Abstract: The present description relates to a conjugated anti-interleukin-5 receptor ?-subunit (IL-5R?) compound comprising cholic acid (ChAc) or a variant thereof, the ChAc conjugated to a non-cell penetrating peptide comprising a nuclear localization sequence (NLS) conjugated to an anti-interleukin-5 receptor ?-subunit (IL-5R?) compound and further conjugated to chemotherapeutic agent and/or a radionuclide.

Abstract: The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (GRLN, growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and/or variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as antagonists or inverse agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, obesity and obesity-associated disorders, appetite or eating disorders, addictive disorders, cardiovascular disorders, gastrointestinal disorders, genetic disorders, hyperproliferative disorders, central nervous system disorders and inflammatory disorders.

Abstract: The wheels at opposite ends of an axle - and which may be twin or tandem wheels -- each have a pressure switch and a tank circuit associated therewith, rotating with the wheel. The tank circuits includes a normally closed pressure-sensitive switch which, when the pressure in the respective tire drops below a certain value, opens the tank circuit. The coil of the tank circuit is coupled with a transducer coil connected to a blocking oscillator which, upon passage of the tank circuit, provides an output pulse. The frequency or recurrence rate of the output pulses from opposite ends of the wheels at an axle are compared in an integrating comparator and, if the frequencies differ after a predetermined integration time, provide an alarm signal. The integrator or a digital counter which should have a number of count stages, only the last one providing an alarm signal to allow for variation in frequency with normal tire pressure when the vehicle rounds a curve.