Patents by Inventor Andr as Patthy

Andr as Patthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Plasmids and process for producing recombinant desulphatohirudin HV-1 peptides
    Patent number: 5552299
    Abstract: The present invention relates to a process for producing recombinant desulphatohirudin by means of culturing microorganisms.Concerning the codon usage of microorganisms the synthesized nucleotide sequences were joined downstream of and in reading frame with isolated promoters and signal sequences, subsequently the expression/secretion cassettes comprising the foregoing elements were inserted into plasmid DNAs allowing the cultivation of cells under selective culture conditions. E. coli, Saccharomyces and Streptomyces species were transformed with the said recombinant plasmids to biosynthesize the thrombin inhibitor desulphatohirudin HV-1 which was then isolated and identified.The thus-produced desulphatohirudin can be used to inhibit blood coagulation.
    Type: Grant
    Filed: April 9, 1993
    Date of Patent: September 3, 1996
    Assignee: Biogal Gyogyszergyar Rt.
    Inventors: Istv an Ott, Tibor Klupp, Istv an Moln ar, Andr as Patthy, Istv an Barta, Zsuzsa Bark o n ee T oth, G abor Ambrus, J anos Sal at, Anik o Tegdes, Imre Moravcsik, Cecilia Egy ud, K arnly Albrecht, K alm an K oncz ol, Attila Vincze, Eva Barab as, Gy orgy M at e, Gy orgy B. Kiss, P eter Kiss, K alm an P olya, J anos Erdei, Eva Guly as, Erika Zilahi