Patents by Inventor Anders Hagvall
Anders Hagvall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250249433Abstract: The invention discloses method for manufacturing agar or agarose beads, comprising the steps of: a) providing a water phase comprising an aqueous solution of agar or agarose at a temperature of 40-100° C.; b) providing an oil phase comprising a water-immiscible solvent and an emulsifier at a temperature of 40-100° C.; c) emulsifying the water phase in the oil phase to form a water-in-oil emulsion; d) cooling the water-in-oil emulsion to a temperature below a gelation temperature of the agar or agarose to form a dispersion of solidified agar or agarose beads; and e) recovering agar or agarose beads from the dispersion, wherein the emulsifier comprises a phosphate ester of an alkoxylated fatty alcohol.Type: ApplicationFiled: February 11, 2025Publication date: August 7, 2025Inventors: Susanna Lindberg, Jonas Gustafsson, Linn Carlsson, Anders Hagvall, Erik Ringberg, David Jansson
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Patent number: 12251681Abstract: The invention discloses method for manufacturing agar or agarose beads, comprising the steps of: a) providing a water phase comprising an aqueous solution of agar or agarose at a temperature of 40-100° C.: b) providing an oil phase comprising a water-immiscible solvent and an emulsifier at a temperature of 40-100° C.; c) emulsifying the water phase in the oil phase to form a water-in-oil emulsion: d) cooling the water-in-oil emulsion to a temperature below a gelation temperature of the agar or agarose to form a dispersion of solidified agar or agarose beads: and e) recovering agar or agarose beads from dispersion, wherein the emulsifier comprises a phosphate ester of an alkoxylated fatty alcohol.Type: GrantFiled: April 28, 2020Date of Patent: March 18, 2025Assignee: Cytiva BioProcess R&D ABInventors: Susanna Lindberg, Jonas Gustafsson, Linn Carlsson, Anders Hagvall, Erik Ringberg, David Jansson
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Publication number: 20220219141Abstract: The invention discloses method for manufacturing agar or agarose beads, comprising the steps of: a) providing a water phase comprising an aqueous solution of agar or agarose at a temperature of 40-100° C.: b) providing an oil phase comprising a water-immiscible solvent and an emulsifier at a temperature of 40-100° C.; c) emulsifying the water phase in the oil phase to form a water-in-oil emulsion: d) cooling the water-in-oil emulsion to a temperature below a gelation temperature of the agar or agarose to form a dispersion of solidified agar or agarose beads: and c) recovering agar or agarose beads from dispersion, wherein the emulsifier comprises a phosphate ester of an alkoxy lated fatty alcohol.Type: ApplicationFiled: April 28, 2020Publication date: July 14, 2022Inventors: Susanna Lindberg, Jonas Gustafsson, Linn Carlsson, Anders Hagvall, Erik Ringberg, David Jansson
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Patent number: 8496123Abstract: The invention relates to a process for making porous cross-linked cellulose membranes and processes for coupling a chromatography ligand to cross-linked cellulose membranes. The invention provides methods for separating a first component from a second component in a solution based upon a difference in the size of the first and second components, and methods for separating target molecules from other components in a solution comprising use of membranes obtainable by the process of the invention. The method has particular utility in separating proteins from cell lysates and cultures.Type: GrantFiled: July 24, 2006Date of Patent: July 30, 2013Assignee: GE Healtcare Bio-Sciences ABInventors: Andreas Axen, Anders Hagvall, Anders Larsson, Nicolas Thevenin
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Patent number: 8309709Abstract: The present invention relates to a method of preparing an insoluble separation matrix, which method comprises salt-treatment of a polysaccharide gel followed by cross-linking of the polysaccharide polymers. In one embodiment, the method comprises providing an aqueous solution of a gelatable native polysaccharide; lowering the temperature of the polysaccharide solution to a value below its gelling point; salt-treatment by adding at least one salt to the resulting polysaccharide; and cross-linking the salt-treated polysaccharide. The polysaccharide may be prepared e.g. into particles, membranes or monoliths.Type: GrantFiled: June 28, 2006Date of Patent: November 13, 2012Assignee: GE Healthcare Bio-Sciences ABInventors: Hans Berg, Maria Brannholm, David Buckley, Philippe Busson, Anders Hagvall, Eva Holmgren, Henrik Ihre, Anders Larsson, Dag Lindstrom
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Publication number: 20080179248Abstract: The invention relates to a process for making porous cross-linked cellulose membranes and processes for coupling a chromatography ligand to cross-linked cellulose membranes. The invention provides methods for separating a first component from a second component in a solution based upon a difference in the size of the first and second components, and methods for separating target molecules from other components in a solution comprising use of membranes obtainable by the process of the invention. The method has particular utility in separating proteins from cell lysates and cultures.Type: ApplicationFiled: July 24, 2006Publication date: July 31, 2008Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Andreas Axen, Anders Hagvall, Anders Larsson, Nicolas Thevenin
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Patent number: 7396467Abstract: The present invention relates to a method of preparing a porous cross-linked polysaccharide chromatography matrix, which comprises to provide an aqueous solution of a gellable polysaccharide, wherein part of the hydroxyl groups are substituted with groups which are not susceptible to nucleophilic attack; to provide essentially spherical droplets of the substituted polysaccharide solution; to form a gel of the substituted polysaccharide solution; and to cross-link the gel by adding a cross-linking agent. The invention also encompasses a chromatography column packed with a matrix so produced as well as use thereof in e.g. protein purification.Type: GrantFiled: October 13, 2004Date of Patent: July 8, 2008Assignee: GE Healthcare Bio-Sciences ABInventors: Hans Berg, David Buckley, Maria Brännholm, Anders Hagvall, Henrik Ihre, Eva Holmgren, Anders Larsson, Dag Lindstrom
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Publication number: 20080154031Abstract: The present invention relates to a method of preparing an insoluble separation matrix, which method comprises salt-treatment of a polysaccharide gel followed by cross-linking of the polysaccharide polymers. In one embodiment, the method comprises providing an aqueous solution of a gelatable native polysaccharide; lowering the temperature of the polysaccharide solution to a value below its gelling point; salt-treatment by adding at least one salt to the resulting polysaccharide; and cross-linking the salt-treated polysaccharide. The polysaccharide may be prepared e.g. into particles, membranes or monoliths.Type: ApplicationFiled: June 28, 2006Publication date: June 26, 2008Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Hans Berg, Maria Brannholm, David Buckley, Philippe Busson, Anders Hagvall, Eva Holmgren, Henrik Ihre, Anders Larsson, Dag Lindstrom
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Publication number: 20060060534Abstract: The present invention relates to a method of preparing a porous cross-linked polysaccharide chromatography matrix, which comprises to provide an aqueous solution of a gellable polysaccharide, wherein part of the hydroxyl groups are substituted with groups which are not susceptible to nucleophilic attack; to provide essentially spherical droplets of the substituted polysaccharide solution; to form a gel of the substituted polysaccharide solution; and to cross-link the gel by adding a cross-linking agent. The invention also encompasses a chromatography column packed with a matrix so produced as well as use thereof in e.g. protein purification.Type: ApplicationFiled: October 13, 2004Publication date: March 23, 2006Inventors: Hans Berg, David Buckley, Maria Brannholm, Anders Hagvall, Henrik Ihre, Eva Holmgren, Anders Larsson, Dag Lindstrom