Patents by Inventor Andras Varadi

Andras Varadi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11046692
    Abstract: Described herein are compounds of Formulae (I?)-(II?), compounds of Formulae (I)-(II) and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful for modulating opioid receptor activity. The provided compounds may have both agonistic and antagonistic effect on one or more opioid receptors. Methods of using the compounds for treating or managing pain are also described.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: June 29, 2021
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Gavril Pasternak, Susruta Majumdar, Rashad Karimov, Andras Varadi
  • Publication number: 20210047337
    Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3, C1-C4 alkyl, aryl or heteroaryl; X is N or CR6, wherein R6 is H, OH, or halogen; A is absent or present, and when present is B has the structure: or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 30, 2020
    Publication date: February 18, 2021
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Konstantin Petrukhin, Kirsten Alison Rinderspacher, Shi-Xian Deng, Andras Varadi, Boglarka Racz, Peter Bernstein, Patricia C. Weber, Donald W. Landry, Andrew S. Wasmuth
  • Publication number: 20190216850
    Abstract: The invention is concerned with use of oral inorganic pyrophosphate for preventing and/or reducing tissue calcification, particularly soft tissue calcification, and/or diseases or disorders characterized by low plasma PPi levels, as, e.g.
    Type: Application
    Filed: September 13, 2017
    Publication date: July 18, 2019
    Inventors: András VÁRADI, Dóra DEDINSZKI, Flóra Mária SZERI, Piet BORST, Jan Koenraad VAN DE WETERING
  • Publication number: 20180134708
    Abstract: Described herein are compounds of Formulae (I?)-(II?), compounds of Formulae (I)-(II) and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful for modulating opioid receptor activity. The provided compounds may have both agonistic and antagonistic effect on one or more opioid receptors. Methods of using the compounds for treating or managing pain are also described.
    Type: Application
    Filed: April 29, 2016
    Publication date: May 17, 2018
    Applicant: Memorial Sloan-Kettering Cancer Center
    Inventors: Gavril Pasternak, Susruta Majumdar, Rashad Karimov, Andras Varadi
  • Patent number: 8129197
    Abstract: The invention provides for a novel cholesterol loaded insect cell membrane preparation having an increased cholesterol level as compared to physiological cholesterol levels of insect cell membranes or to control insect cell membrane preparations without cholesterol loading, wherein said cholesterol loaded membrane preparation comprises an ABC transporter protein having an increased substrate transport activity due to increased cholesterol level of the membrane. The invention also relates to reagent kits comprising the preparations of the invention. The invention also relates to methods for manufacturing said preparations and methods for measuring any type of activity of the ABC transporters present in the cholesterol loaded membranes as well as studying or testing compounds and interaction of compounds and ABC transporters, in this assay systems. The invention also provides for a test system useful for testing whether ABC transporter proteins can be activated by cholesterol in an insect cell membrane.
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: March 6, 2012
    Assignee: SOLVO Biotechnológial ZRT.
    Inventors: György Báthori, Dóra Méhn, Pál Ákos, Péter Krajcsi, Lajos Szente, Éva Fenyvesi, Ágnes Telbisz, Balázs Sarkadi, András Váradi, Szilvia Gedey, Hristos Glavinas, Emese Kis, Tünde Nagy, Attila Németh, Éva Molnár
  • Publication number: 20100021927
    Abstract: The invention provides for a novel cholesterol loaded insect cell membrane preparation having an increased cholesterol level as compared to physiological cholesterol levels of insect cell membranes or to control insect cell membrane preparations without cholesterol loading, wherein said cholesterol loaded membrane preparation comprises an ABC transporter protein having an increased substrate transport activity due to increased cholesterol level of the membrane. The invention also relates to reagent kits comprising the preparations of the invention. The invention also relates to methods for manufacturing said preparations and methods for measuring any type of activity of the ABC transporters present in the cholesterol loaded membranes as well as studying or testing compounds and interaction of compounds and ABC transporters, in this assay systems. The invention also provides for a test system useful for testing whether ABC transporter proteins can be activated by cholesterol in an insect cell membrane.
    Type: Application
    Filed: May 14, 2007
    Publication date: January 28, 2010
    Inventors: György Báthori, Dóra Méhn, Pál Ákos, Péter Krajcsi, Lajos Szente, Éva Fenyvesi, Ágnes Telbisz, Balázs Sarkadi, András Váradi, Szilvia Gedey, Hristos Glavinas, Emese Kis, Tünde Nagy, Attila Németh, Éva Molnár
  • Publication number: 20080187935
    Abstract: The invention relates to methods for screening selective modulators of half transporter proteins of the ABCG family, more closely of ABCG1 and ABCG4. In particular the invention relates to methods for determining whether a substance is a selective activator, an inhibitor or a substrate of an ABCG1 or ABCG4 homodimer or of an ABCG1/ABCG4 heterodimer protein, methods for detection of ABCG1 protein in a biological sample, methods for modulating the function of said proteins, and methods for detecting the presence of and/or quantitating ABCG1/ABCG4 heterodimer activity in a biological sample. Moreover, the invention relates to isolated ABCG1/ABCG4 heterodimer proteins and antibodies selective for ABCG1 or ABCG4. The closely related human ABC half-transporters, ABCG1 and ABCG4, have been suggested to play an important role in cellular lipid/sterol regulation. ABCG1 and ABCG4 and mutants thereof have been expressed and studied by the present inventors in whole cells as well as isolated membrane preparations.
    Type: Application
    Filed: July 8, 2005
    Publication date: August 7, 2008
    Inventors: Judit Cserepes, N. Barry Elkind, Zsofia Szentpetery, Balazs Sarkadi, Andras Varadi, Izabella Klein, Laszlo Homolya, Laszlo Seres, Csilla Ozvegy-Laczka
  • Publication number: 20050255084
    Abstract: The invention relates to an isolated nucleic acid comprising a sequence encoding a half transporter protein of the ABCG-family for use in gene therapy, to the use of the isolated nucleic acid for selecting somatic mammalian cells against at least one drug transportable by the transporter protein, to vectors, cells, pharmaceutical compositions and kits comprising the nucleic acid and methods for protecting and selecting cells against a cytotoxic drug transportable by said transporter protein and for gene therapy methods.
    Type: Application
    Filed: October 24, 2002
    Publication date: November 17, 2005
    Applicant: SOLVO BIOTECHNOLOGY
    Inventors: Katalin Nemet, Gyorgy Varady, Judit Cervenak, Olga Ujhelly, Balazs Sarkadi, Andras Varadi, Csilla Ozvegy
  • Publication number: 20030170730
    Abstract: The invention relates to a method for testing L0-specific inhibitors of transporter proteins of the MRP-family and for testing inhibitors specific to the predicted amphipatic helical region of the L0 region, the tested inhibitors L0 peptide, mutants thereof, polynucleotides coding the peptides. Vectors and hosts cells comprising the polynucleotides and reagent kits for testing and developing the inhibitors. The invention is especially useful for combatting multidrug resistance in cancer patients and in the field of related research.
    Type: Application
    Filed: May 2, 2003
    Publication date: September 11, 2003
    Inventors: Eva Bakos, Balazs Sarkadi, Andras Varadi, Gabor Tusnadi, Raymond Evers