Abstract: Derivatives of 10S, 17S-diHIDA (protectin DX, PDX) and medicinal uses thereof are disclosed. These derivatives are specialized pro-resolving mediators (SPRMs). In specific embodiments, said derivatives are used in to prevent or treat viral infections (including influenza and coronavirus infections), insulin resistance, diabetes, and inflammatory disorders.

Abstract: A method for the synthesis of specialized pro-resolving mediators, structural isomers thereof and analogs thereof is disclosed herein. The method comprises reacting a compound of the formula (I): wherein R1 is alkyl(C?12), cycloalkyl(C?12), alkenyl(C?12), alkylidene(C?12), alkynyl(C?12), aryl, aralkyl, heteroaryl or heteroaralkyl; and X1, X2 and X3 are each independently hydroxy or OP, wherein P is a hydroxy protecting or hydroxy activating group; with a reducing agent under conditions sufficient to produce a compound of the formula (II): wherein: R1, X1, X2 and X3 are as defined above. Novel protectins, more specifically novel structural isomers and analogs of PD1 and PDX are also disclosed.

Abstract: The present invention relates to a composition comprising branched chain amino acid metabolites for use in reducing hepatic triglycerides and/or improving glucose metabolism in an individual.

Abstract: Methods and uses for enhancing or restoring the antitumor response, such as the antitumor immune mediated by immune checkpoint inhibitors, in cancer patients, are described. These methods are based on the administration of castalagin or analogs thereof, and are particularly useful for the treatment of tumors resistant to immunotherapy such as immune checkpoint inhibitor therapy.

Abstract: Novel peptides and their uses are provided. In particular, the peptides are useful for increasing glucose uptake or decreasing hepatic glucose production. The peptides are also useful for regulating glucose levels and/or treating diabetes in a subject.

Abstract: The invention relates to 4-hydroxyisoleucine, isomers, analogs, lactones, salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. More particularly, the invention relates to the use of those compounds in the prevention and treatment of disorders of fat metabolism and related syndromes. The invention further relates to the use of those compounds in the prevention and treatment of obesity and related syndromes including, but not limited to, the cosmetic treatment of a mammal in order to effect a cosmetically beneficial loss of body weight, and more particularly loss of body fat.