Abstract: Methods and systems for designing phage therapy cocktails. A candidate phage selector module may be configured to predict lytic activity of phages using a first trained machine learning algorithm, and select candidate phages based at least in part on predicted lytic activity. A cocktail generator module may be configured to generate a set of phage cocktails using a second trained machine learning algorithm, based at least in part on predicted lytic activity. A feedback panel module may be configured to receive feedback information associated with phage cocktails, and use the feedback information to train the first and/or second trained machine learning algorithms.

Abstract: A method includes detecting, in a written electronic communication, an input sentence satisfying a readability metric threshold, and processing, by a sentence transformer model responsive to the input sentence satisfying the readability metric threshold, the input sentence to output a suggested set of sentences. The method further includes evaluating the first suggested set of sentences along a set of acceptability criteria, and determining, based on the evaluating, that the set of acceptability criteria is satisfied. The method further includes modifying, based on determining that the set of acceptability criteria is satisfied, the written electronic communication with the suggested set of sentences to obtain a modified written electronic communication, and storing the modified written electronic communication.

Abstract: A process is provided for training a neural network that digitally models an audio system. A sound source is utilized to electrically couple a test signal into an input of a reference audio system. The output of the reference audio system is collected into an audio interface coupled to a computer. A neural network is then trained using the test signal and the captured information to derive a set of weight vectors with appropriate values such that the overall output of the neural network converges towards an output representative of the reference audio system, and a signal in the time domain from a musical instrument is processed through the trained neural network with a latency under 20 milliseconds. A graphical user interface then outputs a graphical representation of the trained neural network, where the graphical representation visually displays at least one virtual control for interaction by a user.

Abstract: A neural network is trained to digitally model a reference audio system. Training is carried out by repeatedly performing a set of operations. The set of operations includes predicting by the neural network, a model output based upon an input, where the output approximates an expected output of the reference audio system, and the prediction is carried out in the time domain. The set of operations also includes applying a perceptual loss function to the neural network based upon a determined psychoacoustic property, wherein the perceptual loss function is applied in the frequency domain. Moreover, the set of operations includes adjusting the neural network responsive to the output of the perceptual loss function. A neural model file is output that can be loaded to generate a virtualization of the reference audio system.

Abstract: A system for emulating a physical audio system comprises a user interface (UI) and a digital model of the physical audio system. The UI comprises virtual controls for changing virtual control settings (e.g., a virtual volume control for changing a virtual volume setting, etc.). A change in a virtual control setting produces a change to the output of the digital model. Because the digital model emulates the behavior of the physical audio system, changes to the model output in response to changes in the virtual control settings correspond to changes in the audio output in response to changes in the physical control settings. For example, if the physical audio system is an audio amplifier with control knobs, then the virtual controls will affect the output of the digital model like the control knobs affect the audio output of the audio amplifier.

Abstract: A robotic system is provided, which automatically changes settings on an audio system. The audio system (e.g., an instrument amplifier, effect processor, etc.) typically includes one or more controls that impact the operation of the audio system. Correspondingly, the robotic system includes a device interface coupled to a control sequencer. The device interface adapts to one or more controls of the audio system that are to be changed. In this regard, the device interface includes one or more control couplers. Each control coupler is adapted to a corresponding control of the audio system to be changed. The control sequencer provides a control sequence to the device interface that causes the control coupler(s) to vary the settings on the audio system. In practical applications, a combination of sequence values of the control sequence can represent a sufficiently high number of samples to determine a responsive behavior of the audio system.

Abstract: A gyral-linear actuator for an encoder comprises an actuator housing having a first end, a second end opposite the first end, and a hollow. A control member extends from the first end of the actuator housing. A spring is positioned within the hollow of the actuator housing. Moreover, a coupler has an encoder connector and an extension that couples the control member to the encoder connector. Under this configuration, when the encoder connector is coupled to a rotary shaft of the encoder, rotation of the control member causes corresponding rotation of the encoder connector so as to turn the rotary shaft of the encoder, and depression of the control member causes corresponding depression of the rotary shaft of the encoder operating a switch function of the rotary encoder.

