Abstract: Isolated peptides and pharmaceutical compositions comprising isolated peptides that bind to retinoblastoma binding protein 4 (RBBp4) and block the Spalt-Like Transcription Factor 4 (SALL4)-RBBp4 interaction are described. Methods of inhibiting binding of SALL4 to RBBp4 and methods of treating a subject having a disorder mediated by a dysregulation of SALL4 are also described.

Abstract: A bracket for a transport frame, configured to hold a hub of a wind turbine in place at the transport frame during transport of the hub, the bracket holding the hub during the transport of the hub and mechanically connecting a holding device and the transport frame for attaching the holding device at the transport frame, for moving the holding device relative to the transport frame, and for moving a contacting portion of the holding device against the hub, which is arranged in a predetermined position on the transport frame is provided. A transport frame is also provided that includes, at least one bracket.

Abstract: The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with kinases.

Abstract: The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with kinases.

Abstract: The present invention provides, in certain embodiments, isolated peptides and pharmaceutical compositions comprising isolated peptides that bind to retinoblastoma binding protein 4 RBBp4 such that, the binding blocks the SALL4-RBBp4 interaction. Methods of inhibiting binding of SALL4 with RBBp4 and methods for treating a subject having a disorder mediated by a dysregulation of SALL4 are also provided.

Abstract: Compounds For Inhibition Of Cancer and Epigenesis. The present invention relates to quinolines and 5,6,7,8-tetrahydroacridines of the formula (I) wherein Z1, Z2, X, R1 to R8 and Y are defined as described in the specification, or a pharmaceutically acceptable form or prodrug thereof, that are inhibitors of methyl transferases such as protein lysine methyltransferases and more particularly SMYD3. The present invention also relates to the methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with enzymes having methyl transferase activities/functions and/or via unspecified/multi-targeted mechanisms.

Abstract: The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein R1 represents optionally substituted alkyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkoxy); optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); or -alkylaryl; R2 represents H; or alkyl; R3 represents H; or alkyl; U, V and W represent —(CH2)—; or U and V together represent —CH?CH— and W represents C?O; Y represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); or optionally substituted heterocyclyl (wherein opti

Abstract: A microphone assembly comprising: a microphone for converting an acoustic signal to an electrical microphone signal; a tube enclosing at least a part of a first conductor for conducting the microphone signal, the tube comprising a rigid first tube part and a rigid second tube part. The first tube part has a first primary tube end and a first secondary tube end, wherein the microphone is attached at the first primary tube end. The second tube part has a second primary tube end and a second secondary tube end. A first rotating connector between the first tube part and the second tube part allows rotating the first tube part in relation to the second tube part about a first rotation axis.

Abstract: A microphone system includes a microphone with a microphone output for converting a first acoustic audio signal to a microphone signal, the system including: a head part including a loudspeaker with a loudspeaker input for converting a loudspeaker signal to a second acoustic audio signal; a first connector for connecting the system to an auxiliary device and including a housing and a first terminal; a unit for preprocessing the microphone signal having at least a first input connected to the microphone output, a first output connected to the loudspeaker input, and a second output connected to the first terminal. The unit is configured to: receive the microphone signal on the first input to form a input signal; and process the input signal to form first and second output signals on the first and second outputs, respectively, the first output signal and the second output signal based on the input signal.

Abstract: A microphone system including: an ear hook including a body member, a hook part and an output member; a microphone boom; a microphone connected to a first conductor and mounted on the microphone boom; a loudspeaker connected to a second conductor, wherein the microphone system is configured to feed an acoustic audio signal from the first loudspeaker via the output member; and an electrical connector for connecting the microphone system to an auxiliary device.

Abstract: The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with kinases.

Abstract: The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumors and cancers as well as other disorders or conditions related to or associated with kinases.

Abstract: A microphone assembly is disclosed, the microphone assembly comprising: a microphone for converting an acoustic signal to an electrical microphone signal; and a rigid tube with a first tube end and a second tube end. The microphone is attached at the first tube end. The rigid tube encloses at least a part of a first conductor for conducting the microphone signal. The rigid tube has a first tube part extending along a first axis, and the rigid tube has a first bend between the first tube end and the first tube part. A clamp member is mounted on the rigid tube, wherein the clamp member is configured for clamping the microphone assembly to a piece of clothing placed between a clamping section of the rigid tube and a clamping section of the clamp member.

Abstract: The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein R1 represents optionally substituted alkyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkoxy); optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); or -alkylaryl; R2 represents H; or alkyl; R3 represents H; or alkyl; U, V and W represent —(CH2)—; or U and V together represent —CH?CH— and W represents C?O; Y represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); or optionally substituted heterocyclyl (wherein opti

Abstract: A microphone assembly comprising: a microphone for converting an acoustic signal to an electrical microphone signal; a tube enclosing at least a part of a first conductor for conducting the microphone signal, the tube comprising a rigid first tube part and a rigid second tube part. The first tube part has a first primary tube end and a first secondary tube end, wherein the microphone is attached at the first primary tube end. The second tube part has a second primary tube end and a second secondary tube end. A first rotating connector between the first tube part and the second tube part allows rotating the first tube part in relation to the second tube part about a first rotation axis.

Abstract: A microphone assembly is disclosed, the microphone assembly comprising: a microphone for converting an acoustic signal to an electrical microphone signal; and a rigid tube with a first tube end and a second tube end. The microphone is attached at the first tube end. The rigid tube encloses at least a part of a first conductor for conducting the microphone signal. The rigid tube has a first tube part extending along a first axis, and the rigid tube has a first bend between the first tube end and the first tube part. A clamp member is mounted on the rigid tube, wherein the clamp member is configured for clamping the microphone assembly to a piece of clothing placed between a clamping section of the rigid tube and a clamping section of the clamp member.

Abstract: The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to heteroalkyl linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumors and cancers as well as other conditions or disorders associated with kinases.

Abstract: The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumors and cancers as well as other disorders or conditions related to or associated with kinases.

Abstract: The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with kinases.

Abstract: The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to heteroalkyl linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other conditions or disorders associated with kinases.