Publication number: 20110065919
Abstract: The invention relates to novel antiviral compounds of general formula (I), where B is —N(R)2 or —O—(CH2)nN(R)2 groups, in which n is a whole number selected from 0, 1, 2, 3 and 4, each R is independently selected from C1-4 alkyl and can be identical or different, or both groups R together with a nitrogen atom, to which they are bonded, form a 5-6-membered heterocyclic ring containing 1-2 heteroatoms selected from nitrogen, oxygen and sulphur, such as pyrrolidine, piperidine, piperazine, morpholine or thyomorpholine, at which each of above-mentioned heterocyclic rings can be substituted by C1-4 alkyl, phenyl, benzyl, phenetyl, a carbonylamino —COOC1-4 alkyl group or the carbonylamino —COOC1-4 alkyl group and phenyl, which also can be substituted and have substituents selected from halogen, C1-4 alkyl, C1-4 alkoxy, and alkyl in said groups can be linear or branched; R1 is C1-4 alkoxy, phenyl optionally substituted by C1-4 alkyl or C1-4 alkoxy, halogen atoms, naphthyl; R2 is C1-4 alkyl, —S-phenyl, —S-benzyl, —O-
Type:
Application
Filed:
April 30, 2010
Publication date:
March 17, 2011
Applicant:
OOO "BINATEKH"
Inventors:
Jury G. VERKHOVSKY, Nina G. TSYSHKOVA, Rakhimdzhan A. ROZIEV, Anatoly F. TSYB, Anna Ya. GONCHAROVA, Fedor A. TROFIMOV
Publication number: 20090240048
Abstract: The invention pertains to field of organic chemistry, medicine, pharmacology, foods and cosmetics industry, particularly, to manufacturing technology of selenoxanthenes; the invention may be used in manufacturing of food supplements, pharmaceutical and cosmetic products, having bioactive properties, of a wide spectrum of activity. The proposed compound is the ?-crystalline form of 9-phenyl-symmetrical-octahydroselenoxanthene with exhibits antioxidant, detoxifying, immunomodulating, anti-atherogenic, anti-sclerotic, anabolic and hypolipidemic properties, and has the following structural formula: Its powder X-ray diffractogram (obtained from a Cu-K X-ray source) has characteristic diffractions in degrees of the diffraction angle 2theta as 6.0, 12.0, 15.0, 17.0, 19.0, 20.0, 21.5, 21.7, 20.9, 25.0, 27.0, 28.0, 29.0, 37.0; the melting point of 96.8° C. The crystalline form of the respective 9-R-symmetrical-selenoxantene product is obtained by crystallization from a weakly polar or a non-polar solvent.
Type:
Application
Filed:
March 18, 2009
Publication date:
September 24, 2009
Applicant:
MEDBIOPHARM LTD
Inventors:
Rakhimdzhan A. ROZIEV, Anatoly F. TSYB, Anna Ya. GONCHAROVA, Viktor V. KHOMICHONOK, Vladimir K. PODGORODNICHENKO