Abstract: Improved spherical beads that may be used in producing pharmaceutically active pellets by depositing a pharmaceutically active agent on the surface of said spherical beads. The spherical beads includes a pharmaceutically acceptable carrier material, including: a) at least 60 wt. % of phosphoric acid calcium salt and b) up to 40 wt. % of organic material. Greater than or equal to 90 wt % of the spherical beads have a particle size in the range of from 90 ?m to 1200 ?m. The spherical beads have: a bulk density of at least or more than 1000 g/l, a specific surface area of at most or less than 10 m2/g, and a hardness of at least or more than 600 g/mm2. Also included is a method for producing such spherical beads and to pharmaceutically active pellets being prepared by depositing a pharmaceutically active agent on the surface of the spherical beads.

Abstract: Improved spherical beads that may be used in producing pharmaceutically active pellets by depositing a pharmaceutically active agent on the surface of said spherical beads. The spherical beads includes a pharmaceutically acceptable carrier material, including: a) at least 60 wt. % of phosphoric acid calcium salt and b) up to 40 wt. % of organic material. Greater than or equal to 90 wt % of the spherical beads have a particle size in the range of from 90 ?m to 1200 ?m. The spherical beads have: a bulk density of at least or more than 1000 g/l, a specific surface area of at most or less than 10 m2/g, and a hardness of at least or more than 600 g/mm2. Also included is a method for producing such spherical beads and to pharmaceutically active pellets being prepared by depositing a pharmaceutically active agent on the surface of the spherical beads.

Abstract: A site positioning system for an underground machine includes a first prism coupled with the underground machine, a second prism operatively coupled with the underground machine, a primary total station, and a reference prism may be in communication with the primary total station. A positioning controller is configured to control, responsive to receiving a High Accuracy Machine Position mode, the primary total station to monitor the first prism and the second prism and transmit a first prism position and a second prism position, respectively, to the positioning controller; control, responsive to receiving a Low Accuracy Machine Position mode, the primary total station to monitor the first prism and transmit the first prism position to the positioning controller; determine, responsive to receiving a Reference Prism Measurement mode, whether a reference prism measurement has been completed, and present positioning information for the machine based on one or more of the prism positions.