Abstract: A system and method for computer aided design includes constructing, by an engineering software tool for a current project, a design of a circuit or a subsystem of an industrial system comprising a plurality of hardware elements. A project knowledge graph is constructed for the current project representing an ontology for a set of elements and element relationships, wherein the set of elements include the plurality of hardware elements. A feature extraction module extracts features of the project knowledge graph related to the plurality of hardware elements. An AI-based advisor runs integrated with the engineering tool during a current project and queries one or more reference knowledge graphs for common features extracted by the feature extraction module, and responsive to identifying additional information related to hardware constraints, generates and displays recommendations to the user for the design.

Abstract: System and method use an engineering software tool to construct a graphical design of an industrial system for a design project and an artificial intelligence (AI) module integrated with the engineering tool to classify functionality of components for a current design project using a trained machine learning-based model. The AI module receives a knowledge graph for the current project based on data associated with the graphical design. The knowledge graph represents an ontology for a set of elements and element relationships respectively, representative of system components. The AI module identifies a functionality for each knowledge graph node based on the classifier model, clusters knowledge graph nodes according to identified functionality, and generates functionality-based recommendations based on the clusters in response to user queries. Compliance validation of the design data to regulation standards and policy is performed at the component level by an inference engine.

Abstract: Automated skill matching is provided in industrial control. The interfaces (12, 17) and/or the production processes (13, 18) of the controller (16) and machine (11) are matched. The matching of the interfaces (12, 17) links parameters except for optional parameters to check for incompatibility. The matching of the production processes (13, 18) uses a cross-product of the process (13) of the machine (11) with the process (18) of the controller (16) to check for incompatibility. The skill checking guides manual confirmation of compatibility, reducing downtime and reducing engineering or programming time. The machine (11) is more likely to operate correctly with the controller (16) due to the automated skill matching.

Abstract: Over the past several decades, rapid advances in semiconductors, automation, and control systems have resulted in the widespread adoption of advanced automated machines (including robots) in complex industrial environments. These machines are deployed in a very wide range of industrial settings and carry out an immense variety tasks in a limited and predefined manner. A systematic approach coordinates the actions of machines to allow a hierarchy of autonomous systems to make decisions about how to meet manufacturing demands, including delegation to lower-level autonomous systems.

Abstract: Automated skill matching is provided in industrial control. The interfaces (12, 17) and/or the production processes (13, 18) of the controller (16) and machine (11) are matched. The matching of the interfaces (12, 17) links parameters except for optional parameters to check for incompatibility. The matching of the production processes (13, 18) uses a cross-product of the process (13) of the machine (11) with the process (18) of the controller (16) to check for incompatibility. The skill checking guides manual confirmation of compatibility, reducing downtime and reducing engineering or programming time. The machine (11) is more likely to operate correctly with the controller (16) due to the automated skill matching.

Abstract: The invention relates to a pharmaceutical composition comprising a compound selected from the group consisting of desethylamiodarone and pharmaceutically acceptable salts, hydrates and solvates thereof, together with pharmaceutically acceptable excipients, vehicle and/or carrier, as well as the pharmaceutical composition for use in the treatment and prevention of atrial fibrillation with fewer side effects than its parent compound.

Abstract: The present invention relates to novel, antiarrhythmically active phenoxyalkylamine derivatives possessing a double point of attack. More particularly, the present invention relates to new phenoxyalkylamine derivatives of the formula (1) wherein R1 and R2, independently from each other, mean hydrogen, halogen or C1-4 alkyl group; R3, R4 and R5, independently from each other, stand for hydrogen or C1-4 alkyl group; R6 represents hydrogen, C1-4 alkyl or benzyl group; R7 means nitro group or amino group optionally monosubstituted by C1-4 alkyl, benzoyl, C1-4 alkylcarbonyl, C1-4 alkylsulfonyl, C1-4 alkylcarbamoyl or C1-4 alkylthiocarbamoyl group; both n and m are 0 or 1, with the proviso that R2 is different from hydrogen, when R1 is hydrogen, as well as stereoisomers or mixtures of stereoisomers thereof, acid addition salts thereof and hydrates, prodrugs and metabolites of all these compounds.

