Abstract: The invention provides methods for treating or preventing developmental disorders associated with mutations in the OCD1 gene.

Abstract: The invention provides methods for treating or preventing developmental disorders associated with mutations in the OCD1 gene.

Abstract: The invention provides methods for treating or preventing developmental disorders associated with mutations in the OCD1 gene.

Abstract: The invention provides methods for treating or preventing developmental disorders associated with mutations in the OCD1 gene.

Abstract: The disclosure provides for compounds having immunoproteasome inhibitory activity, and pharmaceutical compositions made thereof. The disclosure further provides for the use of the compounds and compositions in treating various diseases and disorders in a subject that are associated with immunoproteasome activity, including inflammatory disorders, autoimmune disorders, hematological disorders, and neurodegenerative disorders.

Abstract: The disclosure provides for compounds having immunoproteasome inhibitory activity, and pharmaceutical compositions made thereof. The disclosure further provides for the use of the compounds and compositions in treating various diseases and disorders in a subject that are associated with immunoproteasome activity, including inflammatory disorders, autoimmune disorders, hematological disorders, and neurodegenerative disorders.

Abstract: The present invention concerns a surgical ring, configured to be implanted around a biological organ having a pouch or a duct shape. A surgical ring according to the present invention forms a closed loop around the organ, altering its diameter. Variations in ring diameter are reversibly controlled by a system that, in one embodiment, includes a flexible filiform element slidably disposed within the body of the ring and coupled to a first extremity of the ring and also to an actuator disposed near a second extremity of the ring.

Abstract: A surgical ring, designed to be implanted around biological organs comprising a pouch or a duct, so as, on the one hand, to form a closed loop between these two extremities (1, 2), thus forming a first (1) and a second (2) extremity and, on the other hand, to reduce the diameter of the opening of the organ when it is tightened by the ring, the ring including a system for reversibly controlling the variation in its diameter. The system also includes a flexible filiform element (4), inserted longitudinally with possibility of sliding into the material constituting the body of the ring between the first (1) and second (2) extremities, so as to define a fixed portion (5) connected to the first extremity (1) and a free portion (7) associated with an actuator (8) mounted on the ring near the second extremity (2).

Abstract: A surgical ring (1) designed to be implanted around (a) biological organ(s), the ring (1) being formed by a flexible band (2) including a first and second extremity (3, 4), the flexible band (2) being designed to be closed near its two extremities (3, 4) by a closure system so as to form a closed loop featuring an internal contact surface (2A) external 10 surface (2B). The closure system includes a means of encircling (5) that is integral with the first extremity (3) and arranged to evolve between a de-latching configuration, where the means of encircling (5) forms an open collar freeing the second extremity (4), and a latching configuration where the means of encircling (5) forms a closed collar designed to surround the second extremity (4) so as to unite it with the first extremity (3), the closed collar having opposite front (6) and rear (7) faces, between which an encircling opening extends that is designed to accept the second extremity (4).

Abstract: A bioconversion reactor for the anaerobic fermentation of organic material. The bioconversion reactor comprises a shell enclosing a predetermined volume, an inlet port through which a liquid stream containing organic materials enters the shell, and an outlet port through which the stream exits the shell. A series of vertical and spaced-apart baffles are positioned within the shell to force the stream to flow under and over them as it passes from the inlet to the outlet port. The baffles present a barrier to the microorganisms within the shell causing them to rise and fall within the reactor but to move horizontally at a very slow rate. Treatment detention times of one day or less are possible.