Publication number: 20220168436
Abstract: Drug conjugates of formula [D-(X)b-(AA)w-(L)-]n-Ab wherein: D is a drug moiety having the following formula (I) or a pharmaceutically acceptable salt, ester, solvate, tautomer or stereoisomer thereof, wherein: A is selected from R1, R2 and R3 is H, ORa, OCORa, OCOORa, alkyl, alkenyl, alkynyl, etc; R3? is, CORa, COORa, CONRaRb, etc; each of R4to R10 and R12 is alkyl, alkenyl or alkynyl; R11 is H, CORa, COORa, alkyl, alkenyl or alkynyl, or R11 and R12+N+C atoms to which they are attached may form a heterocyclic group; each of R13 and R14 is H, CORa, COORa, alkyl, alkenyl or alkynyl; each Ra and Rb is H, alkyl, alkenyl, alkynyl, etc.
Type:
Application
Filed:
December 16, 2021
Publication date:
June 2, 2022
Inventors:
Carmen CUEVAS MARCHANTE, Juan Manuel DOMINGUEZ CORREA, Andres FRANCESCH SOLLOSO, Maria GARRANZO GARCIA-IBARROLA, Maria Jose MUNOZ ALONSO, Francisco SANCHEZ MADRID, Juan Manuel ZAPATA HERNANDEZ, Alicia GARCIA ARROYO, Maria Angeles URSA PECHARROMAN
Patent number: 11224663
Abstract: Drug conjugates of formula [D-(X)b-(AA)w-(L)-]n-Ab wherein: D is a drug moiety having the following formula (I) or a pharmaceutically acceptable salt, ester, solvate, tautomer or stereoisomer thereof, wherein: A is selected from (II) and (III) R1, R2 and R3 is H, ORa, OCORa, OCO—ORa, alkyl, alkenyl, alkynyl, etc.; R3? is, CORa, COORa, CONRaRb, etc; each of R4 to R10 and R12 is alkyl, alkenyl or alkynyl; R11 is H, CORa, COORa, alkyl, alkenyl or alkynyl, or R11 and R12+N+C atoms to which they are attached may form a heterocyclic group; each of R13 and R14 is H, CORa, COORa, alkyl, alkenyl or alkynyl; each Ra and Rb is H, alkyl, alkenyl, alkynyl, etc.
Type:
Grant
Filed:
June 2, 2014
Date of Patent:
January 18, 2022
Assignee:
PHARMA MAR, S.A.
Inventors:
Cármen Cuevas Marchante, Juan Manuel Domínguez Correa, Andrés Francesch Solloso, María Garranzo García-Ibarrola, María José Munoz Alonso, Francisco Sánchez Madrid, Juan Manuel Zapata Hernández, Alicia García Arroyo, Maria Ángeles Ursa Pecharromán
Publication number: 20160129128
Abstract: Drug conjugates of formula [D-(X)b-(AA)w-(L)-]n-Ab wherein: D is a drug moiety having the following formula (I) or a pharmaceutically acceptable salt, ester, solvate, tautomer or stereoisomer thereof, wherein: A is selected from (II) and (III) R1, R2 and R3 is H, ORa, OCORa, OCO—ORa, alkyl, alkenyl, alkynyl, etc; R3? is, CORa, COORa, CONRaRb, etc; each of R4 to R10 and R12 is alkyl, alkenyl or alkynyl; R11 is H, CORa, COORa, alkyl, alkenyl or alkynyl, or R11 and R12+N+C atoms to which they are attached may form a heterocyclic group; each of R13 and R14 is H, CORa, COORa, alkyl, alkenyl or alkynyl; each Ra and Rb is H, alkyl, alkenyl, alkynyl, etc.
Type:
Application
Filed:
June 2, 2014
Publication date:
May 12, 2016
Inventors:
Cármen CUEVAS MARCHANTE, Juan Manuel DOMÍNGUEZ CORREA, Andrés FRANCESCH SOLLOSO, María GARRANZO GARCÍA-IBARROLA, María José MUNOZ ALONSO, Francisco SÁNCHEZ MADRID, Juan Manuel ZAPATA HERNÁNDEZ, Alicia GARCÍA ARROYO, Maria Ángeles URSA PECHARROMÁN
