Patents by Inventor Anders Matthew Knight

Anders Matthew Knight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED ADENYLATE KINASE VARIANTS
    Publication number: 20250122488
    Abstract: The present disclosure provides engineered adenylate kinases, and recombinant polynucleotides encoding the engineered adenylate kinases. The present disclosure further provides uses of the engineered adenylate kinases for converting NMP to NDP.
    Type: Application
    Filed: October 11, 2024
    Publication date: April 17, 2025
    Inventors: Stephanie Marie Forget, Anders Matthew Knight, Marissa Greene MacAvoy, Simon Ng, Nicholas Porter, Jonathan Vroom
  • RNA POLYMERASE VARIANTS
    Publication number: 20240376449
    Abstract: The present disclosure relates to engineered RNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered RNA polymerase polypeptides. The present disclosure also provides methods of using the engineered RNA polymerase polypeptides or compositions thereof for producing RNA.
    Type: Application
    Filed: May 10, 2024
    Publication date: November 14, 2024
    Inventors: Marina Mikhailovna Bakhtina, Rachelle Copeland, Aldo Duran, Anders Matthew Knight, Melissa Ann Mayo
  • P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
    Publication number: 20240318152
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity on a 1-tert-Butoxycarbonylaminocyclopentanoic acid substrate.
    Type: Application
    Filed: November 21, 2023
    Publication date: September 26, 2024
    Inventors: David Entwistle, Jason Fell, Stephan Jenne, Anders Matthew Knight, Simon Ng, Ryan D. Reeves, Zara Maxine Seibel, Jonathan Vroom
  • ENGINEERED DNA LIGASE VARIANTS
    Publication number: 20240309353
    Abstract: The present disclosure relates to engineered DNA ligase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA ligase polypeptides. The present disclosure also provides methods of using the engineered DNA ligase polypeptides or compositions thereof in diagnostics and as a molecular biological tool.
    Type: Application
    Filed: January 23, 2024
    Publication date: September 19, 2024
    Inventors: Jacob Hansen Artz, Rachelle Copeland, Jason Fell, Anders Matthew Knight, Mikayla Jianghongxia Krawczyk, Mathew G. Miller, Jovana Nazor, Amani Shoubber, Jonathan Vroom
  • ENGINEERED 3-O-KINASE VARIANTS AND METHODS OF USE
    Publication number: 20240209408
    Abstract: The present invention provides engineered 3?O-kinase polypeptides useful for construction of materials used in template-independent polynucleotide synthesis, as well as compositions and methods of utilizing these engineered polypeptides. The present disclosure also describes one-pot methods for conversion of a natural or modified nucleoside to a nucleoside tetraphosphate or NQP.
    Type: Application
    Filed: October 12, 2023
    Publication date: June 27, 2024
    Applicant: Codexis, Inc.
    Inventors: David Entwistle, Stephanie Marie Forgel, Anders Matthew Knight, Mikayla Krawczyk, Philip Provencher, Amani Shoubber, Jonathan Vroom, David Watts, Leland Wong
  • ENZYMATIC SYNTHESIS OF NTP AND NQP
    Publication number: 20240209406
    Abstract: The present disclosure provides enzymatic methods for the production of 3?-phosphate-nucleoside-5?-triphosphate (NQP). The present disclosure further provides enzymatic methods for the production of nucleotide-5?-triphosphates.
    Type: Application
    Filed: October 12, 2023
    Publication date: June 27, 2024
    Inventors: David Entwistle, Stephanie Marie Forget, Anders Matthew Knight, Mikayla Jianghongxia Krawczyk, Marissa Greene MacAvoy, Simon Ng, Nicholas Porter, Philip Provencher, Amani Shoubber, Leann Quertinmont Teadt, Jonathan Vroom, David Watts, Leland Ken Wong
  • P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
    Publication number: 20240190926
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity on indanone substrates.
    Type: Application
    Filed: November 21, 2023
    Publication date: June 13, 2024
    Inventors: Margie Tabuga Borra-Garske, Jessica Anna Hurtak, Anders Matthew Knight, Kalyanaraman Krishnamoorthy, Jovana Nazor, James Nicholas Riggins, Nandhitha Subramanian, Jonathan Vroom
  • ENGINEERED URIDINE PHOSPHORYLASE VARIANT ENZYMES
    Publication number: 20240132858
    Abstract: The present invention provides engineered uridine phosphorylase (UP) enzymes, polypeptides having UP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing UP enzymes are also provided. The present invention further provides compositions comprising the UP enzymes and methods of using the engineered UP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
    Type: Application
    Filed: January 3, 2024
    Publication date: April 25, 2024
    Inventors: Jonathan Vroom, Jessica Anna Hurtak, Anders Matthew Knight
  • Engineered uridine phosphorylase variant enzymes
    Patent number: 11898174
    Abstract: The present invention provides engineered uridine phosphorylase (UP) enzymes, polypeptides having UP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing UP enzymes are also provided. The present invention further provides compositions comprising the UP enzymes and methods of using the engineered UP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: February 13, 2024
    Assignee: Codexis, Inc.
    Inventors: Jonathan Vroom, Jessica Anna Hurtak, Anders Matthew Knight
  • ENGINEERED TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE VARIANTS
    Publication number: 20230183663
    Abstract: The present invention provides engineered terminal deoxynucleotidyl transferase (TdT) polypeptides useful in template-independent polynucleotide synthesis using a nucleoside triphosphate-3?-O-removable blocking group (NTP-3?-O-RBG), as well as compositions, methods of utilizing these engineered polypeptides, and polynucleotides encoding the engineered terminal deoxynucleotidyl transferases.
    Type: Application
    Filed: October 13, 2022
    Publication date: June 15, 2023
    Inventors: Charlene Ching, Stephanie Marie Forget, Anders Matthew Knight, Mikayla Jianghongxia Krawczyk, Niusha Mahmoodi, Melissa Ann Mayo, Mathew G. Miller, Jonathan Vroom
  • ENGINEERED URIDINE PHOSPHORYLASE VARIANT ENZYMES
    Publication number: 20220195400
    Abstract: The present invention provides engineered uridine phosphorylase (UP) enzymes, polypeptides having UP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing UP enzymes are also provided. The present invention further provides compositions comprising the UP enzymes and methods of using the engineered UP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
    Type: Application
    Filed: December 17, 2021
    Publication date: June 23, 2022
    Inventors: Jonathan Vroom, Jessica Anna Hurtak, Anders Matthew Knight