Abstract: Recurrent C. difficile infections are the major cause of death due to C. difficile, which is the causative agent of approximately 20% of antibiotic-associated diarrheas. Conventional treatments for C. difficile infections are not capable of eliminating the rates of recurrence, which occurs in 20-30% of the cases and may be repetitive, the probability of death being greater in each cycle. Until now, the persistence mechanisms of C. difficile for producing recurrence conditions were unknown. In the present invention, we describe the mechanism by which C. difficile spores persist, and a method of treatment with a pharmacological composition based on an antibiotic and nystatin for preventing recurrent C. difficile infections. The route of administration of nystatin is also protected (i.e., oral, intraperitoneal).

Abstract: The present application provides lipid-based compositions comprising bioactives of natural origin. In particular, the compositions disclosed herein comprise antioxidants, such as anthocyanins, polyphenols, such as curcuminoids, mixtures of omega-3 and omega-7 unsaturated fatty acids, phospholipids, liposoluble vitamins and medium chain triglycerides, which provide a non-pharmacological alternative for the treatment and prevention of liver diseases related to non-alcoholic fatty liver disease (NAFLD).

Abstract: A gyral-linear actuator for an encoder comprises an actuator housing having a first end, a second end opposite the first end, and a hollow. A control member extends from the first end of the actuator housing. A spring is positioned within the hollow of the actuator housing. Moreover, a coupler has an encoder connector and an extension that couples the control member to the encoder connector. Under this configuration, when the encoder connector is coupled to a rotary shaft of the encoder, rotation of the control member causes corresponding rotation of the encoder connector so as to turn the rotary shaft of the encoder, and depression of the control member causes corresponding depression of the rotary shaft of the encoder operating a switch function of the rotary encoder.

Abstract: The present invention relates to the field of nutritional products used as non-pharmacological therapy alternatives for the prevention and/or treatment of metabolic disorders. The lipid-based composition with micronutrients described herein comprises at least 98 weight percent of lipids of natural origin, which include at least one phytosterol and one or more unsaturated fatty acids, and in addition, at least one natural antioxidant, one or more polyphenols of plant origin and at least one chromium compound, this composition achieves positive effects in different metabolic parameters in subjects with metabolic alterations and/or cardiovascular risk.

Abstract: According to various implementations, a dental cleaning device includes a steam conduit and a cooling fluid conduit. The steam conduit has a distal tip with an opening defined therein that allows steam to be applied intraorally close to a dental implant to flush away bacteria that has colonized on or adjacent the dental implant. The cooling fluid conduit has a distal tip with an opening defined therein that allows a cooling fluid to be applied intraorally close to the dental implant following the application of the steam to cool the tissue and prevent overheating of the tissue and bone adjacent the dental implant. For example, the cooling fluid may be applied intermittently with the steam, or the cooling fluid may be applied continuously while the steam is applied intermittently, according to various implementations.

Abstract: A gyral-linear actuator for an encoder comprises an actuator housing having a first end, a second end opposite the first end, and a hollow. A control member extends from the first end of the actuator housing. A spring is positioned within the hollow of the actuator housing. Moreover, a coupler has an encoder connector and an extension that couples the control member to the encoder connector. Under this configuration, when the encoder connector is coupled to a rotary shaft of the encoder, rotation of the control member causes corresponding rotation of the encoder connector so as to turn the rotary shaft of the encoder, and depression of the control member causes corresponding depression of the rotary shaft of the encoder operating a switch function of the rotary encoder.