Abstract: Racemic or optically active new 3(2H)-pyridazinone derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said 3(2H)-pyridazinone derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases.

Abstract: The invention is directed to 1-(2,6-Dimethyl-Phenyl-amino)-2-Dimethyl-amino-Propane and the pharmaceutical composition thereof useful for the treatment of cardiac rhythm disorders.

Abstract: The invention relates to new substituted dihydropyridine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.6 are as defined herein after, the racemic and optically active variants as well as mixtures thereof, furthermore the acid addition salts of these compounds, pharmaceutical compositions containing the same and a process for the preparation thereof.The compounds of the general formula (I) can be advantageously applied for the treatment of pathologically severe hypertensions, their toxicity is low and they possess an advantageous therapeutic index.

Abstract: This invention relates to new 3-(hydroxymethyl)-isoquinoline derivatives of the general formula (I), their acid addition salts, and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, ##STR1## wherein R and R.sup.1 are identical or different and stand for a hydrogen or halogen atom, a nitro or a C.sub.1-4 alkoxy group,R.sup.2 stands for a hydrogen atom or a C.sub.1-4 alkyl group,R.sup.3 and R.sup.4 are identical or different and stand for a hydrogen atom or a C.sub.1-4 alkyl group, or R.sup.3 and R.sup.4 combined denote a methylene group,with the proviso that when R stands for 3-methoxy, R.sup.1 for 4-methoxy, R.sup.3 and R.sup.4 are identical and represent methyl or ethyl groups, R.sup.2 is other than hydrogen atom.

Abstract: The invention relates to novel pyrimido [5,4-b][1,4]oxazine derivatives of the formula (I), and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) ##STR1## wherein R.sup.1 stands for a C.sub.1-4 alkyl group;R.sup.2 stands for hydrogen or halogen or an azido group or an --NR.sup.5 R.sup.6 group, whereinR.sup.5 represents hydrogen or a benzyl group, or a C.sub.1-4 alkyl group unsubstituted or substituted by a hydroxyl group,R.sup.6 stands for hydrogen, an amino group, a C.sub.3-6 cycloalkyl group, a straight or branched-chain C.sub.1-4 alkyl group optionally substituted by a hydroxyl, mercapto, aminocarbonyl, furyl, 2-benzo[1,4]dioxanyl, di(C.sub.1-4 alkyl)amino group or by a phenyl or phenoxy group optionally mono- or polysubstituted by halogen or C.sub.1-4 alkoxy group (s) or by a 6-membered, saturated nitrogen-containing heterocycle optionally containing an additional nitrogen or oxygen atom and optionally substituted by a C.

Abstract: The invention relates to new aminoguanidine derivatives of the general formula (I), ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each represent hydrogen or halogen atom, C.sub.1-4 alkyl, nitro, trifluoromethyl or C.sub.1-4 alkoxy group,R.sup.4 and R.sup.5 represent a C.sub.1-4 alkyl group, furthermore NR.sup.4 R.sup.5 may form a 5 to 7 membered saturated heterocyclic group containing either one or two nitrogen atoms or a nitrogen and an oxygen atom and being optionally substituted by one or two methyl, hydroxymethyl or hydroxyethyl groups,R.sup.6 and R.sup.7 each represent a hydrogen atom, normal or branched C.sub.1-4 alkyl or C.sub.2-4 alkenyl group,and to their pharmaceutically acceptable acid addition salts as well as to a process for the preparation thereof.The new compounds of the invention possess valuable antiarrhythmic activity and are devoid of the undesired circulatory side effects of the known antiarrhythmic compounds.