Patents by Inventor Anders Bue Klein

Anders Bue Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDE-DRUG CONJUGATES FOR TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20250025566
    Abstract: The present invention relates to a conjugated molecule for use in treatment and/or prevention of a neurodegenerative disease in a subject in need thereof, the conjugated molecule comprising a peptide and a N-methyl-D-aspartate receptor (NMDAR) antagonist, wherein the peptide is a glucagon superfamily peptide, the peptide being linked to the NMDAR antagonist either directly or through a chemical linker.
    Type: Application
    Filed: December 2, 2022
    Publication date: January 23, 2025
    Inventors: Christoffer CLEMMENSEN, Jonas Odgaard PETERSEN, Anders Bue KLEIN
  • CONJUGATES OF GLUCAGON AND AMPK ACTIVATORS
    Publication number: 20240408218
    Abstract: The present invention relates to a conjugated molecule comprising a peptide displaying at least 0.1% activity of native glucagon at the glucagon receptor, and a AMP-activated protein kinase (AMPK) activator, the peptide being covalently bonded to the AMPK activator either directly or through a linker, the conjugated molecule for use in therapy, a pharmaceutical composition comprising the conjugated molecule, a method of reducing body weight of a mammal comprising administering the conjugated molecule to the mammal, and a non-therapeutic method of reducing body weight of a mammal comprising orally administering the conjugated molecule to the mammal.
    Type: Application
    Filed: September 28, 2022
    Publication date: December 12, 2024
    Inventors: Christoffer CLEMMENSEN, Anders Bue KLEIN, Jonas Odgaard PETERSEN, Kei SAKAMOTO
  • COMPOUNDS FOR THE TREATMENT OF ACUTE BRAIN INJURY
    Publication number: 20240391865
    Abstract: The invention relates to a compound according to formula I wherein when R5 is H, and R1 and R2 form a ring system, then said compound is selected from the following compounds of formula II or formula IV or when R2 is H, and R1 and R5 form a ring system, then said compound has formula III
    Type: Application
    Filed: July 22, 2024
    Publication date: November 28, 2024
    Inventors: Anders Bue Klein, Andrew Neil Clarkson, Joshua Macdonald Houlton, Ulrike Leurs, Rasmus Prætorius Clausen, Bente Frølund, Petrine Wellendorph
  • Compounds for the treatment of acute brain injury
    Patent number: 12077495
    Abstract: The invention relates to a compound according to formula I wherein when R5 is H, and R1 and R2 form a ring system, then said compound is selected from the following compounds of formula II or formula IV or when R2 is H, and R1 and R5 form a ring system, then said compound has formula III.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: September 3, 2024
    Assignees: Københavns Universitet, Otago Innovation Ltd.
    Inventors: Anders Bue Klein, Andrew Neil Clarkson, Joshua Macdonald Houlton, Ulrike Leurs, Rasmus Prætorius Clausen, Bente Frølund, Petrine Wellendorph
  • GLP1R AGONIST NMDAR ANTAGONIST CONJUGATES
    Publication number: 20230183335
    Abstract: The present invention relates to a conjugated molecule comprising a peptide displaying at least 0.1% activity of native glucagon-like peptide 1 (GLP-1) at the GLP-1 receptor, and an N-methyl-D-aspartate receptor (NMDAR) antagonist, the peptide being covalently bonded to the NMDAR antagonist either directly or through a chemical linker, the conjugated molecule for use in therapy, pharmaceutical composition comprising the conjugated molecule, a method of reducing body weight of a mammal comprising administering the conjugated molecule to the mammal, and a non-therapeutic method of reducing body weight of a mammal comprising orally administering the conjugated molecule to the mammal.
    Type: Application
    Filed: June 3, 2021
    Publication date: June 15, 2023
    Inventors: Christoffer CLEMMENSEN, Anders Bue KLEIN, Jonas Odgaard PETERSEN, Bente Flensborg FRØLUND, Kristian STRØMGAARD
  • COMPOUNDS FOR THE TREATMENT OF ACUTE BRAIN INJURY
    Publication number: 20210122700
    Abstract: The invention relates to a compound according to formula I wherein when R5 is H, and R1 and R2 form a ring system, then said compound is selected from the following compounds of formula II or formula IV or when R2 is H, and R1 and R5 form a ring system, then said compound has formula III
    Type: Application
    Filed: February 1, 2019
    Publication date: April 29, 2021
    Inventors: Anders Bue Klein, Andrew Neil Clarkson, Joshua Macdonald Houlton, Ulrike Leurs, Rasmus Prætorius Clausen, Bente Frølund, Petrine Wellendorph