Abstract: The present invention relates to methods and compositions for the size-adjusted recombinant production of magnetic nanoparticles. More particular, the invention relates to a method, comprising: providing one or more cells being capable of producing magnetic nanoparticles; modifying in the one or more cells the expression of one or more genes involved in the formation of the magnetic nanoparticles; cultivating the modified cells obtained in step (b); and isolating the magnetic nanoparticles from the cultivated cells, wherein the magnetic nanoparticles have a defined size. In preferred embodiments, the method comprises modifying the expression of one or more genes of the mamGFDC operon in magnetotactic bacterial cells. The invention is further directed to host cells bearing said modifications, the recombinant magnetic particles isolated from such cells as well as to the use of such particles for the detection and/or separation of biomolecules or as a contrast agent in magnetic resonance imaging.

Abstract: The present invention relates to methods and compositions for the size-adjusted recombinant production of magnetic nanoparticles. More particular, the invention relates to a method, comprising: providing one or more cells being capable of producing magnetic nanoparticles; modifying in the one or more cells the expression of one or more genes involved in the formation of the magnetic nanoparticles; cultivating the modified cells obtained in step (b); and isolating the magnetic nanoparticles from the cultivated cells, wherein the magnetic nanoparticles have a defined size. In preferred embodiments, the method comprises modifying the expression of one or more genes of the mamGFDC operon in magnetotactic bacterial cells. The invention is further directed to host cells bearing said modifications, the recombinant magnetic particles isolated from such cells as well as to the use of such particles for the detection and/or separation of biomolecules or as a contrast agent in magnetic resonance imaging.