Patents by Inventor Andre A. Teixeira

Andre A. Teixeira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250179471
    Abstract: Described here are VHH antibody libraries with heavy chain variable domains framework scaffolds having complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members.
    Type: Application
    Filed: February 17, 2023
    Publication date: June 5, 2025
    Inventors: Andrew Raymon Morton Bradbury, Andre A. Teixeira
  • Publication number: 20250020659
    Abstract: Described here are VHH antibody libraries with heavy chain variable domains framework scaffolds having complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members.
    Type: Application
    Filed: August 16, 2024
    Publication date: January 16, 2025
    Inventors: Andrew Raymon Morton Bradbury, Andre A. Teixeira
  • Publication number: 20240384438
    Abstract: Provided herein is an improved method of antibody affinity maturation that uses true natural CDRs from a population of naturally occurring antibodies targeting a single antigen or antigenic epitope such that the improved method produces functional antibodies having low-picomolar affinity antibodies. Also provided herein is an antibody library where the CDRs within a single antibody member of the library are a combination of CDR sequences of naturally occurring antibodies and one or more CDRs are derived from different naturally occurring antibodies targeting a single antigen or antigenic epitope.
    Type: Application
    Filed: July 7, 2022
    Publication date: November 21, 2024
    Applicant: Rules-Based Medicine Inc.
    Inventors: Andrew Raymon Morton Bradbury, Sara D’Angelo, Andre A. Teixeira
  • Publication number: 20240093179
    Abstract: Described here are VHH antibody libraries with heavy chain variable domains framework scaffolds having complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members.
    Type: Application
    Filed: February 17, 2023
    Publication date: March 21, 2024
    Inventors: Andrew Raymon Morton Bradbury, Andre A. Teixeira
  • Publication number: 20230167165
    Abstract: Provided herein is an improved method of antibody affinity maturation that uses true natural CDRs from a population of naturally occurring antibodies targeting a single antigen or antigenic epitope such that the improved method produces functional antibodies having low-picomolar affinity antibodies. Also provided herein is an antibody library where the CDRs within a single antibody member of the library are a combination of CDR sequences of naturally occurring antibodies and one or more CDRs are derived from different naturally occurring antibodies targeting a single antigen or antigenic epitope.
    Type: Application
    Filed: July 7, 2022
    Publication date: June 1, 2023
    Inventors: Andrew Raymon Morton Bradbury, Sara D'Angelo, Andre A. Teixeira