Patents by Inventor Andre Bourque

Andre Bourque has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for analyzing oligonucleotide analogs
    Patent number: 5627277
    Abstract: Disclosed is a substrate useful for separating unmodified and modified mononucleotides and oligonucleotides. The substrate includes at least 12% (weight:volume) polymer in at least 5M urea and at least 32% (volume:volume) organic solvent, the organic solvent being a chemically stable liquid at room temperature and having a dielectric constant of at least 20. Also provided is a method of separating unmodified and modified mononucleotides and/or oligonucleotides utilizing this substrate.
    Type: Grant
    Filed: January 7, 1994
    Date of Patent: May 6, 1997
    Assignee: Hybridon, Inc.
    Inventors: Aharon S. Cohen, Andre Bourque, Maria Vilenchik
  • Method for detecting charged oligonucleotides in biological fluids
    Patent number: 5506103
    Abstract: Disclosed is a method for detecting and quantitating oligonucleotides with charged internucleotide linkages in biological fluids. In this method, a biological fluid sample is contacted with an anion exchange resin at from 40.degree. C. to 65.degree. C. for a time sufficient to enable oligonucleotides in the sample to adsorb to the resin. The absorbed oligonucleotides are then desorbed with a buffer having a salt concentration of about 1 M to 2.5 M and a pH in the range of about 6.5 to 7.5, the desorption being performed at about 40.degree.-65.degree. C. The oligonucleotides so released are then detected and quantitated.
    Type: Grant
    Filed: November 16, 1993
    Date of Patent: April 9, 1996
    Assignee: Hybridon, Inc.
    Inventors: Aharon S. Cohen, Andre Bourque