Patents by Inventor Andre Abad

Andre Abad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060288448
    Abstract: Compositions and methods for protecting a plant from an insect pest are provided. Nucleic acid molecules encoding insect protoxins or insect toxins modified to comprise at least one proteolytic activation site that is sensitive to an insect gut protease are provided. Cleavage of a modified insect protoxin at the proteolytic activation site by an insect gut protease produces an active insect toxin in the gut of the insect pest. Cleavage of a modified insect toxin of the invention at a proteolytic activation site results in the production of an active insect toxin in the insect gut that displays improved pesticidal activity relative to the insect toxin that lacks the proteolytic activation site. Methods of using the modified insect protoxin and modified insect toxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided.
    Type: Application
    Filed: June 7, 2006
    Publication date: December 21, 2006
    Applicants: Pioneer Hi-Bred International, Inc., E.I du PONT de NEMOURS and COMPANY
    Inventors: Andre Abad, Gary Chun, Ronald Flannagan, Rafael Herrmann, Albert Lu, Janet Rice, Eric Schepers
  • Publication number: 20060241043
    Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Application
    Filed: June 21, 2006
    Publication date: October 26, 2006
    Applicants: E.I.du PONT de NEMOURS and COMPANY
    Inventors: Ronald Flannagan, Andre Abad
  • Publication number: 20060241044
    Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Application
    Filed: June 21, 2006
    Publication date: October 26, 2006
    Applicants: E.I. du PONT de NEMOURS and COMPANY
    Inventors: Ronald Flannagan, Andre Abad
  • Publication number: 20060242733
    Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Application
    Filed: June 21, 2006
    Publication date: October 26, 2006
    Applicants: E.I. du PONT de NEMOURS and COMPANY
    Inventors: Ronald Flannagan, Andre Abad
  • Publication number: 20060236424
    Abstract: The present invention relates to methods of designing nucleic acid molecules for improved expression of the encoded polypeptides in plants. In such methods, codon usage frequencies are biased towards codon usage frequencies of a plant virus, group of plant viruses, or a subset of nucleic acid molecules therefrom. In preferred embodiments, the encoded polypeptide affects the phenotype of the plant. The invention also pertains to nucleic acid molecules encoding insecticidal polypeptides wherein the nucleic acid molecules have been designed to have plant virus codon-biased. The invention also pertains to transgenic plants and progeny thereof with increased expression of insecticidal polypeptides for improved resistance to insects and other pests that are detrimental to plants of agricultural value.
    Type: Application
    Filed: April 5, 2006
    Publication date: October 19, 2006
    Inventors: Andre Abad, Ronald Flannagan, Rafael Herrmann, Albert Lu, Billy McCutchen, Carl Simmons
  • Publication number: 20060212964
    Abstract: Methods for creating and enhancing insect resistance in plants are provided. The methods comprise stably introducing into a plant a combination of polynucleotides comprising a sequence encoding a lipase polypeptide having insecticidal activity and a sequence encoding a Bt insecticidal protein, where each of these coding sequences is operably linked to a promoter that drives expression in a plant cell. Plants with enhanced insect resistance and seed thereof are also provided. The methods of the invention may be used in a variety of agricultural systems for controlling insect pests, including propagating lineages of insect-resistant crops and targeting coexpression of insecticidal lipase and Bt insecticidal protein to plant organs that are particularly susceptible to infestation.
    Type: Application
    Filed: February 18, 2005
    Publication date: September 21, 2006
    Applicants: Pioneer Hi-Bred International, Inc., E.I. duPont de Nemours and Company
    Inventors: Billy McCutchen, Andre Abad
  • Patent number: 7105332
    Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests. The invention further provides mutagenized nucleic acids that have been modified to encode pesticidal polypeptides such as endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins that may be optimized as well as pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: September 12, 2006
    Assignee: E.I. Du Pont de Nemours and Company
    Inventors: André Abad, Ronald D. Flannagan, Rafael Herrmann, Theodore W. Kahn, Albert L. Lu, Billy F. McCutchen, James K. Presnail, James F. H. Wong, Cao-Guo Yu
  • Publication number: 20060021096
    Abstract: Compositions and methods for protecting a plant from an insect pest are provided. The invention provides mutagenized nucleic acids that have been engineered to encode pesticidal polypeptides having increased resistance to proteolytic degradation by a plant protease. In particular, nucleic acid sequences encoding pesticidal polypeptides modified to comprise a proteolytic protection site that confers resistance to degradation or proteolytic inactivation by a plant protease are provided. Particular embodiments of the invention provide pesticidal polypeptide compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds. These compositions find use in methods for controlling pests, especially plant pests. Novel plant proteases, sequences encoding these proteases, and methods for their use are also provided.
