Abstract: An ingestible device (200), comprising: a housing (210, 220) comprising a stop geometry (228) at an exit hole (224); a tissue penetrating member (230) and an actuator that comprises: a pushing portion (260) configured for axial movement from a first to a second position, the pushing portion configured to move the tissue penetrating member from within the housing to a lodged position in tissue, and a holder portion (270) coupled with the pushing portion (260) for initial axial movement with the pushing portion. In the first position the holder portion releasably holds the tissue penetrating member (230) in axial retaining engagement. As the pushing portion (260) moves towards the second position, the tissue penetrating member (230) moves through the exit hole (224) until the holder portion (270) enters into engagement with the stop geometry (228). The pushing portion (260) moves further to release and advance the tissue penetrating member (230).

Abstract: The present invention concerns an elastomeric stopper (18, 28, 38) for a drug reservoir, comprising: a stopper body (18.1, 28.1, 38.1) extending along a reference axis between a leading end surface (18.2, 28.2, 38.2) and a trailing end surface (18.3, 28.3, 38.3) and having a generally cylindrical sidewall with an outer body diameter, a circumferential convex rib (18.6, 28.6, 38.6) extending radially outwardly from the sidewall, a non-convex trim edge portion (18.7, 28.7, 38.7) at the trailing end surface (18.3, 28.3, 38.3), the non-convex trim edge portion (18.7, 28.7, 38.7) having an outer trim edge diameter which is greater than the outer body diameter and being axially spaced apart from the circumferential convex rib (18.6, 28.6, 38.6), providing an annular recess (18.9, 28.9, 38.9) therebetween. The elastomeric stopper (18, 28, 38) further comprises a channel structure (18.10, 28.10, 38.10) enabling fluid flow from the trailing end surface (18.3, 28.3, 38.3) to the annular recess (18.9, 28.9, 38.