Patents by Inventor André A. Adams

André A. Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10429376
    Abstract: Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: October 1, 2019
    Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventors: Steven A. Soper, Michael C. Murphy, June Feng, Robin L. McCarley, André A. Adams
  • Patent number: 10208289
    Abstract: A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: February 19, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: André A. Adams, Michael Daniele, Frances S. Ligler
  • Patent number: 9926534
    Abstract: A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: March 27, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: André A. Adams, Michael Daniele, Frances S. Ligler
  • Publication number: 20180072996
    Abstract: A synthetic skin tissue is served by at least one synthetic blood vessel and includes a physiologically representative population of cells including fibroblasts and keratinocytes, wherein some keratinocytes are in a differentiated state.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 15, 2018
    Inventors: André A. Adams, Kyle A. DiVito
  • Publication number: 20180064527
    Abstract: Synthetic human blood vessels can be constructed using human brain derived endothelial cells and incorporated into a tissue model that contains astrocytes and other neurons and microglia. Multi-cell type microvessels incorporate cell types such as astrocytes and pericytes in order to construct a highly representative blood-brain barrier in vitro model with a functional lumen containing brain-derived microvascular endothelial cells and a polymer wall containing human astrocytes and/or pericytes.
    Type: Application
    Filed: September 7, 2017
    Publication date: March 8, 2018
    Inventors: André A. Adams, Kyle A. DiVito, Stella H. North, Michael A. Daniele
  • Publication number: 20180056586
    Abstract: A method of direct-write manufacturing (3D printing) includes a simple to manufacture printhead configured to create sheathed flow. The method is operable at room temperature and suitable for use with sensitive materials.
    Type: Application
    Filed: August 25, 2017
    Publication date: March 1, 2018
    Inventors: David R. Mott, André A. Adams, Jonathan D. Yuen, Michael A. Daniele
  • Publication number: 20160130543
    Abstract: A perfusable, microtube-based flow system for microdevice models of human tissues and organs includes a microfluidic chip with a network of microtubes passing through at least one common chamber space suitable to hold cells of an appropriate organ and/or a biocompatible support matrix. The microtube model network can be used to create model tissues and organs for study and research.
    Type: Application
    Filed: November 10, 2015
    Publication date: May 12, 2016
    Inventors: Michael A. Daniele, Steven A. Roberts, Frances S. Ligler, André A. Adams
  • Publication number: 20150328636
    Abstract: A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
    Type: Application
    Filed: July 1, 2015
    Publication date: November 19, 2015
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: André A. Adams, Michael Daniele, Frances S. Ligler
  • Publication number: 20150322408
    Abstract: A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
    Type: Application
    Filed: July 1, 2015
    Publication date: November 12, 2015
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: André A. Adams, Michael Daniele, Frances S. Ligler
  • Patent number: 9157060
    Abstract: A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: October 13, 2015
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Frances S. Ligler, André A. Adams, Michael Daniele
  • Publication number: 20140087466
    Abstract: A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
    Type: Application
    Filed: March 4, 2013
    Publication date: March 27, 2014
    Inventors: Frances S. Ligler, André A. Adams, Michael Daniele, David R. Mott, Peter B. Howell, JR., Stephanie Fertig, Aron Bobrowski
  • Publication number: 20120100521
    Abstract: Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells.
    Type: Application
    Filed: May 13, 2009
    Publication date: April 26, 2012
    Inventors: Steven A. Soper, Michael C. Murphy, June Feng, Robin L. McCarley, André A. Adams