Abstract: A neural network is trained to digitally model a reference audio system. Training is carried out by repeatedly performing a set of operations. The set of operations includes predicting by the neural network, a model output based upon an input, where the output approximates an expected output of the reference audio system, and the prediction is carried out in the time domain. The set of operations also includes applying a perceptual loss function to the neural network based upon a determined psychoacoustic property, wherein the perceptual loss function is applied in the frequency domain. Moreover, the set of operations includes adjusting the neural network responsive to the output of the perceptual loss function. A neural model file is output that can be loaded to generate a virtualization of the reference audio system.

Abstract: According to various implementations, a dental cleaning device includes a steam conduit and a cooling fluid conduit. The steam conduit has a distal tip with an opening defined therein that allows steam to be applied intraorally close to a dental implant to flush away bacteria that has colonized on or adjacent the dental implant. The cooling fluid conduit has a distal tip with an opening defined therein that allows a cooling fluid to be applied intraorally close to the dental implant following the application of the steam to cool the tissue and prevent overheating of the tissue and bone adjacent the dental implant. For example, the cooling fluid may be applied intermittently with the steam, or the cooling fluid may be applied continuously while the steam is applied intermittently, according to various implementations.

Abstract: According to various implementations, a dental cleaning device includes a steam conduit and a cooling fluid conduit. The steam conduit has a distal tip with an opening defined therein that allows steam to be applied intraorally close to a dental implant to flush away bacteria that has colonized on or adjacent the dental implant. The cooling fluid conduit has a distal tip with an opening defined therein that allows a cooling fluid to be applied intraorally close to the dental implant following the application of the steam to cool the tissue and prevent overheating of the tissue and bone adjacent the dental implant. For example, the cooling fluid may be applied intermittently with the steam, or the cooling fluid may be applied continuously while the steam is applied intermittently, according to various implementations.

Abstract: An electric stovetop includes a vitroceramic top part, an electric heating element built-in below the top part, and a bottom box with the electric heating element mounted through the bottom box. The electrical heating element can include parallel and equidistant tracks defining a rectangular heating area. Each track is divided into three segments, a large central part and two smaller end parts. Each track is positioned corresponding to a sliding button for controlling power to start heating and to control intensity of heat. The sliding button sets each track according to at least three stages of activation: no power, power to the central part, and power to the smaller ends. There can be an intermediate position defined by a midpoint with a tactile stop to indicate the transition from the second stage to the third stage.

Abstract: According to various implementations, a dental cleaning device includes a steam conduit and a cooling fluid conduit. The steam conduit has a distal tip with an opening defined therein that allows steam to be applied intraorally close to a dental implant to flush away bacteria that has colonized on or adjacent the dental implant. The cooling fluid conduit has a distal tip with an opening defined therein that allows a cooling fluid to be applied intraorally close to the dental implant following the application of the steam to cool the tissue and prevent overheating of the tissue and bone adjacent the dental implant. For example, the cooling fluid may be applied intermittently with the steam, or the cooling fluid may be applied continuously while the steam is applied intermittently, according to various implementations.

Abstract: The invention relates to a panel-based solar receiver for a thermal solar tower power plant (4), which comprises: a front panel (8), the external surface of which receives solar radiation (2) from the field of heliostats (3), a back panel (9), sealing elements (10) between the panels (8, 9), arranged at the lateral ends of both, an intake collector (5), located in the upper part of the panels (8, 9), where the heat transfer fluid enters the receiver (1) and an evacuation collector (6), located in the lower part of the panels (8, 9), where the heat transfer fluid leaves the receiver (1); wherein the front panel (8), back panel (9) and the two sealing elements (10) form the receiver body (16), which constitutes a passage for the heat transfer fluid (7) to travel through. Each solar tower can contain one or several panel-based receivers (1) and be arranged in series or in parallel, with the same or a different fluid (7) circulating there through.

Abstract: A system including a power amplifier and a pre-distortion module coupled to the power amplifier. The pre-distortion module includes one or more smaller versions of the power amplifier to generate a pre-distortion signal that compensates for any memory-effect or inertia present in the power amplifier with application on frequency hopping and larger (up to 1 octave) instantaneous bandwidth communication systems.