylglutaryl-CoA; a lipid panel of LPA 18:0, LPA 16:0, LPC 20:2, CER 24:0, and LPI 16:1; or a combination of these panels. The component profile may also comprise a metabolite panel of metanephrine, tryptophan, xanthurenic acid, and pantothenate; a lipid panel of LPA 18:0, DAG 16:0/18:0, LPA 16:0, and DAG 18:1/18:1; or a combination of these panels.
    Type: Application
    Filed: September 15, 2021
    Publication date: March 3, 2022
    Applicant: Georgetown University
    Inventors: Anatoly Dritschilo, Amrita K. Cheema, Scott Grindrod, Xiaogang Zhong
  • DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF
    Publication number: 20220055988
    Abstract: Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical compositions and methods of use are also provided that utilize such compounds.
    Type: Application
    Filed: September 24, 2021
    Publication date: February 24, 2022
    Inventors: Scott GRINDROD, Mira JUNG, Milton BROWN, Anatoly DRITSCHILO
  • SELECTIVE HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF HUMAN DISEASE
    Publication number: 20210261523
    Abstract: Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.
    Type: Application
    Filed: May 10, 2021
    Publication date: August 26, 2021
    Inventors: Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
  • Selective histone deacetylase inhibitors for the treatment of human disease
    Patent number: 11034667
    Abstract: Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: June 15, 2021
    Assignee: Shuttle Pharmaceuticals, Inc.
    Inventors: Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
  • SELECTIVE HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF HUMAN DISEASE
    Publication number: 20210078963
    Abstract: Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.
    Type: Application
    Filed: January 8, 2019
    Publication date: March 18, 2021
    Inventors: Scott Grindrod, Mira Jung, Anatoly Dritschilo
  • DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF
    Publication number: 20200317611
    Abstract: Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical compositions and methods of use are also provided that utilize such compounds.
    Type: Application
    Filed: June 24, 2020
    Publication date: October 8, 2020
    Inventors: Scott GRINDROD, Mira JUNG, Milton BROWN, Anatoly DRITSCHILO
  • Dual function molecules for histone deacetylase inhibition and ataxia telangiectasia mutated activation and methods of use thereof
    Patent number: 10745352
    Abstract: Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical compositions and methods of use are also provided that utilize such compounds.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: August 18, 2020
    Assignee: Shuttle Pharmaceuticals, Inc.
    Inventors: Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
  • Dual function molecules for histone deacetylase inhibition and ataxia telangiectasia mutated activation and methods of use thereof
    Patent number: 10730834
    Abstract: Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical compositions and methods of use are also provided that utilize such compounds.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: August 4, 2020
    Assignee: Shuttle Pharmaceuticals, Inc.
    Inventors: Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
  • SELECTIVE HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF HUMAN DISEASE
    Publication number: 20200071288
    Abstract: Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.
    Type: Application
    Filed: January 9, 2018
    Publication date: March 5, 2020
    Inventors: Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
  • Methods And Compositions For Cancer Therapies That Include Delivery Of Halogenated Thymidines And Thymidine Phosphorylase Inhibitors In Combination With Radiation
    Publication number: 20190343859
    Abstract: Methods and formulations are provided for treating cancer and neoplastic diseases in conjunction with radiation therapy where such methods and formulations include a combination of a radiosensitizing agent that is metabolized by thymidine phosphorylase and a thymidine phosphorylase inhibitor that increases the half-life of the radiosensitizing agent.
    Type: Application
    Filed: January 9, 2018
    Publication date: November 14, 2019
    Inventors: Scott Grindrod, Mira Jung, Olga Timofeeva, Milton Brown, Anatoly Dritschilo
  • DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF
    Publication number: 20180057456
    Abstract: Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical compositions and methods of use are also provided that utilize such compounds.
    Type: Application
    Filed: November 6, 2017
    Publication date: March 1, 2018
    Inventors: Scott GRINDROD, Mira JUNG, Milton BROWN, Anatoly DRITSCHILO
  • DUAL FUNCTION MOLECULES FOR HISTONE DEACETYLASE INHIBITION AND ATAXIA TELANGIECTASIA MUTATED ACTIVATION AND METHODS OF USE THEREOF
    Publication number: 20180044292
    Abstract: Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical compositions and methods of use are also provided that utilize such compounds.
    Type: Application
    Filed: March 3, 2016
    Publication date: February 15, 2018
    Inventors: Scott GRINDROD, Mira JUNG, Milton BROWN, Anatoly DRITSCHILO
  • Dual function molecules for histone deacetylase inhibition and ataxia telangiectasia mutated activation and methods of use thereof
    Patent number: 9809539
    Abstract: Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical compositions and methods of use are also provided that utilize such compounds.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: November 7, 2017
    Assignee: Shuttle Pharmaceuticals, LLC
    Inventors: Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
  • PERSONALIZED METHODS FOR TREATING DISEASE BY RADIOSENSITIZATION
    Publication number: 20170266284
    Abstract: Methods are provided for treating cancer and neoplastic diseases where such methods include the administration of radiosensitizing agents.
    Type: Application
    Filed: September 18, 2015
    Publication date: September 21, 2017
    Inventors: Scott GRINDROD, Anatoly DRITSCHILO, Timothy J KINSELLA