Patents by Inventor Andiliy Lai

Andiliy Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DEUBIQUITINASE INHIBITORS
    Publication number: 20170088520
    Abstract: Described herein are compounds that are deubiquitinase inhibitors, methods of making pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from inhibition of deubiquitinase activity.
    Type: Application
    Filed: May 27, 2015
    Publication date: March 30, 2017
    Inventors: Andiliy LAI, John Howard HUTCHINSON, David LONERGAN, Fei HUANG
  • Urea derivatives as FLT-3 modulators
    Publication number: 20050267182
    Abstract: The invention provides methods and compositions for treating conditions mediated FLT-3. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: December 1, 2005
    Inventors: Zdravko Milanov, Shamal Mehta, Robert Grotzfeld, Andiliy Lai, Hitesh Patel, David Lockhart
  • Amide derivatives as kinase modulators
    Publication number: 20050261315
    Abstract: The invention provides methods and compositions for treating conditions mediated by various kinases wherein derivatives of amide compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: November 24, 2005
    Inventors: Shamal Mehta, Robert Grotzfeld, Zdravko Milanov, Andiliy Lai, Hitesh Patel, David Lockhart
  • Urea derivatives as PDGFR modulators
    Publication number: 20050197371
    Abstract: The invention provides methods and compositions for treating conditions mediated by PDGFR. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: September 8, 2005
    Inventors: Zdravko Milanov, Hitesh Patel, Robert Grotzfeld, Shamal Mehta, Andiliy Lai, David Lockhart
  • Urea derivatives as C-kit modulators
    Publication number: 20050192314
    Abstract: The invention provides methods and compositions for treating conditions mediated by c-kit kinase. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: September 1, 2005
    Inventors: Shamal Mehta, Zdravko Milanov, Robert Grotzfeld, Hitesh Patel, Andiliy Lai, David Lockhart
  • Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
    Publication number: 20050187389
    Abstract: Described herein are compounds and compositions for modulating kinase activity, and methods for modulating kinase activity using the compounds and compositions. Also described herein are methods of using the compounds and/or compositions in the treatment and prevention of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: January 13, 2005
    Publication date: August 25, 2005
    Inventors: Zdravko Milanov, Shamal Mehta, Andiliy Lai, Hitesh Patel, Robert Grotzfeld, David Lockhart
  • Amide derivatives as FLT-3 modulators
    Publication number: 20050171171
    Abstract: The invention provides methods and compositions for treating conditions mediated by flt-3 wherein derivatives of amide compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: August 4, 2005
    Inventors: Shamal Mehta, Robert Grotzfeld, Zdravko Milanov, Andiliy Lai, Hitesh Patel, David Lockhart
  • Amide derivatives as PDGFR modulators
    Publication number: 20050171172
    Abstract: The invention provides methods and compositions for treating conditions mediated by PDGFR wherein derivatives of amide compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: August 4, 2005
    Inventors: Andiliy Lai, Shamal Mehta, Zdravko Milanov, Robert Grotzfeld, Hitesh Patel, David Lockhart
  • Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
    Publication number: 20050165029
    Abstract: Described herein are compounds and compositions for modulating kinase activity, and methods for modulating kinase activity using the compounds and compositions. Also described herein are methods of using the compounds and/or compositions in the treatment and prevention of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: January 13, 2005
    Publication date: July 28, 2005
    Inventors: Hitesh Patel, Shamal Mehta, Andiliy Lai, Zdravko Milanov, Robert Grotzfeld, David Lockhart
  • Urea derivatives as kinase modulators
    Publication number: 20050165024
    Abstract: The invention provides methods and compositions for treating conditions mediated by various kinases wherein derivatives of urea compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: July 28, 2005
    Inventors: Zdravko Milanov, Hitesh Patel, Robert Grotzfeld, Shamal Mehta, Andiliy Lai, David Lockhart
  • Urea derivatives as ABL modulators
    Publication number: 20050165031
    Abstract: The invention provides methods and compositions for treating conditions mediated by Bcr-Abl. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: July 28, 2005
    Inventors: Robert Grotzfeld, Hitest Patel, Shamal Mehta, Zdravko Milanov, Andiliy Lai, David Lockhart
  • Amide derivatives as C-KIT modulators
    Publication number: 20050165074
    Abstract: The invention provides methods and compositions for treating conditions mediated by c-kit wherein derivatives of amide compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: July 28, 2005
    Inventors: Robert Grotzfeld, Zdravko Milanov, Shamal Mehta, Andiliy Lai, Hitesh Patel, David Lockhart
  • Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
    Publication number: 20050153989
    Abstract: Described herein are compounds and compositions for modulating kinase activity, and methods for modulating kinase activity using the compounds and compositions. Also described herein are methods of using the compounds and/or compositions in the treatment and prevention of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: January 13, 2005
    Publication date: July 14, 2005
    Inventors: Robert Grotzfeld, Hitesh Patel, Shamal Mehta, Zdravko Milanov, Andiliy Lai, David Lockhart
  • Conjugated small molecules
    Publication number: 20050153371
    Abstract: Provided herein are linker compounds and conjugates that include the linker compounds. In one embodiment, the linker compounds comprise 2 or 3 residues of 6-aminohexanoic acid and optionally 7-10 residues of polyethyleneglycol (PEG). The linker compounds are useful in forming conjugates with one or more components useful in biopharmaceutical or bioanalytical applications. In particular, the biopharmaceutically useful compounds are kinase inhibitors. The conjugates described herein have utility in a variety of diagnostic, separation, and therapeutic applications.
    Type: Application
    Filed: January 7, 2005
    Publication date: July 14, 2005
    Inventors: Robert Grotzfeld, Zdravko Milanov, Hitesh Patel, Andiliy Lai, Shamal Mehta, David Lockhart
  • Amide derivatives as ABL modulators
    Publication number: 20050148605
    Abstract: The invention provides methods and compositions for treating conditions mediated by abl wherein derivatives of amide compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
    Type: Application
    Filed: November 15, 2004
    Publication date: July 7, 2005
    Inventors: Robert Grotzfeld, Hitesh Patel, Shamal Mehta, Zdravko Milanov, Andiliy Lai, David Lockhart