    Type: Application
    Filed: September 12, 2005
    Publication date: January 26, 2006
    Applicants: Pioneer Hi-Bred International, Inc., E.I. du PONT de NEMOURS and COMPANY
    Inventors: Andre Abad, Hua Dong, Rafael Herrmann, Albert Lu, Billy McCutchen, Janet Rice, Eric Schepers, James Wong
  • Publication number: 20050261188
    Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests. The invention further provides mutagenized nucleic acids that have been modified to encode pesticidal polypeptides such as endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins that may be optimized as well as pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Application
    Filed: April 18, 2005
    Publication date: November 24, 2005
    Applicant: E.I. du PONT de NEMOURS and COMPANY
    Inventors: Andre Abad, Ronald Flannagan, Rafael Herrmann, Theodore Kahn, Albert Lu, Billy McCutchen, James Presnail, James Wong, Cao-Guo Yu
  • Publication number: 20050261483
    Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests. The invention further provides mutagenized nucleic acids that have been modified to encode pesticidal polypeptides such as endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins that may be optimized as well as pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Application
    Filed: February 15, 2005
    Publication date: November 24, 2005
    Applicant: E.I. duPont de Nemours and Company
    Inventors: Andre Abad, Ronald Flannagan, Rafael Herrmann, Theodore Kahn, Albert Lu, Billy McCutchen, James Presnail, James Wong, Cao-Guo Yu
  • Publication number: 20050198706
    Abstract: Methods of creating and enhancing insect resistance in plants by introducing non-plant lipases into plants are provided. Plants with enhanced insect resistance and seed from plants thereof are provided. DNA sequences encoding insecticidal lipases and insecticidal lipase gene products that are useful in the practice of this invention are also provided. The compositions and methods of the invention may be used in a variety of agricultural systems for controlling pests, including propagating lineages of insect-resistant crops and targeting expression of these insecticidal lipases to plant organs that are particularly susceptible to infestation, such as roots and leaves.
    Type: Application
    Filed: February 18, 2005
    Publication date: September 8, 2005
    Applicants: Pioneer Hi-Bred International, Inc., E.I duPont deNemours and Company
    Inventors: Billy McCutchen, Andre Abad, James Wong, Cao Yu
  • Publication number: 20050188439
    Abstract: Methods for creating and enhancing insect resistance in plants are provided. The methods comprise stably introducing into a plant a combination of polynucleotides comprising a sequence encoding a lipase polypeptide having insecticidal activity and a sequence encoding a Bt insecticidal protein, where each of these coding sequences is operably linked to a promoter that drives expression in a plant cell. Plants with enhanced insect resistance and seed thereof are also provided. The methods of the invention may be used in a variety of agricultural systems for controlling insect pests, including propagating lineages of insect-resistant crops and targeting coexpression of insecticidal lipase and Bt insecticidal protein to plant organs that are particularly susceptible to infestation.
    Type: Application
    Filed: February 18, 2005
    Publication date: August 25, 2005
    Applicants: Pioneer Hi-Bred International, Inc., E.I. duPont de Nemours and Company
    Inventors: Billy McCutchen, Andre Abad
  • Publication number: 20050166284
    Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.
    Type: Application
    Filed: December 22, 2004
    Publication date: July 28, 2005
    Applicants: Pioneer Hi-Bred International, Inc., E.I. du PONT de NEMOURS and COMPANY
    Inventors: Andre Abad, Ronald Flannagan, Rafael Herrmann, Albert Lu, Billy McCutchen, James Presnail, Janet Rice, James Wong, Cao-Guo Yu
  • Publication number: 20050138685
    Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Application
    Filed: December 21, 2004
    Publication date: June 23, 2005
    Applicant: E.I du Pont de Nemours and Company
    Inventors: Ronald Flannagan, Andre Abad
  • Publication number: 20040210963
    Abstract: Compositions and methods for protecting a plant from an insect pest are provided. The invention provides mutagenized nucleic acids that have been engineered to encode pesticidal polypeptides having increased resistance to proteolytic degradation by a plant protease. In particular, nucleic acid sequences encoding pesticidal polypeptides modified to comprise a proteolytic protection site that confers resistance to degradation or proteolytic inactivation by a plant protease are provided. Particular embodiments of the invention provide pesticidal polypeptide compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds. These compositions find use in methods for controlling pests, especially plant pests. Novel plant proteases, sequences encoding these proteases, and methods for their use are also provided.
    Type: Application
    Filed: December 24, 2003
    Publication date: October 21, 2004
    Applicants: Pioneer Hi-Bred International, Inc., E.I. du PONT de NEMOURS and COMPANY
    Inventors: Andre Abad, Hua Dong, Rafael Herrmann, Albert Lu, Billy F. McCutchen, Janet A. Rice, Eric J. Schepers, James F. Wong